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cover image - Hematology,8th Edition
ISBN: 9780323733885
Copyright: 2023
Publication Date: 12-02-2022
Page Count: 2512
Imprint: Elsevier
List Price: $419.99

Hematology, 8th Edition

by Ronald Hoffman, MD, Edward J. Benz, MD, Leslie E. Silberstein, MD, Helen Heslop, MD, Jeffrey Weitz, MD, Mohamed E. Salama, MD and Syed Ali Abutalib


cover image - Hematology,8th Edition
ISBN: 9780323733885
Copyright: 2023
Publication Date: 12-02-2022
Page Count: 2512
Imprint: Elsevier
List Price: $419.99
Important note
Please note
This item has low stock levels and may be back-ordered. We'll let you know if it is back-ordered, and you will not be charged until the item ships.
    • Covers all hematologic disorders, including comprehensive discussions of hematologic malignancies, individualized patient care, cell-based therapies, transplantation, transfusion medicine, hemostasis, thrombosis, and consultative hematology—in one convenient volume. 

    • Provides state-of-the-art guidance from global experts at the forefront of the latest research and clinical practice. 

    • Provides extensive updates throughout on basic science research, advances in molecular diagnostics, new drugs, immunotherapies, personalized medicine, laboratory medicine, transfusion medicine, stem cell transplantation, and clinical treatment for all hematologic malignancies and non-malignancies 

    • Contains new chapters on gene editing; the impact of mitochondria on hematopoiesis; myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes; immunotherapy and management of its toxicities; transfusion medicine in sickle cell disease; principles of radiation therapy; and COVID-19, including complications of vaccination and its impact on the hematologic system. 

    • Discusses many new advances in the field, including details and the future of gene therapy for hemophilia, gene editing for sickle cell disease and thalassemia, the evolution of cellular therapy, use of cells, transfusion medicine vs. protein therapy, gene sequencing, immunotherapy, and new targeted drugs. 

    • Includes more decision-making algorithms for formulating diagnoses and personalized treatment plans for those highly complex disorders that require individualized approaches. 

    • Addresses the effects of aging on hematopoiesis and on the manifestations of a variety of hematologic disorders. 

    • Discusses cardio-oncology and its impact on the treatment of patients with hematologic disorders. 

    • Presents relevant basic science as background for clinical application in later sections. 

    • An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. 

    1. Anatomy and Physiology of the Gene
    2. Epigenomics in Hematology
    3. Genomic Approaches to Hematology
    4. Regulation of Gene Expression in Hematology
    5. Genome Editing
    6. Signaling Transduction and Metabolomics
    7. Protein Architecture: Relationship of Form and Function
    8. Pharmacogenomics and Hematologic Diseases
    9. Hematopoietic Stem Cell Biology
    10. Mitochondria and Hematopoiesis
    11. Cytokines, Chemokines, Other Growth Factors, and Their Receptors
    12. Role of Chemokines in Leukocyte Trafficking
    13. Stem Cell Model of Hematologic Diseases
    14. Hematopoietic Microenvironment
    15. Cell Adhesion
    16. Current Biology of Stem Cell Homing and Mobilization: Dynamic Interactions Between Hematopoietic Stem and Progenitor Cells and Their Surrounding Bone Marrow Microenvironment
    17. Control of Cell Division
    18. Cell Death
    19. Aging and Hematopoiesis
    20. Dendritic Cell Biology
    21. Natural Killer Cell Immunity and Therapy
    22. B-Cell Development
    23. Complement and Immunoglobulin Biology Leading to Clinical Translation
    24. T-Cell Immunity
    25. Unmodified Ex Vivo Expanded T Cells
    26. Treatment of Hematologic Malignancies with Genetically Modified T Cells
    27. Biology of Erythropoiesis, Erythroid Differentiation, and Maturation
    28. Granulocytopoiesis and Monocytopoiesis
    29. Thrombocytopoiesis
    30. Inherited Bone Marrow Failure Syndromes
    31. Aplastic Anemia
    32. Paroxysmal Nocturnal Hemoglobinuria
    33. Acquired Disorders of Red Cell, White Cell, and Platelet Production
    34. Pathobiology of the Human Erythrocyte and Its Hemoglobins
    35. Approach to Anemia in the Adult and Child
    36. Iron Homeostasis and Its Disorders
    37. Disorders of Iron Homeostasis: Iron Deficiency and Overload
    38. Anemia of Chronic Inflammation
    39. Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias
    40. Megaloblastic Anemias
    41. Thalassemia Syndromes
    42. Pathobiology of Sickle Cell Disease
    43. Clinical Aspects of Sickle Cell Disease
    44. Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias
    45. Red Blood Cell Enzymopathies
    46. Red Blood Cell Membrane Disorders
    47. Autoimmune Hemolytic Anemia
    48. Extrinsic Nonimmune Hemolytic Anemias
    49. Neutrophilic Leukocytosis, Neutropenia, Monocytosis, and Monocytopenia
    50. Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia, and Hypogammaglobulinemia
    51. Disorders of Phagocyte Function
    52. Congenital Disorders of Lymphocyte Function
    53. Pediatric and Adult Histiocytic Disorders
    54. Lysosomal Storage Diseases, Focusing on Gaucher Disease: Perspectives and Principles
    55. Epstein-Barr Virus and Associated Lymphoproliferative Conditions
    56. Progress in the Classification of Hematopoietic and Lymphoid Neoplasms: Clinical Implications
    57. Conventional and Molecular Cytogenomic Basis of Hematologic Malignancies
    58. Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies
    59. Pathobiology of Acute Myeloid Leukemia
    60. Clinical Manifestations and Treatment of Acute Myeloid Leukemia
    61. Myelodysplastic Syndromes
    62. Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults
    63. Acute Myeloid Leukemia in Children
    64. Blastic Plasmacytoid Dendritic Cell Neoplasm
    65. Myelodysplastic Syndromes and Myeloproliferative Neoplasms in Children
    66. Pathobiology of Acute Lymphoblastic Leukemia
    67. Clinical Manifestations and Treatment of Childhood Acute Lymphoblastic Leukemia
    68. Acute Lymphoblastic Leukemia in Adults
    69. Chronic Myeloid Leukemia
    70. The Polycythemias
    71. Essential Thrombocythemia
    72. Primary Myelofibrosis and Chronic Neutrophilic Leukemia
    73. Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes
    74. Eosinophilia, Eosinophilic Neoplasms, and the Hypereosinophilic Syndromes
    75. Mast Cells and Mastocytosis
    76. Chronic Lymphocytic Leukemia
    77. Hairy Cell Leukemia
    78. The Pathologic Basis for the Classification of Non-Hodgkin and Hodgkin Lymphomas
    79. Origin of Hodgkin Lymphoma and Therapeutic Targets
    80. Hodgkin Lymphoma
    81. Origin of Non-Hodgkin Lymphoma and Therapeutic Targets
    82. Clinical Manifestations, Staging, and Treatment of Follicular Lymphoma
    83. Marginal Zone Lymphomas (Extranodal/MALT, Splenic, and Nodal)
    84. Diffuse Large B-Cell Lymphoma of the Central Nervous System
    85. High-Grade B-Cell Lymphomas
    86. Mantle Cell Lymphoma
    87. Virus-Associated Lymphoma
    88. Malignant Lymphomas in Childhood
    89. T-Cell Lymphomas
    90. Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma
    91. Multiple Myeloma
    92. Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma
    93. Immunoglobulin Light-Chain Amyloidosis (Primary Amyloidosis)
    94. Key Considerations for Managing Infections in the Compromised Host
    95. Principles of Radiation Therapy for Hematologic Disease
    96. Grading and Toxicity Management after Immune Effector Therapy
    97. Identification and Management of Checkpoint Inhibition Toxicity
    98. Psychosocial Aspects of Hematologic Disorders
    99. Pain Management and Antiemetic Therapy in Hematologic Disorders
    100. Palliative Care
    101. Therapy-related Late Effects of Hematologic Malignancies
    102. Practical Aspects of Hematopoietic Stem Cell Harvesting and Mobilization
    103. Graft Engineering and Cell Processing
    104. Principles of Cell-Based Genetic Therapies
    105. Indications, Outcomes, and Donor Selection for Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies in Adults
    106. Unrelated Donor Hematopoietic Cell Transplantation
    107. Haploidentical Hematopoietic Stem Cell Transplantation
    108. Cord Blood Transplantation
    109. Graft-versus-Host Disease and Graft-versus- Leukemia Responses
  • Ronald Hoffman, MD, Albert A. and Vera G. List Professor of Medicine, Tisch Cancer Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, Edward J. Benz, MD, Richard and Susan Smith Professor of Medicine, Professor of Pediatrics and Genetics, Harvard Medical School; President and CEO, Dana-Farber Cancer Institute
    Director and Principal Investigator Dana Farber/Harvard Cancer Center, Boston, Massachusetts, Leslie E. Silberstein, MD, Director, Transfusion Medicine, Professor of Pathology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachussetts, Helen Heslop, MD, Professor, Departments of Medicine and Pediatrics Section of Hematology-Oncology, Baylor College of Medicine; Dan L. Duncan Chair Director, Adult Stem Cell Transplant Program, The Methodist Hospital; Associate Director Clinical Research, Dan L. Duncan Cancer Center; Houston, Texas, Jeffrey Weitz, MD, Prof of Medicine and Biochemistry and Biomedical Sciences, McMaster University, Executive Director, Thrombosis & Atherosclerosis Research Institute (TaARI), Hamilton General Hospital, Hamilton, Ontario, Canada, Mohamed E. Salama, MD and Syed Ali Abutalib
Important note
Please note
This item has low stock levels and may be back-ordered. We'll let you know if it is back-ordered, and you will not be charged until the item ships.