Diagnostic Pathology : Hepatobiliary and Pancreas, 3rd Edition
Hardcover
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Analyzes hundreds of diagnoses, each of which include critical diagnostic information such as definitions, epidemiology, clinical presentation, macro- and microscopic features, differential diagnoses, and pathologic interpretation pearls.
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Features thorough updates throughout, including novel immunohistochemical markers and other ancillary techniques (such as BAP1, INSM1, Rb, albumin in situ hybridization) that play an increasingly critical role in improving diagnoses
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Addresses recent advances in molecular pathology—new diagnostic, immunohistochemical, molecular, and genetic techniques used for diagnosis, as well as new details about the genesis and activity of tumors in the liver, pancreas, and biliary systems
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Includes details from the 2019 WHO Classification of Tumors of the Digestive System regarding important changes to diagnostic techniques, identification of new variants of cancers, and immunohistochemical markers and ancillary techniques that improve diagnosis and treatment options
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Reflects recent WHO updates and updates from the AJCC’s 8th Edition Cancer Staging Manual such as new terminology, new grading of neuroendocrine tumors and neuroendocrine carcinomas, and characteristic molecular alterations in hepatocellular adenoma, cholangiocarcinoma, and other tumors
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Uses a templated page layout, bulleted text, and a generous number of high-quality images to help practicing and in-training pathologists reach a confident diagnosis
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Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices
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SECTION 1: LIVER
INHERITED, METABOLIC, AND DEVELOPMENTAL DISORDERS
4 Glycogen Storage Disease, Hepatic
Joseph Misdraji, MD, Lisa Yerian, MD, and Grace E. Kim, MD
10 Tyrosinemia
Joseph Misdraji, MD
12 Niemann-Pick Disease
Joseph Misdraji, MD
14 Gaucher Disease
Joseph Misdraji, MD
16 Neonatal Hemochromatosis
Joseph Misdraji, MD
18 Porphyrin Metabolism Disorders
Maria Westerhoff, MD and Joseph Misdraji, MD
24 Dubin-Johnson Syndrome
Joseph Misdraji, MD and Sanjay Kakar, MD
26 Gilbert Disease
Joseph Misdraji, MD and Sanjay Kakar, MD
28 Progressive Familial Intrahepatic Cholestasis
Joseph Misdraji, MD
36 Cystic Fibrosis, Hepatic
Joseph Misdraji, MD
40 Hereditary Hemochromatosis
Joseph Misdraji, MD and Laura W. Lamps, MD
44 Wilson Disease
Joseph Misdraji, MD and Laura W. Lamps, MD
50 Alpha-1-Antitrypsin Deficiency
Nicole C. Panarelli, MD, Kari D. Caradine, MD, and Laura
W. Lamps, MD
54 Congenital Hepatic Fibrosis
Romil Saxena, MBBS, MD, FRCPath (UK) and Hanlin L. Wang, MD, PhD
56 Polycystic Liver Disease
Romil Saxena, MBBS, MD, FRCPath (UK) and Hanlin L. Wang, MD, PhD
58 Caroli Disease
Romil Saxena, MBBS, MD, FRCPath (UK)
INFECTIOUS DISORDERS
60 Overview of Hepatitis
Nicole C. Panarelli, MD and Laura W. Lamps, MD
66 Acute Viral Hepatitis
Nicole C. Panarelli, MD and Lisa Yerian, MD
70 Hepatitis B
Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD
74 Hepatitis C
Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD
78 Hepatitis E
Maria Westerhoff, MD
82 Epstein-Barr Virus
Laura W. Lamps, MD, Maria Westerhoff, MD, and Hanlin
L. Wang, MD, PhD
86 Cytomegalovirus
Laura W. Lamps, MD
88 Herpes Simplex Virus
Sanjay Kakar, MD
90 Adenovirus
Maria Westerhoff, MD and Hanlin L. Wang, MD, PhD
92 Pyogenic Abscess
Laura W. Lamps, MD
96 Sepsis in Liver
Laura W. Lamps, MD
98 Mycobacterium tuberculosis
Laura W. Lamps, MD
102 Atypical Mycobacteria
Laura W. Lamps, MD
106 Cat-Scratch Disease
Laura W. Lamps, MD
108 Candidiasis
Laura W. Lamps, MD
110 Histoplasmosis
Joseph Misdraji, MD and Laura W. Lamps, MD
114 Cryptococcosis
Laura W. Lamps, MD
116 Amebiasis
Laura W. Lamps, MD
120 Schistosomiasis
Laura W. Lamps, MD
122 Echinococcosis
Laura W. Lamps, MDCHRONIC CHOLESTATIC AND AUTOIMMUNE DISORDERS
124 Autoimmune Hepatitis
Nicole C. Panarelli, MD and Lisa Yerian, MD
130 Primary Biliary Cholangitis
Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD
136 Primary Sclerosing Cholangitis
Hanlin L. Wang, MD, PhD
142 Ischemic Cholangitis
Maria Westerhoff, MD and Lisa Yerian, MD
144 Large Bile Duct Obstruction
Maria Westerhoff, MD and Laura W. Lamps, MD
148 Idiopathic Adulthood Ductopenia
Hanlin L. Wang, MD, PhD
PEDIATRIC CHOLESTATIC DISORDERS
150 Biliary Atresia
Romil Saxena, MBBS, MD, FRCPath (UK), Grace E. Kim, MD, and Matthew M. Yeh, MD, PhD
154 Idiopathic Neonatal Hepatitis
Romil Saxena, MBBS, MD, FRCPath (UK), Grace E. Kim, MD, and Matthew M. Yeh, MD, PhD
156 Syndromic Paucity of Intrahepatic Bile Ducts
(Alagille Syndrome)
Joseph Misdraji, MD, Romil Saxena, MBBS, MD, FRCPath (UK), and Matthew M. Yeh, MD, PhD
160 Nonsyndromic Paucity of Intrahepatic Bile Ducts
Romil Saxena, MBBS, MD, FRCPath (UK), Joseph Misdraji, MD, and Matthew M. Yeh, MD, PhD
DRUG/TOXIN-RELATED HEPATITIS
164 Drug-Related Acute Hepatitis
Sanjay Kakar, MD
170 Drug-Induced Acute Hepatic Failure
Sanjay Kakar, MD
174 Drug-Induced Cholestatic Liver Injury
Sanjay Kakar, MD
176 Drug-Related Granulomatous Hepatitis
Laura W. Lamps, MD
180 Drug-Related Steatohepatitis/Phospholipidosis
Laura W. Lamps, MD
184 Reye Syndrome
Romil Saxena, MBBS, MD, FRCPath (UK) and Lisa Yerian, MD
186 Drug-Related Cholangitis/Ductopenia
Maria Westerhoff, MD
192 Hepatic Stellate Cell Hyperplasia
Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD
FATTY LIVER DISEASES
194 Alcoholic Liver Disease
Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD
200 Nonalcoholic Steatohepatitis
Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD
208 Glycogenic Hepatopathy
Maria Westerhoff, MD and Lisa Yerian, MD
210 Fatty Liver of Pregnancy
Nicole C. Panarelli, MD and Lisa Yerian, MDVASCULAR DISORDERS
212 Portal Venous Obstruction
Hanlin L. Wang, MD, PhD
214 Hepatoportal Sclerosis
Hanlin L. Wang, MD, PhD
216 Hepatic Venous Outflow Obstruction
Sanjay Kakar, MD
220 Venoocclusive Disease
Sanjay Kakar, MD
222 Amyloidosis
Sanjay Kakar, MD
224 Ischemia
Rondell Graham, MBBS and Lisa Yerian, MD
226 Nodular Regenerative Hyperplasia
Sanjay Kakar, MD
TRANSPLANTATION PATHOLOGY
228 Ischemia Reperfusion Injury
Romil Saxena, MBBS, MD, FRCPath (UK) and Hanlin L. Wang, MD, PhD
230 Antibody-Mediated Rejection
Hanlin L. Wang, MD, PhD and Romil Saxena, MBBS, MD, FRCPath (UK)
232 T-Cell-Mediated Rejection (Acute Cellular Rejection)
Romil Saxena, MBBS, MD, FRCPath (UK)
236 Chronic Rejection
Romil Saxena, MBBS, MD, FRCPath (UK) and Matthew M. Yeh, MD, PhD
238 Central Perivenulitis/Parenchymal Rejection
Rondell Graham, MBBS
240 Hepatic Artery Thrombosis
Rondell Graham, MBBS and Lisa Yerian, MD
242 Graft-vs.-Host Disease
Rondell Graham, MBBS and Lisa Yerian, MD
TUMORS OF THE LIVER
244 Hepatic Adenoma
Sanjay Kakar, MD and Matthew M. Yeh, MD, PhD
252 Focal Nodular Hyperplasia
Sanjay Kakar, MD
256 Regenerative and Dysplastic Nodules
Sanjay Kakar, MD
262 Hepatocellular Carcinoma and Variants
Sanjay Kakar, MD
274 Fibrolamellar Carcinoma
Rondell Graham, MBBS
278 Combined Hepatocellular-Cholangiocarcinoma
Maria Westerhoff, MD
282 Hepatoblastoma
Rondell Graham, MBBS
286 Bile Duct Adenoma
Rondell Graham, MBBS and Sanjay Kakar, MD
288 von Meyenburg Complex (Biliary Microhamartoma) Sanjay Kakar, MD, Laura W. Lamps, MD, and Rondell Graham, MBBS
290 Mucinous Cystic Neoplasm, Liver
Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD
294 Intrahepatic Cholangiocarcinoma
Rondell Graham, MBBS and Sanjay Kakar, MD
298 Intrahepatic Cholangiocarcinoma Histologic Subtypes
Rondell Graham, MBBS
302 Intraductal Papillary Neoplasm
Rondell Graham, MBBS
304 Hemangioma
as described in our 