cover image - Cellular Physiology and Neurophysiology,3rd Edition
ISBN: 9780323596190
Page Count: 304
Imprint: Elsevier
List Price: $42.99

Cellular Physiology and Neurophysiology, 3rd Edition

by Mordecai P. Blaustein, MD, Joseph P. Y. Kao, PhD and Donald R. Matteson, PhD
Paperback
cover image - Cellular Physiology and Neurophysiology,3rd Edition
ISBN: 9780323596190
Page Count: 304
Imprint: Elsevier
List Price: $42.99
$42.99
$34.39
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Gain a foundational understanding of complex physiology concepts with this thoroughly revised text. Cellular Physiology and Neurophysiology, a volume in the Mosby Physiology Series, explains the fundamentals of these multi-faceted areas in a clear and concise manner. It helps bridge the gap between basic biochemistry, molecular and cell biology, and neuroscience, and organ and systems physiology, providing the rich, clinically oriented coverage needed to master the latest concepts in neuroscience and how cells function in health and disease.

  • SECTION I, Fundamental Physicochemical Concepts

    CHAPTER 1, INTRODUCTION: HOMEOSTASIS AND CELLULAR PHYSIOLOGY

    Homeostasis Enables the Body to Survive in Diverse Environments

    The Body Is an Ensemble of Functionally and Spatially Distinct Compartments

    Transport Processes Are Essential to Physiological Function

    Cellular Physiology Focuses on Membrane-Mediated Processes and on Muscle Function

    Summary

    Key Words and Concepts

    CHAPTER 2, DIFFUSION AND PERMEABILITY

    Diffusion Is the Migration of Molecules down a Concentration Gradient

    Fick’s First Law of Diffusion Summarizes our Intuitive Understanding of Diffusion

    Essential Aspects of Diffusion Are Revealed by Quantitative Examination of Random, Microscopic Movements of Molecules

    Fick’s First Law Can Be Used to Describe Diffusion across a Membrane Barrier

    Summary

    Key Words and Concepts

    Study Problems

    CHAPTER 3, OSMOTIC PRESSURE AND WATER MOVEMENT

    Osmosis Is the Transport of Solvent Driven by a Difference in Solute Concentration Across a Membrane That Is Impermeable to Solute

    Water Transport during Osmosis Leads to Changes in Volume

    Osmotic Pressure Drives the Net Transport of Water during Osmosis

    Osmotic Pressure and Hydrostatic Pressure Are Functionally Equivalent in Their Ability to Drive Water Movement Through a Membrane

    Only Impermeant Solutes Can Have Permanent Osmotic Effects

    Summary

    Key Words and Concepts

    Study Problems

    CHAPTER 4, ELECTRICAL CONSEQUENCES OF IONIC GRADIENTS

    Ions Are Typically Present at Different Concentrations on Opposite Sides of a Biomembrane

    Selective Ionic Permeability Through Membranes Has Electrical Consequences: The Nernst Equation

    The Stable Resting Membrane Potential in a Living Cell Is Established by Balancing Multiple Ionic Fluxes

    The Cell Can Change Its Membrane Potential by Selectively Changing Membrane Permeability to Certain Ions

    The Donnan Effect Is an Osmotic Threat to Living Cells

    Summary

    Key Words and Concepts

    Study Problems

    SECTION II, Ion Channels and Excitable Membranes

    CHAPTER 5, ION CHANNELS

    Ion Channels Are Critical Determinants of the Electrical Behavior of Membranes

    Distinct Types of Ion Channels Have Several Common Properties

    Ion Channels Share Structural Similarities and Can Be Grouped into Gene Families

    Summary

    Key Words and Concepts

    Study Problems

    CHAPTER 6, PASSIVE ELECTRICAL PROPERTIES OF MEMBRANES

    The Time Course and Spread of Membrane Potential Changes Are Predicted by the Passive Electrical Properties of the Membrane

    The Equivalent Circuit of a Membrane Has a Resistor in Parallel with a Capacitor

    Passive Membrane Properties Produce Linear Current-Voltage Relationships

    Membrane Capacitance Affects the Time Course of Voltage Changes

    Membrane and Axoplasmic Resistances Affect the Passive Spread of Subthreshold Electrical Signals

    Summary

    Key Words and Concepts

    Study Problems

    CHAPTER 7, GENERATION AND PROPAGATION OF THE ACTION POTENTIAL

    The Action Potential Is a Rapid and Transient Depolarization of the Membrane Potential in Electrically Excitable Cells

    Ion Channel Function Is Studied with a Voltage Clamp

    Individual Ion Channels Have Two Conductance Levels

    Na Channels Inactivate during Maintained Depolarization

    Action Potentials Are Generated by Voltage-Gated Na and K Channels

    Action Potential Propagation Occurs as a Result of Local Circuit Currents

    Summary

    Key Words and Concepts

    Study Problems

    CHAPTER 8, ION CHANNEL DIVERSITY

    Various Types of Ion Channels Help to Regulate Cellular Processes

    Voltage-Gated Ca2+ Channels Contribute to Electrical Activity and Mediate Ca2+ Entry into Cells

    Many Members of the Transient Receptor Potential Superfamily of Channels Mediate Ca2+ Entry

    K-Selective Channels Are the Most Diverse Type of Channel

    Ion Channel Activity Can Be Regulated by Second-Messenger Pathways

    Summary

    Key Words and Concepts

    Study Problems

    SECTION III, Solute Transport

    CHAPTER 9, ELECTROCHEMICAL POTENTIAL ENERGY AND TRANSPORT PROCESSES

    Electrochemical Potential Energy Drives All Transport Processes

    Summary

    Key Words and Concepts

    Study Problems

    CHAPTER 10, PASSIVE SOLUTE TRANSPORT

    Diffusion across Biological Membranes Is Limited by Lipid Solubility

    Channel, Carrier, and Pump Proteins Mediate Transport across Biological Membranes

    Carriers Are Integral Membrane Proteins That Open to Only One Side of the Membrane at a Time

    Coupling the Transport of One Solute to the "Downhill" Transport of Another Solute Enables Carriers to Move the Cotransported or Countertransported Solute "Uphill" against an Electrochemical Gradient

    Net Transport of Some Solutes across Epithelia Is Effected by Coupling Two Transport Processes in Series

    Na Is Exchanged for Solutes Such as Ca2+ and H by Countertransport Mechanisms

    Multiple Transport Systems Can Be Functionally Coupled

    Summary

    Key Words and Concepts

    Study Problems

    CHAPTER 11, ACTIVE TRANSPORT

    Primary Active Transport Converts the Chemical Energy from ATP into Electrochemical Potential Energy Stored in Solute Gradients

    The Plasma Membrane Na Pump (Na, K-ATPase) Maintains the Low Na and High K Concentrations in the Cytosol

    Intracellular Ca2+ Signaling Is Universal and Is Closely Tied to Ca2+ Homeostasis

    Several Other Plasma Membrane Transport ATPases Are Physiologically Important

    Net Transport across Epithelial Cells Depends on the Coupling of Apical and Basolateral Membrane Transport Systems

    Summary

    Key Words and Concepts

    Study Problems

    SECTION IV, Physiology of Synaptic Transmission

    CHAPTER 12, SYNAPTIC PHYSIOLOGY I

    The Synapse Is a Junction Between Cells That Is Specialized fo

  • Mordecai P. Blaustein, MD, Professor & Chairman, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, Joseph P. Y. Kao, PhD, Associate Professor, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD and Donald R. Matteson, PhD, Associate Professor, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD
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