Diagnostic Pathology: Blood and Bone Marrow, 3rd Edition

SECTION 1: INTRODUCTION
4 Hematopoiesis and Bone Marrow Histology
Kathryn Foucar, MD
14 Bone Marrow Examination and Techniques
Kathryn Foucar, MD and Kaaren K. Reichard, MD
26 Synoptic/Integrated Bone Marrow Reporting and Algorithmic Testing
Amer Mahmoud, MD, FCAP and Cordelia Sever, MD, FCAP
30 Overview of Constitutional and Acquired Bone Marrow Disorders
Kathryn Foucar, MD

SECTION 2: ANEMIA

38 Overview of Anemia
Kathryn Foucar, MD

ACQUIRED ANEMIAS
44 Anemias of Inflammation, Chronic Kidney Disease, and Cancer
Qian-Yun Zhang, MD, PhD
48 Iron Deficiency Anemia
Qian-Yun Zhang, MD, PhD
52 Autoimmune Hemolytic Anemias
Qian-Yun Zhang, MD, PhD
58 Alloimmune Hemolytic Anemia and Hemolytic Disease of Newborn
Qian-Yun Zhang, MD, PhD
62 Microangiopathic Hemolytic Anemia
Qian-Yun Zhang, MD, PhD, Jay S. Raval, MD, and Marian Rollins-Raval, MD, MPH
68 Megaloblastic Anemia
Kristin Hunt Karner, MD and Daniel Babu, MD
76 Acquired Nonneoplastic Sideroblastic Anemia
Brittany Coffman, MD and Kaaren K. Reichard, MD
80 Alcoholism-Associated Anemia
Brittany Coffman, MD, Kathryn Foucar, MD, and Kaaren K. Reichard, MD
84 Anemia in Older Adults
Kathryn Foucar, MD
88 Copper Deficiency-Associated Anemia
Carla S. Wilson, MD, PhD
92 Acquired Red Cell Aplasia
Kristin Hunt Karner, MD
96 Transient Erythroblastopenia of Childhood
Kathryn Foucar, MD
98 Parvovirus-Induced Red Cell Aplasia
Kristin Hunt Karner, MD
102 Paroxysmal Nocturnal Hemoglobinuria
Kristin Hunt Karner, MD
108 Acquired Aplastic Anemia
Kathryn Foucar, MD and David R. Czuchlewski, MD

CONSTITUTIONAL ANEMIAS

112 Thalassemia
Kristin Hunt Karner, MD
118 Sickle Cell Anemia
Kristin Hunt Karner, MD
122 Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency
Brittany Coffman, MD and Kathryn Foucar, MD
124 Pyruvate Kinase Deficiency
Kristin Hunt Karner, MD
126 Hereditary Spherocytosis
Carla S. Wilson, MD, PhD
132 Hereditary Elliptocytosis, Including Hereditary Pyropoikilocytosis
Brittany Coffman, MD, Kathryn Foucar, MD, and Kaaren K. Reichard, MD
136 Diamond-Blackfan Anemia
David R. Czuchlewski, MD
140 Fanconi Anemia
David R. Czuchlewski, MD
144 Congenital Dyserythropoietic Anemia
Kathryn Foucar, MD
150 Congenital Sideroblastic Anemia
David R. Czuchlewski, MD
154 Congenital Megaloblastic Anemia
David R. Czuchlewski, MD

SECTION 3: ERYTHROCYTOSIS

CONSTITUTIONAL

162 Congenital Erythrocytosis
David R. Czuchlewski, MD

ACQUIRED
166 Acquired Erythrocytosis
Kathryn Foucar, MD

SECTION 4: BENIGN LEUKOCYTE DISORDERS IN BLOOD AND BONE MARROW

172 Overview of Benign Leukocyte Disorders in Blood and Bone Marrow
Kathryn Foucar, MD
176 Pancytopenia
Kathryn Foucar, MD
184 Neutropenia
Kathryn Foucar, MD
190 Neutrophilia
Kathryn Foucar, MD
196 Monocytosis
Carla S. Wilson, MD, PhD
202 Eosinophilia
Carla S. Wilson, MD, PhD
210 Basophilia
Kathryn Foucar, MD
212 Lymphocytosis
Qian-Yun Zhang, MD, PhD
216 Lymphopenia, Constitutional and Acquired
Qian-Yun Zhang, MD, PhD
220 Plasmacytosis of Bone Marrow
Kathryn Foucar, MD
228 Hematogones in Bone Marrow
Devon Chabot-Richards, MD and Kaaren K. Reichard, MD
238 Lymphoid Aggregates in Bone Marrow
Kathryn Foucar, MD and Kaaren K. Reichard, MD
246 Granulomas in Bone Marrow
Kathryn Foucar, MD

SECTION 5: CONSTITUTIONAL GRANULOCYTIC DISORDERS

CONSTITUTIONAL NEUTROPENIAS

254 Severe Congenital Neutropenia and Cyclic Neutropenia
David R. Czuchlewski, MD
258 Shwachman-Diamond Syndrome
David R. Czuchlewski, MD
262 Chediak-Higashi Syndrome
David R. Czuchlewski, MD
266 Myelokathexis in WHIM Syndrome
Kathryn Foucar, MD

CONSTITUTIONAL NEUTROPHIL ANOMALIES

270 Pelger-Huët Anomaly
Kathryn Foucar, MD
274 MYH9-Related Disorders
David R. Czuchlewski, MD
278 Selected Lysosomal Storage Diseases With Abnormal Leukocyte Granulation
David R. Czuchlewski, MD

SECTION 6: MEGAKARYOCYTIC DISORDERS

286 Overview of Megakaryocytic Disorders
Kathryn Foucar, MD, Marian Rollins-Raval, MD, MPH, and Kaaren K. Reichard, MD

ACQUIRED PLATELET DISORDERS WITH THROMBOCYTOPENIA

296 Immune-Mediated Thrombocytopenia
Kristin Hunt Karner, MD
302 Hemolytic Uremic Syndrome
Kristin Hunt Karner, MD
308 Heparin-Induced Thrombocytopenia (HIT)
Marian Rollins-Raval, MD, MPH and Evelyn L. Lockhart, MD, MScBMC
312 Thrombotic Thrombocytopenic Purpura
Kristin Hunt Karner, MD, Jay S. Raval, MD, and Marian Rollins-Raval, MD, MPH
316 Pregnancy-Associated Thrombocytopenia
Kathryn Foucar, MD, Marian Rollins-Raval, MD, MPH, and Evelyn L. Lockhart, MD, MScBMC

CONSTITUTIONAL PLATELET DISORDERS WITH THROMBOCYTOPENIA

320 Thrombocytopenia Absent Radius Syndrome
David R. Czuchlewski, MD
324 Congenital Amegakaryocytic Thrombocytopenia
David R. Czuchlewski, MD
328 Gray Platelet Syndrome
David R. Czuchlewski, MD
332 Wiskott-Aldrich Syndrome-Related Disorders
David R. Czuchlewski, MD
336 Congenital Thrombotic Thrombocytopenic Purpura
David R. Czuchlewski, MD

THROMBOCYTOSIS

340 Thrombocytosis
Kristin Hunt Karner, MD

SECTION 7: INFECTIONS

346 Overview of Infections
Carla S. Wilson, MD, PhD and Karissa Culbreath, PhD, D(ABMM)
350 Hantavirus Pulmonary Syndrome
Carla S. Wilson, MD, PhD
354 Human Immunodeficiency Virus
Karissa Culbreath, PhD, D(ABMM) and Carla S. Wilson, MD, PhD
364 Infectious Mononucleosis Syndromes (Epstein-Barr Virus, Cytomegalovirus)
Karissa Culbreath, PhD, D(ABMM) and Carla S. Wilson, MD, PhD
374 Parvovirus B19 Infection
Carla S. Wilson, MD, PhD
378 Bacterial Infections, Blood and Bone Marrow Features
Karissa Culbreath, PhD, D(ABMM) and Carla S. Wilson, MD, PhD
388 Fungal Infections, Blood and Bone Marrow Features
Mohammad A. Vasef, MD
394 Helminthic Infections
Carla S. Wilson, MD, PhD and Karissa Culbreath, PhD, D(ABMM)
398 Malaria
Carla S. Wilson, MD, PhD
406 Other Protozoan Infections
Karissa Culbreath, PhD, D(ABMM), Kathryn Foucar, MD, and Carla S. Wilson, MD, PhD
412 COVID-19 Infection (SARS-CoV-2)
Daniel Babu, MD, Kathryn Foucar, MD, and Karissa Cul

Kathryn Foucar, MD, Distinguished Professor Emerita of Pathology, Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico