Cell Biology, 3rd Edition
The much-anticipated 3rd edition of Cell Biology delivers comprehensive, clearly written, and richly illustrated content to today’s students, all in a user-friendly format. Relevant to both research and clinical practice, this rich resource covers key principles of cellular function and uses them to explain how molecular defects lead to cellular dysfunction and cause human disease. Concise text and visually amazing graphics simplify complex information and help readers make the most of their study time.
- Clearly written format incorporates rich illustrations, diagrams, and charts.
- Uses real examples to illustrate key cell biology concepts.
- Includes beneficial cell physiology coverage.
- Clinically oriented text relates cell biology to pathophysiology and medicine.
- Takes a mechanistic approach to molecular processes.
- Major new didactic chapter flow leads with the latest on genome organization, gene expression and RNA processing.
- Boasts exciting new content including the evolutionary origin of eukaryotes, super resolution fluorescence microscopy, cryo-electron microscopy, gene editing by CRISPR/Cas9, contributions of high throughput DNA sequencing to understand genome organization and gene expression, microRNAs, IncRNAs, membrane-shaping proteins, organelle-organelle contact sites, microbiota, autophagy, ERAD, motor protein mechanisms, stem cells, and cell cycle regulation.
- Features specially expanded coverage of genome sequencing and regulation, endocytosis, cancer genomics, the cytoskeleton, DNA damage response, necroptosis, and RNA processing.
- Includes hundreds of new and updated diagrams and micrographs,plus fifty new protein and RNA structures to explain molecular mechanisms in unprecedented detail.
- Student Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and over a dozen animations from the book on a variety of devices.
Section 1: Introduction to Cell Biology
1 Introduction to Cells
2 Evolution of Life on Earth
Section 2: Chemical and Physical Background
3 Molecules: Structures and Dynamics
4 Biophysical Principles
5 Macromolecular Assembly
6 Research Strategies
Section 3: Chromatin, Chromosomes, and the Cell Nucleus
7 Chromosome Organization
8 DNA Packaging in Chromatin and Chromosomes
9 Nuclear Structure and Dynamics
Section 4: Central Dogma: From Gene to Protein
10 Gene Expression
11 Eukaryotic RNA Processing
12 Protein Synthesis and Folding
Section 5: Membrane Structure and Function
13 Membrane Structure and Dynamics
14 Membrane Pumps
15 Membrane Carriers
16 Membrane Channels
17 Membrane Physiology
Section 6: Cellular Organelles and Membrane Trafficking
18 Posttranslational Targeting of Proteins
19 Mitochondria, Chloroplasts, Peroxisomes
20 Endoplasmic Reticulum
21 Secretory Membrane System and Golgi Apparatus
22 Endocytosis and the Endosomal Membrane
23 Processing and Degradation of Cellular Components
Section 7: Signaling Mechanisms
24 Plasma Membrane Receptors
25 Protein Hardware for Signaling
26 Second Messengers
27 Integration of Signals
Section 8: Cellular Adhesion and the Extracellular Matrix
28 Cells of the Extracellular Matrix and Immune System
29 Extracellular Matrix Molecules
30 Cellular Adhesion
31 Intercellular Junctions
32 Connective Tissues
Section 9: Cytoskeleton and Cellular Motility
33 Actin and Actin-Binding Proteins
34 Microtubules and Centrosomes
35 Intermediate Filaments
36 Motor Proteins
37 Intracellular Motility
38 Cellular Motility
Section 10: Cell Cycle
40 Introduction to the Cell Cycle
41 G1 Phase and Regulation of Cell Proliferation
42 S Phase and DNA Replication
43 G2 Phase and Control of Entry into Mitosis
44 Mitosis and Cytokinesis
46 Programmed Cell Death
Thomas D. Pollard, MD, Sterling Professor, Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, William C. Earnshaw, PhD, FRS, Professor and Wellcome Trust Principal Research Fellow, Wellcome Trust Centre for Cell Biology, ICB, University of Edinburgh, Scotland, United Kingdom, Jennifer Lippincott-Schwartz, PhD, Group Leader, Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, Virginia, United States and Graham Johnson, MA, PhD, CMI, Director, Animated Cell, Allen Institute for Cell Biology, Seattle, Washington;, QB3 Faculty Fellow, University of California, San Francisco, San Francisco, California