cover image - Renal Physiology,6th Edition
ISBN: 9780323595681
Page Count: 248
Imprint: Elsevier
List Price: $42.99

Renal Physiology,6th Edition

by Bruce M. Koeppen, MD, PhD and Bruce A. Stanton, PhD
Paperback
cover image - Renal Physiology,6th Edition
ISBN: 9780323595681
Page Count: 248
Imprint: Elsevier
List Price: $42.99
$42.99
$34.39
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Gain a foundational understanding of renal physiology and how the renal system functions in health and disease. Renal Physiology, a volume in the Mosby Physiology Series, explains the fundamentals of this complex subject in a clear and concise manner, while helping you bridge the gap between normal kidney function and disease with pathophysiology content throughout the book.

  • INTRODUCTION

    CHAPTER 1

    PHYSIOLOGY OF BODY FLUIDS

    Objectives

    Concept of Steady-State Balance

    Physicochemical Properties of Electrolyte Solutions

    Molarity and Equivalence

    Osmosis and Osmotic Pressure

    Osmolarity and Osmolality

    Tonicity

    Oncotic Pressure

    Specific Gravity

    Volumes of Body Fluid Compartments

    Composition of Body Fluid Compartments

    Fluid Exchange between Body Fluid Compartments

    Capillary Fluid Exchange

    Cellular Fluid Exchange

    Summary

    Key Words and Concepts

    Self-Study Problems

    CHAPTER 2

    STRUCTURE AND FUNCTION OF THE KIDNEYS

    Objectives

    Structure of the Kidneys

    Gross Anatomy

    Ultrastructure of the Nephron

    Ultrastructure of the Glomerulus

    Ultrastructure of the Juxtaglomerular Apparatus

    Innervation of the Kidneys

    Summary

    Key Words and Concepts

    Self-Study Problems

    CHAPTER 3

    GLOMERULAR FILTRATION AND RENAL BLOOD FLOW

    Objectives

    Renal Clearance

    Glomerular Filtration Rate

    Glomerular Filtration

    Determinants of Ultrafiltrate Composition

    Dynamics of Ultrafiltration

    Renal Blood Flow

    Regulation of Renal Blood Flow and Glomerular Filtration Rate

    Sympathetic Nerves

    Angiotensin II

    Prostaglandins

    Nitric Oxide

    Endothelin

    Bradykinin

    Adenosine

    Natriuretic Peptides

    Adenosine Triphosphate

    Glucocorticoids

    Histamine

    Dopamine

    Summary

    Key Words and Concepts

    Self-Study Problems

    CHAPTER 4

    RENAL TRANSPORT MECHANISMS: NaCl AND WATER ABSORPTION ALONG THE NEPHRON

    Objectives

    General Principles of Membrane Transport

    General Principles of Transepithelial Solute and Water Transport

    NaCl, Solute, and Water Reabsorption Along the Nephron

    Proximal Tubule

    Henle’s Loop

    Distal Tubule and Collecting Duct

    Regulation of NaCl and Water Reabsorption

    Summary

    Key Words and Concepts

    Self-Study Problems

    CHAPTER 5

    REGULATION OF BODY FLUID OSMOLALITY: REGULATION OF WATER BALANCE

    Objectives

    Arginine Vasopressin

    Osmotic Control of Arginine Vasopressin Secretion

    Hemodynamic Control of Arginine Vasopressin Secretion

    Arginine Vasopressin Actions on the Kidneys

    Thirst

    Renal Mechanisms for Dilution and Concentration of the Urine

    Medullary Interstitium

    Vasa Recta Function

    Assessment of Renal Diluting and Concentrating Ability

    Summary

    Key Words and Concepts

    Self-Study Problems

    CHAPTER 6

    REGULATION OF EXTRACELLULAR FLUID VOLUME AND NaCl BALANCE

    Objectives

    Whole-Body Na+ Balance

    Concept of Effective Circulating Volume

    Volume-Sensing Systems

    Volume Sensors in the Low-Pressure Cardiopulmonary Circuit

    Volume Sensors in the High-Pressure Arterial Circuit

    Volume Sensor Signals

    Renal Sympathetic Nerves

    Renin-Angiotensin-Aldosterone System

    Natriuretic Peptides

    Arginine Vasopressin

    Control of Renal NaCl Excretion During Euvolemia

    Mechanisms for Maintaining Constant Na+ Delivery to the Distal Tubule in Euvolemia

    Regulation of Distal Tubule and Collecting Duct Na+ Reabsorption in Euvolemia

    Control of Na+ Excretion with Volume Expansion

    Control of Na+ Excretion with Volume Contraction

    Edema

    Alterations in Starling Forces

    Capillary Hydrostatic Pressure (Pc)

    Plasma Oncotic Pressure (πc)

    Lymphatic Obstruction

    Capillary Permeability

    Role of the Kidneys

    Summary

    Key Words and Concepts

    Self-Study Problems

    CHAPTER 7

    REGULATION OF POTASSIUM BALANCE

    Objectives

    Overview of K+ Homeostasis

    Regulation of Plasma [K+]

    Epinephrine

    Insulin

    Aldosterone

    Alterations of Plasma [K+]

    Acid-Base Balance

    Plasma Osmolality

    Cell Lysis

    Exercise

    K+ Excretion by the Kidneys

    Cellular Mechanisms of K+ Transport by Principal Cells and Intercalated Cells in the Distal Tubule and Collecting Duct

    Regulation of K+ Secretion by the Distal Tubule and Collecting Duct

    Plasma [K+]

    Aldosterone

    Arginine Vasopressin

    Factors that Perturb K+ Excretion

    Flow of Tubular Fluid

    Acid-Base Balance

    Glucocorticoids

    Summary

    Key Words and Concepts

    Self-Study Problems

    CHAPTER 8

    REGULATION OF ACID-BASE BALANCE

    Objectives

     Buffer System

    Overview of Acid-Base Balance

    Renal Net Acid Excretion

     Reabsorption Along the Nephron

    Regulation of H+ Secretion

    Formation of New

    Response to Acid-Base Disorders

    Extracellular and Intracellular Buffers

    Respiratory Compensation

    Renal Compensation

    Simple Acid-Base Disorders

    Metabolic Acidosis

    Metabolic Alkalosis

    Respiratory Acidosis

    Respiratory Alkalosis

    Analysis of Acid-Base Disorders

    Summary

    Key Words and Concepts

    Self-Study Problems

    CHAPTER 9

    REGULATION OF CALCIUM AND PHOSPHATE HOMEOSTASIS

    Objectives

    Calcium

    Overview of Ca++ Homeostasis

    Ca++ Transport Along the Nephron

    Regulation of Urinary Ca++ Excretion

    Calcium-Sensing Receptor

    Phosphate

    Overview of Pi Homeostasis

    Pi Transport Along the Nephron

    Regulation of Urinary Pi Excretion

    Integrative Review of Parathyroid Hormone and Calcitriol on Ca++ and Pi Homeostasis

    Summary

    Key Words and Concepts

    Self-Study Problems

    CHAPTER 10

    PHYSIOLOGY OF DIURETIC ACTION

    Objectives

    General Principles of Diuretic Action

    Sites of Action of Diuretics

    Response of Other Nephron Segments

    Adequate Delivery of Diuretics to Their Site of Action

    Volume of the Extracellular Fluid

    Diuretic Braking Phenomenon

    Mechanisms of Action of D

  • Bruce M. Koeppen, MD, PhD, Dean, Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Connecticut and Bruce A. Stanton, PhD, Andrew C. Vail Professor, Microbiology, Immunology, and Physiology, Director of the Lung Biology Center, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire
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