This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Edited by Drs. Susan C. Lester and Beth T. Harrison, it is uniquely organized by the questions surgeons pose during intraoperative consultations, such as Is the bronchial margin positive or negative? or Can this liver be used for transplantation? among many others. This fully updated volume is the most comprehensive and targeted resource available in this time-sensitive area, covering more than 70 questions supported by tables, diagrams, radiographs, and photographs. Concisely written and easy to use, the third edition of Diagnostic Pathology: Intraoperative Consultation is a visually stunning, one-stop resource for every practicing pathologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.
Contains new chapters on the evaluation of margins from cervical resections, the use of ex vivo microscopy to image fresh tissue for the rapid creation of digital microscopic images for intraoperative diagnosis, and on other emerging techniques that may replace frozen section
Includes a revised Safety Precautions chapter with details on evaluating specimens from patients with COVID-19
Features updated images and text throughout to align with updated terminology and methods
Includes videos showing special techniques such as identifying radioactive seeds in breast biopsies and evaluating lung margins containing staples by frozen section
Provides updated and expanded introductory and methods chapters in addition to more than 70 chapters based on questions posed by surgeons during intraoperative consultations
Features more than 2,500 print and online images, including carefully annotated histology and gross pathology photos, full-color illustrations, clinical photographs, and radiologic images to help practicing and in-training pathologists reach a confident diagnosis
Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care
Includes an eBook version that enables you to access all text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud
SECTION 1: OVERVIEW 4 Intraoperative Consultation: Introduction Susan C. Lester, MD, PhD 10 Quality Assurance David P. Frishberg, MD 20 Safety Precautions 28 Telepathology 34 Emerging Alternatives to Frozen Section Diagnosis 38 Ex Vivo Microscopy Misha Movahed-Ezazi, MD and Matija Snuderl, MD
SECTION 2: METHODS 46 Gross Examination 54 Cytologic Examination David P. Frishberg, MD and Kristine Astvatsaturyan, MD 72 Frozen Section 80 Slide Preparation 86 Tissue Allocation for Biorepositories and Special Studies Deborah A. Dillon, MD 90 Radioactive Seed Localization Beth T. Harrison, MD 94 Lymph Nodes: Molecular Methods for Evaluation
SECTION 3: INTRAOPERATIVE CONSULTATIONS 98 Adrenal Medulla and Paraganglia: Diagnosis Vania Nosé, MD, PhD 104 Adrenal Cortex: Diagnosis 112 Anterior Mediastinal Mass: Diagnosis Matthew R. Lindberg, MD 118 Appendix: Diagnosis Amitabh Srivastava, MD 122 Bone Lesion/Tumor: Diagnosis and Margins 132 Breast: Diagnosis 138 Breast: Parenchymal Margins 142 Breast: Nipple Margin Evaluation 146 Bronchus and Trachea: Diagnosis 148 Cerebellum and Brainstem: Diagnosis Benjamin Liechty, MD, Matija Snuderl, MD, and Rebecca D. Folkerth, MD 158 Cerebral Hemispheres: Diagnosis 170 Cerebral Hemispheres: Evaluation for Epilepsy Matija Snuderl, MD, Olga Krasnozhen-Ratush, MD, and Rebecca D. Folkerth, MD 176 Cervical Trachelectomy: Margins Charles Matthew Quick, MD 178 Colon: Diagnosis and Margins 182 Colon: Evaluation for Hirschsprung Disease Karen S. Thompson, MD 188 Esophagus: Diagnosis and Margins 194 Fallopian Tube: Diagnosis 200 Head and Neck Mucosa: Diagnosis and Margins Vickie Y. Jo, MD and Jeffrey F. Krane, MD, PhD 204 Kidney, Adult: Diagnosis and Margins Roni Michelle Cox, MD 216 Kidney: Evaluation of Allograft Prior to Transplantation Lynn D. Cornell, MD 222 Kidney Needle Biopsy: Evaluation for Adequacy 226 Kidney, Pediatric: Indications and Utility 234 Larynx: Diagnosis and Margins Vickie Y. Jo, MD, Stefan Kraft, MD, and Jeffrey F. Krane, MD, PhD 238 Liver, Capsular Mass: Diagnosis 240 Liver: Evaluation of Allograft Prior to 246 Liver, Intrahepatic Mass: Diagnosis and Margins 250 Lung, Ground-Glass Opacities and Small Masses: Image-Guided Resection Matthew R. Lindberg, MD and Lucian R. Chirieac, MD 258 Lung: Margins 264 Lung, Nonneoplastic Diffuse Disease: Diagnosis 268 Lung Mass: Diagnosis 276 Lymph Nodes, Axillary: Diagnosis 284 Lymph Nodes Below Diaphragm: Diagnosis 292 Lymph Nodes: Diagnosis of Suspected Lymphoproliferative Disease Emily F. Mason, MD, PhD 302 Lymph Nodes, Head and Neck: Diagnosis 308 Lymph Nodes, Mediastinal: Diagnosis 316 Meninges: Diagnosis Benjamin Liechty, MD and Matija Snuderl, MD 326 Nasal/Sinus: Diagnosis of Suspected Fungal Rhinosinusitis 330 Nasal/Sinus: Diagnosis of Suspected Neoplasia 338 Oropharynx and Nasopharynx: Diagnosis and Margins 342 Ovary, Mass: Diagnosis Beth T. Harrison, MD and Charles Matthew Quick, MD 358 Pancreas, Biopsy: Diagnosis 362 Pancreas Resection: Parenchymal, Retroperitoneal, and Bile Duct Margins 370 Parathyroid Gland: Diagnosis and Margins 380 Peripheral Nerve and Skeletal Muscle: Allocation of Tissue for Special Studies Matija Snuderl, MD, Rebecca D. Folkerth, MD, and Rolf Pfannl, MD 382 Peritoneal/Omental Mass: Biopsy 394 Pituitary: Diagnosis 406 Pleura: Diagnosis 410 Revision Arthroplasty: Evaluation of Infection 412 Salivary Gland: Diagnosis and Margins 420 Skin: Diagnosis and Margins David Cassarino, MD, PhD 426 Skin: Evaluation for Toxic Epidermal Necrolysis vs. Staphylococcal Scalded Skin Syndrome 428 Skin: Mohs Micrographic Surgery Christine J. Ko, MD and David Cassarino, MD, PhD 434 Soft Tissue: Evaluation for Necrotizing Fasciitis 436 Soft Tissue Mass: Diagnosis and Margins 440 Spinal Cord: Diagnosis Matija Snuderl, MD and Benjamin Liechty, MD 446 Stomach: Diagnosis and Margins 450 Thyroid: Diagnosis 462 Ureter: Margins 470 Uterus, Endometrium: Diagnosis 476 Uterus, Endometrium: Diagnosis of Pregnancy 480 Uterus, Myometrium: Diagnosis 486 Vulva: Diagnosis and Margins
Susan C. Lester, MD, PhD, Former Chief of Breast Pathology Services, Brigham and Women’s Hospital, Associate Professor, Harvard Medical School, Boston, Massachusetts, USA and Beth T. Harrison, MD, Associate Pathologist, Brigham and Women's Hospital, Assistant Professor, Harvard Medical School, Boston, Massachusetts
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