Zipes and Jalife’s Cardiac Electrophysiology: From Cell to Bedside, 8th Edition

Section 1 STRUCTURAL AND MOLECULAR BASES OF ION CHANNEL FUNCTION

1. Voltage-gated sodium channels and electrical excitability of the heart

2. Voltage-gated calcium

3. Voltage-gated potassium channels

4. Structural and molecular bases of cardiac inward rectifier potassium channel function

5. Mammalian calcium pumps in health and disease

6. Structural and molecular bases of sarcoplasmic reticulum ion channel function

7. Organellar ion channels and transporters

8. Molecular organization, gating, and function of connexin-based gap junction channels and hemichannels

Section 2 BIOPHYSICS OF CARDIAC ION CHANNEL FUNCTION

9. Structure-function relations of heterotrimetric complexes of sodium channel a and β subunits

10. Regulation of cardiac calcium channels

11. Inhibition of phosphoinositide 3-kinase and acquired long QT syndrome

12. Structural determinants and biophysical properties of hERG1 channel gating

13. Molecular regulation of cardiac inward rectifier potassium channels by pharmacologic agents

14. Cardiac stretch-activated channels and mechano-electric coupling

15. Biophysical properties of gap junctions

16. Excitation-contraction coupling

Section 3 INTERMOLECULAR INTERACTIONS AND CARDIOMYOCYTE ELECTRICAL FUNCTION

17. Ion channel trafficking in the heart

18. Microdomain interactions of macromolecular complexes and regulation of the sodium channel nav1.5

19. Fibroblast growth factor homologous factors modulate cardiac calcium channels

20. Macromolecular complexes and cardiac potassium channels

21. Reciprocity of cardiac sodium and potassium channels in the control of excitability and arrhythmias

22. The intercalated disc: A molecular network that integrates electrical coupling, intercellular adhesion and cell excitability

23. Function and dysfunction of ion channel membrane trafficking and post translational modification

24. Feedback mechanisms for cardiac-specific microRNAs and cAMP signaling in electrical remodeling

Section 4 CELL BIOLOGY OF CARDIAC IMPULSE INITIATION AND PROPAGATION

25. Stem cell-derived nodal-like cardiomyocytes as a novel pharmacologic tool: Insights from sinoatrial node development and function

26. Gene therapy and biologic pacing

27. Intercellular communication and impulse propagation

28. Mechanisms of normal and dysfunctional sinoatrial nodal excitability and propagation

29. Cell biology of the specialized cardiac conduction system

30. Cardiac remodeling and regeneration

Section 5 MODELS OF CARDIAC EXCITATION

31. Ionic mechanisms of atrial action potentials

32. Genetic algorithms to generate dynamical complexity electrophysiological models

33. Calcium signaling in cardiomyocyte dodels with realistic geometries

34. Theory of rotors and arrhythmias

35. Computational approaches for accurate rotor localization in the human atria

36. Modeling the aging heart

Section 6 NEURAL CONTROL OF CARDIAC ELECTRICAL ACTIVITY

37. Innervation of the sinoatrial node

38. Mechanism for altered autonomic and oxidant regulation of cardiac sodium currents.

39. Pulmonary vein ganglia and the neural regulation of the heart rate

40. Neural activity and atrial tachyarrhythmias

41. Sympathetic innervation and cardiac arrhythmias

Section 7 ARRHYTHMIA MECHANISMS

42. The molecular pathophysiology of atrial fibrillation

43. Myofibroblasts, cytokines, and persistent atrial fibrillation

44. Role of the autonomic nervous system in atrial fibrillation

45. Rotors in human atrial fibrillation

46. Body surface frequency-phase mapping of atrial fibrillation

47. Panoramic mapping of atrial fibrillation from the body surface

48. Mechanisms of human ventricular tachycardia and human ventricular fibrillation

49. Genetics of atrial fibrillation

Section 8 MOLECULAR GENETICS AND PHARMACOGENOMICS

50. Mechanisms in heritable sodium channel diseases

51. Genetic, ionic, and cellular mechanisms underlying the J-wave syndromes

52. Inheritable potassium channel diseases

53. Inheritable phenotypes associated with altered intracellular calcium regulation

Section 9 PHARMACOLOGIC, GENETIC, AND CELL THERAPY OF ION CHANNEL DYSFUNCTION

54. Pharmacologic bases of antiarrhythmic therapy

55. Pharmacogenomics of cardiac arrhythmias

56. Gene therapy to treat cardiac arrhythmias

57. Highly mature human iPSC-derived cardiomyocytes as models for cardiac electrophysiology and drug testing

58. Cardiac repair with human induced pluripotent stem cell-derived cardiovascular cells.

Section 10 DIAGNOSTIC EVALUATION

59. Assessment of the patient with a cardiac arrhythmia

60. Electrocardiography of tachyarrhythmias: Differential diagnosis of narrow and wide QRS complex tachycardias

61. Electroanatomic mapping for arrhythmias

62. Computed tomography for electrophysiology

63. Magnetic resonance imaging for electrophysiology

64. Intracardiac echocardiography for electrophysiology

65. Exercise-induced arrhythmias

66. Cardiac monitoring: short- and long-term recording

67. Head-up tilt table testing

68. Autonomic regulation and cardiac risk

69. T-wave alternans

70. Noninvasive electrocardiographic imaging of human ventricular arrhythmias and Electrophysiological Substrate

71. Genetic testing

Section 11 SUPRAVENTRICULAR TACHYARRHYTHIAS: MECHANISMS, CLINICAL FEATURES, AND MANAGEMENT

72. Sinus node abnormalities

73. Atrial tachycardia

74. Atrial tachycardia in adults with congenital heart disease

75. Typical and atypical atrial flutter: Mapping and ablation

76. Atrial fibrillation

77. Preexcitation, atrioventricular reentry, variants

78. Electrophysiological characteristics of atrioventricular nodal reentrant tachycardia: Implications for the rentrant circuits

79. Junctional tachycardia

Section 12 VENTRICULAR TACHYCARRHYTHMIAS: MECHANISMS, CLNICAL FEATURES, AND MANAGEMENT

80. Premature ventricular complexes

Jose Jalife, MD, PhD, Distinguished Senior Investigator, Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.), Madrid, Spain. Emeritus Professor of Internal Medicine and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan. and William Gregory Stevenson, MD, Director, Cardiac Arrhythmia Program, Cardiovascular Division, Brigham and Women's Hospital; Professor of Medicine Harvard Medical School, Boston, MA