Weight Regulation and Curing Acquired Obesity
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Addressing the problem of how weight is regulated, how obesity is acquired, and how it is cured, Weight Regulation and Curing Acquired Obesity provides the mathematical basis of control system theory as applied to weight regulation. Unlike the majority of weight control literature which focuses on biochemistry, this innovative title discusses the biomechanical aspects of a dual closed loop system which mechanically senses meal volume and accumulated intraabdominal fat, where accurate sensation depends on the mechanical strength of the anterior abdominal wall.
Chapter 1 The Basics The fat distribution ratio and energy storage as fat are described. The triad of .5 liters of fat = 1 pound of fat = 3500 Kcals is introduced. Chapter 2 Control System Theory The mathematical basis of closed loop control system is discussed. A control system that regulates fat volume will regulate fat weight. Chapter 3 Satiety Satiety is achieved by volume loading. Intraganglion laminar ending within the stomach wall senses the tension from food within the stomach and accumulated intra-abdominal fat. Chapter 4 Serendipity The clinical observation that satiety is achieved with smaller meal volume resulting in weight lost after abdominal wall reinforcement with mesh is described. Chapter 5 The Neuromechanical Hypothesis Fat weight is regulated by a dual closed loop control system. The fast loop controls meal volume and the slow loop regulates fat weight. Chapter 6 Animal Experiments and Human Studies Animal experiments performed by Dr. Koopman supports the fast loop component of the hypothesis and disproves the biochemical hypothesis. Human studies support the slow loop hypothesis. Chapter 7 Energy Fat volume regulation results in fat energy regulation which is essential for survival. The three components of energy expenditure are described. Chapter 8 Acquired Obesity Decreased mechanical strength of the anterior abdominal wall is the cause of the current epidemic of acquired obesity. Analogies are made between the mechanical failure of overstretched springs to the mechanical failure of the fascia of the anterior abdominal wall. Chapter 9 Curing Acquired Obesity Prevention, treatment and cure of acquired obesity are described with comparisons made between the current bariatric surgical procedures and the new alternatives. An obesity treatment algorithm is provided. Chapter 10 The Future Future animal and human studies can be performed to support the neuromechanical hypothesis. Future treatment will be directed to specifically correct the pathology of the anterior abdominal wall and core exercise to maintain it.
Gary Horndeski, M.D. and Elisa Gonzalez, P.A.-C