Pathophysiology, 6th Edition
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Pathophysiology, 6th Edition


The most trusted and comprehensive textbook on the subject, Pathophysiology is well-known for its authoritative coverage, complete treatment of pediatric pathophysiology, and it offers an enhanced art program.

Pathophysiology 6th Edition takes teaching and learning to a whole new level with an accessible, engaging presentation that makes it easier than ever for students to master this difficult subject. It offers an enhanced program and a wealth of video, audio, and interactive multimedia resources that simplify complex concepts and stimulate learning!

  • Unparalleled coverage of disease processes makes this text the most comprehensive pathophysiology text available.

  • The largest full-color art program in the field illustrates the clinical manifestations of diseases and disease processes

  • Consistent presentations of each disease with pathophysiology, clinical manifestations, and evaluation and treatment help you find the information you need quickly and easily.

  • Ten separate pediatric chapters cover the pathophysiologic effects on children.

  • Aging content is highlighted throughout the text.

  • An Introduction to Pathophysiology section at the beginning of the text provides a solid start to the basics of the study of disease.

  • Algorithms and flowcharts of diseases and disorders illustrate the disease process in an easy-to-understand format.

  • Nutrition and Disease boxes present evidence-based information on the relationship between health promotion through diet and disease.
  • Updated content on leukocytes in pain modulation, seizure disorders, brain injuries and disorders, acute encephalopathies, reproductive disorders, and much more keep you at the cutting edge of this constantly changing field.

  • What’s New? boxes highlight the most current research and findings to ensure you have the most up-to-date information.

  • New animations, review questions, Key Points, and an audio glossary have been added to the Evolve companion website to strengthen your understanding of key concepts.

  • Media Resources Lists encourage you to develop a study plan to master the important content in each chapter.

Introduction to Pathophysiology


Unit I: The Cell

    • Cellular Biology

    • Altered Cellular and Tissue Biology

    • The Cellular Environment: Fluids and Electrolytes, Acids and Bases

    Unit II: Genes and Gene-Environment Interaction

    • Genes and Genetic Diseases

    • Genes, Environment, Life-style, and Common Diseases

    Unit III: Mechanisms of Self-Defense

    • Innate Immunity: Inflammation

    • Adaptive Immunity

    • Alterations in Immunity and Inflammation

    • Infection

    • Stress and Disease

    Unit IV: Cellular Proliferation: Cancer

    • Biology, Clinical Manifestations, and Treatment of Cancer

    • Cancer Epidemiology

    • Cancer in Children


    Unit V: The Neurologic System

    • Structure and Function of the Neurologic System

    • Pain, Temperature Regulation, Sleep, and Sensory Function

    • Alterations in Cognitive Systems, Cerebral Hemodynamics and Motor Function

    • Disorders of the Central and Peripheral Nervous Systems and the Neuromuscular Junction

    • Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders

    • Alterations of Neurologic Function in Children

    Unit VI: The Endocrine System

    • Mechanisms of Hormonal Regulation

    • Alterations of Hormonal Regulation

    Unit VII: The Reproductive Systems

    • Structure and Function of the Reproductive Systems

    • Alterations of the Reproductive Systems

    • Sexually Transmitted Infections

    Unit VIII: The Hematologic System

    • Structure and Function of the Hematologic System

    • Alterations of Erythrocyte Function

    • Alterations of Leukocyte, Lymphoid, and Hemostatic Function

    • Alterations of Hematologic Function in Children

    Unit IX: The Cardiovascular and Lymphatic Systems

    • Structure and Function of the Cardiovascular and Lymphatic Systems

    • Alterations of Cardiovascular Function

    • Alterations of Cardiovascular Function in Children

    Unit X: The Pulmonary System

    • Structure and Function of the Pulmonary System

    • Alterations of Pulmonary Function

    • Alterations of Pulmonary Function in Children

    Unit XI: The Renal and Urologic System

    • Structure and Function of the Renal and Urologic Systems

    • Alterations of Renal and Urinary Tract Function

    • Alterations of Renal and Urinary Tract Function in Children

    Unit XII: The Digestive System

    • Structure and Function of the Digestive System

    • Alterations of Digestive Function

    • Alterations of Digestive Function in Children

    Unit XIII: The Musculoskeletal System

    • Structure and Function of the Musculoskeletal System

    • Alterations of Musculoskeletal Function

    • Alterations of Musculoskeletal Function in Children

    Unit XIV: The Integumentary System

    • Structure, Function, and Disorders of the In
    Kathryn L. McCance, RN, PhD, Professor, College of Nursing, University of Utah, Salt Lake City, UT and Sue E. Huether, RN, PhD, Professor Emeritus, College of Nursing, University of Utah, Salt Lake City, UT


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