Section 1 Mechanisms of Drug Action and Therapeutic Principles1. IntroductionSusan L. Ingram and Lynn Wecker2. Pharmacodynamics: Receptors and Concentration-Response Relationships JoAnn Trejo, Laura M. Bohn and James Carlton Garrison II3. PharmacokineticsNamandje Bumpus and Paul Hollenberg4. PharmacogenomicsLarisa Cavallari, Scott A. Mosley and Emily J. Cicali5. Drug Discovery, Development and Regulation Felix Kim, Lance McMahon, James Barrett, Samuel Obeng and Christopher McCurdySection 2 Chemical Mediators and Drugs Affecting Autonomic and Neuromuscular Synapses6. Introduction to the Autonomic Nervous SystemMarsha L. Pierce and Lynn WeckerCholinergic Drugs7. Muscarinic Agonists, Cholinesterase Inhibitors and Their Clinical UsesNaoto Hoshi and Frederick J. Ehlert8. Muscarinic Antagonists and Their Clinical UsesNaoto Hoshi and Frederick J. Ehlert9. Nicotinic Agonists and Their Clinical UsesMarsha L. Pierce and Lynn Wecker10. Neuromuscular Blocking Drugs and Nicotinic AntagonistsMarsha L. Pierce and Lynn WeckerAdrenergic Drugs11. Adrenergic Agonists and Their Clinical UsesJavier Cuevas12. Adrenergic Antagonists and Their Clinical UsesJavier CuevasSection 3 Drug Treatment for Disorders Affecting the Central Nervous System13. The Central Nervous SystemSusan L. Ingram and Lynn Wecker14. Drug Therapy for Alzheimer's Disease and Other Cognitive Disorders/DementiasMichael S. Jaffee, Steven Trent DeKosky, Meredith Wicklund and Benjamin Albert Chapin15. Pharmacotherapy of Basal Ganglia Disorders: Parkinson Disease and Huntington DiseaseSamba Reddy and Juan R. Sanchez-Ramos16. Drug Therapy for Psychoses and Bipolar DisorderGlenn Catalano, Deborah L. Sanchez, Lynn Wecker and Cory M. Klippel17. Drug Therapy for Depression and AnxietyGlenn Catalano, Deborah L. Sanchez, Lynn Wecker and Greg Sullivan18. Drug Therapy for the Management of Attention Deficit-Hyperactivity DisorderSamba Reddy19. Drug Therapy for Insomnia and the HypersomniasMiranda Lim and Lynn Wecker20. Drug Therapy for Managing Obesity and Eating DisordersCharles Rudick21. Treatment of Seizure DisordersMichael A. Rogawski22. Drug Therapy for Spasticity DisordersSamba Reddy23. Ethanol, Other Alcohols and Drugs for Alcohol Use DisorderJesse D. Hinckley and christian J. Hopfer24. Illicit Psychoactive Compounds and Substance Use DisorderJeffery Block and Rex M. PhilpotSection 4 Drug Therapy for Pain Management25. IntroductionSusan L. Ingram26. General AnestheticsJeffrey J. Pasternak and Tasha L. Welch27. Local AnestheticsGuy Weinberg and Joshua Edwards28. Opioid AnalgesicsSusan L. Ingram and Elena Bagley29. Nonsteroidal Anti-inflammatory Agents and AcetaminophenJennelle Durnett Richardson and Jill Fehrenbacher30. Cannabinoids as AnalgesicsJeffery Block, Rex M. Philpot and Lynn Wecker31. Drug Therapy for Migraine HeadacheSamba ReddySection 5 Treatment of Inflammatory, Allergic and Immunologic Disorders32. Drug Therapy for Gout and HyperuricemiaAngelo Gaffo and Keith Elmslie33. Drug Therapy for Allergic ReactionsAnnette Gilchrist and Angela Karash34. Immunosuppressants for Autoimmune Disorders and Organ TransplantationKymberly Gowdy, Mythili Chunduru and Jennifer Ferrante35. Drug Therapy for Rheumatoid ArthritisMichelle Jane Ormseth and Keith ElmslieSection 6 Drug Treatment for Cardiovascular Diseases36. Introduction to the Regulation of Cardiovascular FunctionBeth A. Habecker, David A. Taylor, Abdel A. Abdel-Rahman and Steven E. Mansoor37. Overview of Hypertension Management and Drugs That Decrease Sympathetic ToneJames A. McCormick, David A. Taylor and Abdel A. Abdel-Rahman38. Diuretics and Drugs That Affect Volume and Electrolyte ContentJames A. McCormick and Abdel A. Abdel-Rahman39. Drugs Affecting the Renin-Angiotensin- Aldosterone SystemVardan T. Karamyan and Abdel A. Abdel-Rahman40. Calcium Channel BlockersKelly Karpa and Ryan Wilson41. Vasodilators for Hypertensive Crises, Pulmonary Hypertension and Erectile DysfunctionDavid Anthony Tulis and David S. Middlemas42. Drug Therapy for Hyperlipidemias and Atherosclerotic Cardiovascular DiseaseDan F. McCune, Michael T. Piascik and Robert Hadley43. Drug Therapy for Myocardial Ischemia and Angina PectorisDavid A. Taylor and J. West Paul44. Treatment of Heart FailureAshley Guillory, Michael T. Piascik and Robert Hadley45. Antiarrhythmic DrugsDavid A. Taylor and Stephanie W. Watts46. Anticoagulant, Antiplatelet and Fibrinolytic MedicationsKent Vrana, Kelly Karpa, Frank Herrmann and Paul T. Kocis47. Drug Therapy for Hemophilia and the Deficiency AnemiasPamela E. Potter and David A. TaylorSection 7 Treatment of Endocrine Disorders48. Introduction to Endocrine PharmacologyJames O'Donnell49. Treatment of Hypothalamic and Pituitary DisordersMichael Fay50. The Pharmacology of Adrenocorticosteroid DisordersJames O'Donnell and Gerald B. Call51. Female Hormone RegulationDavid S. Middlemas52. Androgens, Antiandrogens, and Their Clinical UsesDavid S. Middlemas53. Drug Therapy for the Management of DiabetesPhillip Kopf and Julio A. Copello54. Drug Therapy for the Management of Thyroid DisordersMichael Fay55. Calcium Regulating Hormones and Other Agents Affecting BoneMichael FaySection 8 ChemotherapyInfectious Diseases56. Principles of Antimicrobial UseRukiyah Van Dross-Anderson and Eman Soliman57. Drugs Targeting Bacterial Cell Walls and MembranesRukiyah Van Dross-Anderson and Daniel Ladin58. Drugs Targeting Bacterial Protein SynthesisRukiyah Van Dross-Anderson and Daniel Ladin59. Drugs Targeting Bacterial DNARukiyah Van Dross-Anderson and Eman Soliman60. Antimycobacterial AgentsRukiyah Van Dross-Anderson and Eman Soliman61. Drug Targeting Resistant OrganismsRukiyah Van Dross-Anderson and Daniel LadinParasitic Diseases62. Antifungal AgentsMona McConnaughey63. Antimalarial and Other Antiprotozoal AgentsJoseph Stone Stone Doggett64. Antihelmintics and EctoparasiticidesMona McConnaugheyViruses65. Antiviral AgentsMichael Teng66. Antiretroviral Drugs for HIVAmy WeckerCancer67. Principles of Antineoplastic Drug UseStephanie Huang, John Stephen Lazo, Yingbo Huang and Robert Gruener68. Cytotoxic AgentsJian-Ting Zhang, Amit Tiwari and Mary-Ann Bjornsti69. Targeted Anticancer AgentsJian-Ting Zhang, Amit Tiwari and Jill Marie Siegfried70. Immunological and cell-based therapiesAhmad Tarhini and Turkan.Ozturk TopcuSection 9 Special Considerations71. Therapeutic Use of Hematopoietic Growth FactorsPamela E. Potter72. Gastrointestinal Disorders and T
Neil P. Sheth, MD, FACS, Chief, Department of Orthopaedic Surgery, Pennsylvania Hospital; Director of Global Orthopaedics (www.globalortho.org); Site Director Pennsylvania Hospital – Adult Hip and Knee Reconstruction Fellowship; Assistant Professor, University of Pennsylvania Department of Orthopaedic Surgery, Philadelphia, Pennsylvania, Ajay Premkumar, MD, MPH, Resident, Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, New York, Michael Cross, MD, Hospital for Special Surgery and Alejandro Gonzalez Della Valle, MD, Hospital for Special Surgery
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