Hematology, 8th Edition
Hardcover
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Covers all hematologic disorders, including comprehensive discussions of hematologic malignancies, individualized patient care, cell-based therapies, transplantation, transfusion medicine, hemostasis, thrombosis, and consultative hematology—in one convenient volume.
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Provides state-of-the-art guidance from global experts at the forefront of the latest research and clinical practice.
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Provides extensive updates throughout on basic science research, advances in molecular diagnostics, new drugs, immunotherapies, personalized medicine, laboratory medicine, transfusion medicine, stem cell transplantation, and clinical treatment for all hematologic malignancies and non-malignancies
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Contains new chapters on gene editing; the impact of mitochondria on hematopoiesis; myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes; immunotherapy and management of its toxicities; transfusion medicine in sickle cell disease; principles of radiation therapy; and COVID-19, including complications of vaccination and its impact on the hematologic system.
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Discusses many new advances in the field, including details and the future of gene therapy for hemophilia, gene editing for sickle cell disease and thalassemia, the evolution of cellular therapy, use of cells, transfusion medicine vs. protein therapy, gene sequencing, immunotherapy, and new targeted drugs.
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Includes more decision-making algorithms for formulating diagnoses and personalized treatment plans for those highly complex disorders that require individualized approaches.
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Addresses the effects of aging on hematopoiesis and on the manifestations of a variety of hematologic disorders.
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Discusses cardio-oncology and its impact on the treatment of patients with hematologic disorders.
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Presents relevant basic science as background for clinical application in later sections.
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An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
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PART I MOLECULAR AND CELLULAR BASIS OF HEMATOLOGY
1. Anatomy and Physiology of the Gene
2. Epigenomics in Hematology
3. Genomic Approaches to Hematology
4. Regulation of Gene Expression in Hematology
5. Genome Editing
6. Signaling Transduction and Metabolomics
7. Protein Architecture: Relationship of Form and Function
8. Pharmacogenomics and Hematologic Diseases
PART II CELLULAR BASIS OF HEMATOLOGY
9. Hematopoietic Stem Cell Biology
10. Mitochondria and Hematopoiesis
11. Cytokines, Chemokines, Other Growth Factors, and Their Receptors
12. Role of Chemokines in Leukocyte Trafficking
13. Stem Cell Model of Hematologic Diseases
14. Hematopoietic Microenvironment
15. Cell Adhesion
16. Current Biology of Stem Cell Homing and Mobilization: Dynamic Interactions Between Hematopoietic Stem and Progenitor Cells and Their Surrounding Bone Marrow Microenvironment
17. Control of Cell Division
18. Cell Death
19. Aging and Hematopoiesis
PART III IMMUNOLOGIC BASIS OF HEMATOLOGY
20. Dendritic Cell Biology
21. Natural Killer Cell Immunity and Therapy
22. B-Cell Development
23. Complement and Immunoglobulin Biology Leading to Clinical Translation
24. T-Cell Immunity
25. Unmodified Ex Vivo Expanded T Cells
26. Treatment of Hematologic Malignancies with Genetically Modified T Cells
PART IV DISORDERS OF HEMATOPOIETIC CELL DEVELOPMENT
27. Biology of Erythropoiesis, Erythroid Differentiation, and Maturation
28. Granulocytopoiesis and Monocytopoiesis
29. Thrombocytopoiesis
30. Inherited Bone Marrow Failure Syndromes
31. Aplastic Anemia
32. Paroxysmal Nocturnal Hemoglobinuria
33. Acquired Disorders of Red Cell, White Cell, and Platelet Production
PART V RED BLOOD CELLS
34. Pathobiology of the Human Erythrocyte and Its Hemoglobins
35. Approach to Anemia in the Adult and Child
36. Iron Homeostasis and Its Disorders
37. Disorders of Iron Homeostasis: Iron Deficiency and Overload
38. Anemia of Chronic Inflammation
39. Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias
40. Megaloblastic Anemias
41. Thalassemia Syndromes
42. Pathobiology of Sickle Cell Disease
43. Clinical Aspects of Sickle Cell Disease
44. Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias
45. Red Blood Cell Enzymopathies
46. Red Blood Cell Membrane Disorders
47. Autoimmune Hemolytic Anemia
48. Extrinsic Nonimmune Hemolytic Anemias
PART VI NON-MALIGNANT LEUKOCYTES
49. Neutrophilic Leukocytosis, Neutropenia, Monocytosis, and Monocytopenia
50. Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia, and Hypogammaglobulinemia
51. Disorders of Phagocyte Function
52. Congenital Disorders of Lymphocyte Function
53. Pediatric and Adult Histiocytic Disorders
54. Lysosomal Storage Diseases, Focusing on Gaucher Disease: Perspectives and Principles
55. Epstein-Barr Virus and Associated Lymphoproliferative Conditions
PART VII HEMATOLOGIC MALIGNANCIES
56. Progress in the Classification of Hematopoietic and Lymphoid Neoplasms: Clinical Implications
57. Conventional and Molecular Cytogenomic Basis of Hematologic Malignancies
58. Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies
59. Pathobiology of Acute Myeloid Leukemia
60. Clinical Manifestations and Treatment of Acute Myeloid Leukemia
61. Myelodysplastic Syndromes
62. Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults
63. Acute Myeloid Leukemia in Children
64. Blastic Plasmacytoid Dendritic Cell Neoplasm
65. Myelodysplastic Syndromes and Myeloproliferative Neoplasms in Children
66. Pathobiology of Acute Lymphoblastic Leukemia
67. Clinical Manifestations and Treatment of Childhood Acute Lymphoblastic Leukemia
68. Acute Lymphoblastic Leukemia in Adults
69. Chronic Myeloid Leukemia
70. The Polycythemias
71. Essential Thrombocythemia
72. Primary Myelofibrosis and Chronic Neutrophilic Leukemia
73. Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes
74. Eosinophilia, Eosinophilic Neoplasms, and the Hypereosinophilic Syndromes
75. Mast Cells and Mastocytosis
76. Chronic Lymphocytic Leukemia
77. Hairy Cell Leukemia
78. The Pathologic Basis for the Classification of Non-Hodgkin and Hodgkin Lymphomas
79. Origin of Hodgkin Lymphoma and Therapeutic Targets
80. Hodgkin Lymphoma
81. Origin of Non-Hodgkin Lymphoma and Therapeutic Targets
82. Clinical Manifestations, Staging, and Treatment of Follicular Lymphoma
83. Marginal Zone Lymphomas (Extranodal/MALT, Splenic, and Nodal)
84. Diffuse Large B-Cell Lymphoma of the Central Nervous System
85. High-Grade B-Cell Lymphomas
86. Mantle Cell Lymphoma
87. Virus-Associated Lymphoma
88. Malignant Lymphomas in Childhood
89. T-Cell Lymphomas
90. Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma
91. Multiple Myeloma
92. Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma
93. Immunoglobulin Light-Chain Amyloidosis (Primary Amyloidosis)
PART VIII COMPREHENSIVE CARE OF PATIENTS WITH HEMATOLOGIC MALIGNANCIES
94. Key Considerations for Managing Infections in the Compromised Host
95. Principles of Radiation Therapy for Hematologic Disease
96. Grading and Toxicity Management after Immune Effector Therapy
97. Identification and Management of Checkpoint Inhibition Toxicity
98. Psychosocial Aspects of Hematologic Disorders
99. Pain Management and Antiemetic Therapy in Hematologic Disorders
100. Palliative Care
101. Therapy-related Late Effects of Hematologic Malignancies
PART IX TRANSPLANTATION AND OTHER CELL-BASED THERAPIES
102. Practical Aspects of Hematopoietic Stem Cell Harvesting and Mobilization
103. Graft Engineering and Cell Processing
104. Principles of Cell-Based Genetic Therapies
105. Indications, Outcomes, and Donor Selection for Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies in Adults
106. Unrelated Donor Hematopoietic Cell Transplantation
107. Haploidentical Hematopoietic Stem Cell Transplantation
108. Cord Blood Transplantation
109. Graft-versus-Host Disease and Graft-versus- Leukemia Responses