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Renal Physiology Elsevier eBook on VitalSource, 5th Edition
Elsevier eBook on VitalSource®

Renal Physiology Elsevier eBook on VitalSource, 5th Edition

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Renal Physiology helps you to quickly and easily grasp the fundamentals of renal physiology and learn how to apply them in a clinical context. Thoroughly updated, this medical textbook in the Mosby Physiology Monograph Series provides a basic understanding of normal kidney function at the cellular and molecular level. Attractively illustrated with clear 2-color diagrams, it also facilitates study with learning objectives, "In the Clinic" and "At the Molecular Level" boxes, chapter summaries, and clinical cases with review questions and explained answers. Online access at www.StudentConsult.com makes this an even more accessible powerful learning resource.

    • Stay current with clear, accurate coverage of the physiology of normal renal function focusing on the needs of the student. 
    • Bridge the gap between normal function and disease with pathophysiology content throughout the book. 
    • Understand complex concepts by examining more than more than 250 clear, 2-color diagrams.
    • Consult the book and image library online at Student Consult, anywhere you go ... perform quick searches ... add your own notes and bookmarks ... and more!
      • Put theory into practice with "In the Clinic" or "At the Molecular Level " boxes in each chapter that explain the practical applications of fundamental knowledge.
      • Deepen your understanding of fundamental and advanced information with an expanded collection of review questions reviewed and reorganized by chapter.
      • Master the material more easily with learning objectives, overview boxes, key words and concepts, and chapter summaries.
      • Apply what you've learned to real-life clinical situations with clinical cases in question-answer format at the end of each chapter.
      Introduction to the Kidney

      1 Physiology of Body Fluids

      Objectives
      Physicochemical Properties of Electrolyte Solutions
      Molarity and Equivalence
      Osmosis and Osmotic Pressure
      Osmolarity and Osmolality
      Tonicity
      Oncotic Pressure
      Specific Gravity
      Volumes of Body Fluid Compartments
      Composition of Body Fluid Compartments
      Fluid Exchange Between Body Fluid Compartments
      Capillary Fluid Exchange
      Cellular Fluid Exchange
      Summary
      Key Words and Concepts
      Self-Study Problems


      2 Structure and Function of the Kidneys

      Objectives
      Structure of the Kidneys
      Gross Anatomy
      Ultrastructure of the Nephron
      Ultrastructure of the Glomerulus
      Ultrastructure of the Juxtaglomerular Apparatus
      Innervation of the Kidneys
      Summary
      Key Words and Concepts
      Self-Study Problems


      3 Glomerular Filtration and Renal Blood Flow

      Objectives
      Renal Clearance
      Glomerular Filtration Rate
      Glomerular Filtration
      Determinants of Ultrafiltrate Composition
      Dynamics of Ultrafiltration
      Renal Blood Flow
      Regulation of Renal Blood Flow and Glomerular Filtration Rate
      Sympathetic Nerves
      Angiotensin II
      Prostaglandins
      Nitric Oxide
      Endothelin
      Bradykinin
      Adenosine
      Natriuretic Peptides
      ATP
      Glucocorticoids
      Histamine
      Dopamine
      Summary
      Key Words and Concepts
      Self-Study Problems


      4 Renal Transport Mechanisms: NaCl and Water Reabsorption Along the Nephron

      Objectives
      General Principles of Membrane Transport
      General Principles of Transepithelial Solute and Water Transport
      NaCl, Solute, and Water Reabsorption Along the Nephron
      Proximal Tubule
      Henle’s Loop
      Distal Tubule and Collecting Duct
      Regulation of NaCl and Water Reabsorption
      Summary
      Key Words and Concepts
      Self-Study Problems


      5 Regulation of Body Fluid Osmolality: Regulation of Water Balance

      Objectives
      Antidiuretic Hormone
      Osmotic Control of AVP Secretion
      Hemodynamic Control of AVP Secretion
      AVP Actions on the Kidneys
      Thirst
      Renal Mechanisms for Dilution and Concentration of the Urine
      The Role of Urea
      Vasa Recta Function
      Assessment of Renal Diluting and Concentrating Ability
      Summary
      Key Words and Concepts
      Self-Study Problems


      6 Regulation of Extracellular Fluid Volume and NaCl Balance

      Objectives
      Concept of Effective Circulating Volume
      Volume-Sensing Systems
      Volume Sensors in the Low-Pressure Cardiopulmonary Circuit
      Volume Sensors in the High-Pressure Arterial Circuit
      Hepatic Sensors
      Central Nervous System Na+ Sensors
      Volume Sensor Signals
      Renal Sympathetic Nerves
      Renin-Angiotensin-Aldosterone System
      Natriuretic Peptides
      AVP
      Control of Renal NaCl Excretion During Euvolemia
      Mechanisms for Maintaining Constant Na+ Delivery to the Distal Tubule
      Regulation of Distal Tubule and Collecting Duct Na+ Reabsorption
      Control of Na+ Excretion with Volume Expansion
      Control of Na+ Excretion with Volume Contraction
      Edema
      Alterations in Starling Forces
      The Role of the Kidneys
      Summary
      Key Words and Concepts
      Self-Study Problems


      7 Regulation of Potassium Balance

      Objectives
      Overview of K+ Homeostasis
      Regulation of Plasma [K+]
      Epinephrine
      Insulin
      Aldosterone
      Alterations of Plasma [K+]
      Acid-Base Balance
      Plasma Osmolality
      Cell Lysis
      Exercise
      K+ Excretion by the Kidneys
      Cellular Mechanisms of K+ Transport by Principal Cells and Intercalated Cells in the Distal Tubule and Collecting Duct
      Regulation of K+ Secretion by the Distal Tubule and Collecting Duct
      Plasma [K+]
      Aldosterone
      Arginine vasopressin (AVP)
      Factors that Perturb K+ Excretion
      Flow of Tubular Fluid
      Acid-Base Balance
      Glucocorti
      Bruce M. Koeppen, MD, PhD, Dean, Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Connecticut and Bruce A. Stanton, PhD, Andrew C. Vail Professor, Microbiology, Immunology, and Physiology, Director of the Lung Biology Center, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire

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