Diagnostic Pathology: Spleen, 2nd Edition

by Aaron Auerbach, MD, MPH and Nadine Aguilera, MD

Hardcover

ISBN: 9780323830126

Publication Date: 03-04-2022

Page Count: 556

Imprint: Elsevier

List Price: $262.99

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This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of splenic pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the 2nd edition of Diagnostic Pathology: Spleen is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource.

Key Features
- Provides essential knowledge focused entirely on splenic pathology, including immunohistochemistry, flow cytometry, and molecular testing as they relate to splenic lesions and their differential diagnoses
- Presents up-to-date information on splenic injury and laceration grading and management, the findings of next-generation sequencing studies, and a range of molecularly defined genetic alterations of spleen neoplasms
- Features an Antibody Index and Molecular Factors Index to assist with identification and diagnosis
- Includes 14 new chapters covering topics such as autoimmune disease involving the spleen, spleen anatomy, splenic microcirculation, immune function of the spleen, spleen imaging, leukemic non-nodal mantle cell lymphoma, Tay-Sachs disease, normal T-cell subsets, and many others
- Includes approximately 2,000 high-quality clinical and histologic images, gross pathology images, radiologic images, and full-color illustrations to help practicing and in-training pathologists reach a confident diagnosis
- Includes updated criteria, terminology, and classifications from the 2017 World Health Organization Classification of Lymphoid Neoplasms
- Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care
- Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices
Contents

SECTION 1: HISTOLOGY, FUNCTION, AND DEVELOPMENT OF SPLEEN

NORMAL HISTOLOGY

4 Introduction to Spleen

Mohammad A. Vasef, MD and Jeremy C. Wallentine, MD

12 Imaging of Splenic Disorders

Mohammad A. Vasef, MD

18 Handling, Processing, and Gross Pathology of Spleen

Mohammad A. Vasef, MD

26 Fine-Needle Aspiration and Core Biopsy of Spleen

Mohammad A. Vasef, MD

32 Immunohistochemistry of Spleen

Aaron Auerbach, MD, MPH

40 Flow Cytometry

Nadine Aguilera, MD

46 Molecular Techniques

Nadine Aguilera, MD

SECTION 2: NONNEOPLASTIC SPLENIC DISORDERS

LYMPHOID HYPERPLASIA

54 Florid Follicular Hyperplasia

Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH

56 Autoimmune Disease

Nadine Aguilera, MD

62 HIV in Spleen

Nadine Aguilera, MD

68 Castleman Disease

Nadine Aguilera, MD

70 Marginal Zone Hyperplasia

Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH

GRANULOMATOUS LESIONS/DISORDERS

72 Lipogranulomas

Jeffrey Vos, MD

78 Sarcoidosis

Ellina Hall, DO and Aaron Auerbach, MD, MPH

82 Chronic Granulomatous Disease

Aaron Auerbach, MD, MPH

INFECTIONS

86 Mycobacteriosis

Nadine Aguilera, MD

90 Selected Bacterial Infections

Aaron Auerbach, MD, MPH

94 Candidiasis

Aaron Auerbach, MD, MPH

96 Histoplasmosis

Nadine Aguilera, MD

98 Cryptococcosis

Nadine Aguilera, MD

100 Coccidioidomycosis

Aaron Auerbach, MD, MPH

104 Pneumocystosis

Aaron Auerbach, MD, MPH

108 Infectious Mononucleosis

Nadine Aguilera, MD

112 Cytomegalovirus Infection

Nadine Aguilera, MD

114 Herpes Simplex Virus Infection

Aaron Auerbach, MD, MPH and Nadine Aguilera, MD

116 Echinococcosis

Aaron Auerbach, MD, MPH

120 Malaria

Nadine Aguilera, MD

NONINFECTIOUS CYSTS

122 Epithelial Cyst

Ellina Hall, DO and Aaron Auerbach, MD, MPH

124 False Cyst

Ellina Hall, DO and Aaron Auerbach, MD, MPH

NONNEOPLASTIC VASCULAR PROCESSES

126 Chronic Passive Congestion

Ellina Hall, DO and Aaron Auerbach, MD, MPH

128 Infarct

Jeffrey Vos, MD

136 Peliosis

Ellina Hall, DO and Aaron Auerbach, MD, MPH

138 Sclerosing Angiomatoid Nodular Transformation Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD

RED CELL DISORDERS

144 Sickle Cell Disease

Aaron Auerbach, MD, MPH and Ellina Hall, DO

146 Thalassemia

Nadine Aguilera, MD and Aaron Auerbach, MD, MPH

150 Hereditary Spherocytosis

Nadine Aguilera, MD

152 Thrombotic Thrombocytopenic Purpura

Aaron Auerbach, MD, MPH

MISCELLANEOUS LESIONS/DISORDERS

158 Heterotaxy Syndromes

Aaron Auerbach, MD, MPH

160 Congenital Splenic Abnormalities

Nadine Aguilera, MD

164 Extramedullary Hematopoiesis

Ellina Hall, DO and Aaron Auerbach, MD, MPH

166 Gamna-Gandy Bodies

Nadine Aguilera, MD

168 Hemophagocytic Lymphohistiocytosis

Nadine Aguilera, MD

174 Immune Thrombocytopenic Purpura

Ellina Hall, DO and Aaron Auerbach, MD, MPH

178 Niemann-Pick Disease

Meenakshi A. Nandedkar, MD and Nadine Aguilera, MD

184 Gaucher Disease

Meenakshi A. Nandedkar, MD and Nadine Aguilera, MD

188 Sea-Blue (Ceroid) Histiocytosis

Mohammad A. Vasef, MD

192 Gangliosidosis Lysosomal Disorder

Mohammad A. Vasef, MD

194 Therapy Effect on Spleen

Aaron Auerbach, MD, MPH

202 Traumatic and Nontraumatic Splenic Injuries

Mohammad A. Vasef, MD

SECTION 3: NEOPLASTIC SPLENIC DISORDERS

BENIGN MESENCHYMAL LESIONS

208 Introduction to Vascular Lesions

Nadine Aguilera, MD

210 Hemangioma

Nadine Aguilera, MD

218 Lymphangioma

Nadine Aguilera, MD

222 Littoral Cell Angioma

Nadine Aguilera, MD

228 Inflammatory Pseudotumor

Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD

236 Postchemotherapy Histiocyte-Rich Pseudotumor of Spleen

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

242 Splenic Hamartoma

Nadine Aguilera, MD

246 Myelolipoma

Aaron Auerbach, MD, MPH

MALIGNANT OR POTENTIALLY MALIGNANT MESENCHYMAL LESIONS

248 Angiosarcoma

Nadine Aguilera, MD

256 Hemangioendothelioma

Nadine Aguilera, MD

258 Kaposi Sarcoma

Nadine Aguilera, MD

260 Leiomyosarcoma

Aaron Auerbach, MD, MPH

266 Gastrointestinal Stromal Tumor

Aaron Auerbach, MD, MPH

272 Follicular Dendritic Cell Sarcoma

Aaron Auerbach, MD, MPH

280 Inflammatory Pseudotumor-Like Follicular Dendritic Cell Sarcoma

Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD

286 Langerhans Cell Histiocytosis

Guanghua Wang, MD

292 Histiocytic Sarcoma

Nadine Aguilera, MD

LYMPHOMA

300 Introduction to Lymphoma

Mohammad A. Vasef, MD

310 Splenic Marginal Zone Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

318 Hairy Cell Leukemia

Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD

326 Hairy Cell Leukemia Variant

Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD

334 Lymphoplasmacytic Lymphoma

Aaron Auerbach, MD, MPH
Authors

Aaron Auerbach, MD, MPH, Senior Hematopathologist, Joint Pathology Center, Silver Spring, Maryland, USA and Nadine Aguilera, MD, Professor, Department of Pathology, Section Head, Hematopathology, University of Virginia Health System, Charlottesville, Virginia.