Robert M. Kliegman, MD, Professor & Chair Emeritus, Department of Pediatrics - Medical College of Wisconsin Nelson Undiagnosed & Rare Disease Program, Joseph St. Geme, MD, Chair, Department of Pediatrics, Professor of Pediatrics and Microbiology, Perelman School of Medicine at the University of Pennsylvania; Physician-in-Chief, Leonard and Madlyn Abramson Endowed Chair in Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, Nathan J Blum, MD, Chief, Division of Developmental and Behavioral Pediatrics, Director, Leadership Education in Neurodevelopmental Disabilities Program, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, Robert C. Tasker, MA, MD, MBBS, Professor of Neurology and Anaesthesia (Pediatrics) Chair in Neurocritical Care, Senior Associate Staff Physician Department of Anesthesiology, Perioperative and Pain Medicine Division of Critical Care Boston Children’s Hospital Boston, MA, Shawn L Ralston, MD, MA, MS, Chief Medical Quality Officer Johns Hopkins Children’s Center Vice Chair of Quality, Safety & Service Department of Pediatrics Johns Hopkins University School of Medicine and Matthew Deardorff, MD PhD