cover image - Brenner & Rector's The Kidney (2 volume set), 12th Edition
ISBN: 9780443106415
Copyright: 2027
Publication Date: 03-17-2026
Page Count: 2896
Imprint: Elsevier
List Price: $524.99

Brenner & Rector's The Kidney (2 volume set), 12th Edition

by Valerie Luyckx, MBBCh, MSc, Glenn M. Chertow, MD, Philip A. Marsden, MD, Karl Skorecki, MD, FRCP(C), FASN, Maarten W. Taal, MBChB, MMed, MD, FCP(SA), FRCP and Alan S.L. Yu, MD

Hardcover

cover image - Brenner & Rector's The Kidney (2 volume set), 12th Edition
ISBN: 9780443106415
Copyright: 2027
Publication Date: 03-17-2026
Page Count: 2896
Imprint: Elsevier
List Price: $524.99

$524.99

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Long considered the definitive reference for nephrology practitioners and fellows, Brenner & Rector's The Kidney, marks its 50th anniversary with the publication of this 12th Edition. This two-volume masterwork provides expert, well-illustrated information on everything from basic science and pathophysiology to clinical best practices, covering the total patient population from preconception to the elderly. More than 200 expert contributors from 20 countries representing six continents provide a truly global perspective on the treatment and management of renal diseases.
    • Addresses current issues such as advancements in the understanding and treatment of glomerular diseases, global considerations in treating and managing kidney disease, acute kidney injury, and kidney transplantation
    • Includes new chapters on Infection-related Glomerulonephritis; IgA Nephropathy and IgA Vasculitis; Point-of-Care Ultrasound; Chronic Kidney Disease of Unknown Etiology; Kidney Lesions Associated with Dysproteinemias; Nephrotic Syndrome; Disaster Nephrology; and Sex, Gender, and Kidney Health
    • Offers significantly revised content on complement-mediated GN and thrombotic microangiopathies, genetics of kidney disease, and nephrotic syndrome: primary and secondary
    • Contains hundreds of full-color, high-quality photographs as well as carefully chosen figures, algorithms, and tables that illustrate essential concepts, nuances of clinical presentation and technique, and clinical decision making
    • Twelve new videos included in the Point-of Care chapter provide expert guidance on technique and interpretation of findings
    • Features quick reference features such as Key Points boxes in each chapter, and Clinical Relevance boxes that highlight information you must know during a patient visit, such as pertinent physiology or pathophysiology
    • Includes board review-style questions to help you prepare for certification or recertification
    • Offers an authoritative, international perspective from a world-renowned editor and contributor team
    • Provides nephrologists, fellows, renal nurses, and other health care providers with a complete, trustworthy resource, covering basic science, pathophysiology, and diagnosis and treatment
    • An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date
  • VOLUME 1
    SECTION: NORMAL STRUCTURE AND FUNCTION

    1. Embryology of the Kidney
    2. Anatomy of the Kidney
    3. Renal Circulation and Glomerular Filtration
    4. Glomerular Cell Biology and Podocytopathies
    5. Kidney Metabolism
    6. Transport of Sodium, Chloride, and Potassium
    7. Transport of Calcium, Magnesium, and Phosphate
    8. Renal Handling of Organic Solutes
    9. Renal Acidification Mechanisms
    10. Urine Concentration and Dilution
    11. Vasoactive Molecules and the Kidney
    12. Aldosterone and Mineralocorticoid Receptors: Renal and Extrarenal Roles

    SECTION II DISORDERS OF BODY FLUID VOLUME AND COMPOSITION
    13. Disorders of Sodium Balance
    14. Disorders of Water Balance
    15. Disorders of Acid-Base Balance
    16. Disorders of Potassium Balance
    17. Disorders of Calcium, Magnesium, and Phosphate Balance

    SECTION III EPIDEMIOLOGY AND RISK FACTORS IN KIDNEY DISEASE
    18. Epidemiology of Kidney Disease
    19. Risk Prediction in Chronic Kidney Disease
    20. Early Life Origins of Hypertension and Chronic Kidney Disease
    21. The Physiology and Pathophysiology of the Kidneys in Aging
    22. Sex and Gender in Kidney Health and Disease

    SECTION IV EVALUATION OF THE PATIENT WITH KIDNEY DISEASE
    23. Laboratory Assessment of Kidney Disease: Glomerular Filtration Rate, Proteinuria, and Urinalysis
    24. Diagnostic Kidney Imaging
    25. The Renal Biopsy
    26. Point-of-Care Ultrasound

    SECTION V DISORDERS OF KIDNEY STRUCTURE AND FUNCTION
    27. Pathophysiology of Acute Kidney Injury
    28. Prevention and Management of Acute Kidney Injury
    29. Pathophysiology of Proteinuria
    30. Nephrotic Syndrome: Primary and Secondary
    31. Lupus Nephritis and Other Kidney Manifestations of Systemic Inflammatory and Autoimmune Diseases
    32. Antineutrophil Cytoplasmic Antibody–Associated Vasculitis and Antiglomerular Basement Membrane Disease
    33. IgA Nephropathy and IgA Vasculitis
    34. Infection-Related Glomerulonephritis
    35. Kidney Lesions Associated With Dysproteinemias
    36. Complement-Mediated Kidney Diseases
    37. Tubulointerstitial Diseases
    38. Urinary Tract Infection in Adults
    39. Urinary Tract Obstruction
    40. Nephrolithiasis
    41. Diabetic Kidney Disease
    42. Cardiovascular Disease in Persons With Chronic Kidney Disease
    43. Kidney Cancer

    VOLUME 2
    SECTION VI GENETICS OF KIDNEY DISEASE

    44. Genetics of Kidney Disease
    45. Cystic Kidney Diseases

    SECTION VII HYPERTENSION AND THE KIDNEY
    46 Primary and Secondary Hypertension
    47. Renovascular Hypertension and Ischemic Nephropathy
    48. Antihypertensive Therapy
    49. Diuretics

    SECTION VIII CONSEQUENCES OF CHRONIC KIDNEY DISEASE
    50. Mechanisms of Progression in Chronic Kidney Disease
    51. The Pathophysiology of Uremia
    52. Chronic Kidney Disease–Mineral Bone Disorder
    53. Hematologic Aspects of Kidney Disease

    SECTION IX MANAGEMENT OF CHRONIC KIDNEY DISEASE
    54. Classification and Management of Chronic Kidney Disease
    55. Dietary Approaches to Kidney Diseases
    56. Drug Dosing Considerations in Patients With Acute Kidney Injury and Chronic Kidney Disease
    57. Onconephrology: Kidney Disease and Cancer
    58. Pregnancy and Kidney Disease
    59. Infectious Diseases and the Kidney
    60. Care of the Older Adult With Chronic Kidney Disease
    61. Kidney Supportive Care in Advanced Chronic Kidney Disease

    SECTION X DIALYSIS AND EXTRACORPOREAL THERAPIES
    62. Hemodialysis
    63. Peritoneal Dialysis
    64. Critical Care Nephrology
    65. Therapeutic Plasma Exchange and Other Extracorporeal Treatments in Management of Kidney and Related Diseases
    66. Enhanced Elimination of Poisons
    67. Interventional Nephrology: Managing Dialysis Access and Kidney Biopsy

    SECTION XI KIDNEY TRANSPLANTATION
    68. The Immunobiology of Transplantation
    69. Clinical Management of the Adult Kidney Transplant Recipient
    70. Considerations in Living Kidney Donation

    SECTION XII PEDIATRIC NEPHROLOGY
    71. Childhood Kidney Disease
    72. Kidney Replacement Therapy (Dialysis and Transplantation) in Children

    SECTION XIII GLOBAL CONSIDERATIONS IN KIDNEY DISEASE
    73. Global Challenges and Progress in Kidney Health
    74. Global Considerations in Kidney Disease: Latin America
    75. Global Considerations in Kidney Disease: Africa
    76. Global Considerations in Kidney Disease: Near and Middle East
    77. Global Considerations in Kidney Disease: Indian Subcontinent
    78. Global Considerations in Kidney Disease: The Far East
    79. Global Considerations in Kidney Disease: The Pacific Islands and Islands of the Caribbean

    SECTION XIV CHALLENGES IN NEPHROLOGY
    80. Ethical Dilemmas Facing Nephrology
    81. Health Disparities in Nephrology
    82. Disaster Nephrology
    83. Chronic Kidney Disease of Uncertain Etiology
    84. Stem Cells, Kidney Regeneration, and Gene and Cell Therapy in Nephrology
  • Valerie Luyckx, MBBCh, MSc, Affiliate Lecturer, Renal Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, Institute of Biomedical Ethics and the History of MedicineUniversity of Zurich, Zurich, Switzerland, Glenn M. Chertow, MD, Norman S. Coplon/ Satellite Healthcare, Professor of Medicine, Chief, Division of Nephrology, Stanford University School of Medicine, Stanford, Palo Alto, California, USA, Philip A. Marsden, MD, Professor of Medicine, Elisabeth Hofmann Chair in Translational Research, Oreopoulos-Baxter Division Director of Nephrology; Vice Chair Research, Department of Medicine, University of Toronto, Toronto, Ontario, Canada, Karl Skorecki, MD, FRCP(C), FASN, Annie Chutick Professor and Chair in Medicine (Nephrology), Technion-Israel Institute of Technology, Director of Medical and Research Development, Rambam Health Care Campus, Haifa, Israel, Maarten W. Taal, MBChB, MMed, MD, FCP(SA), FRCP, Professor of Medicine, Division of Medical Sciences and Graduate Entry Medicine, University of Nottingham; Honorary Consultant Nephrologist, Department of Renal Medicine, Royal Derby Hospital, Derby, UK and Alan S.L. Yu, MD, Harry Statland and Solon Summerfield Professor of Medicine, Director, Division of Nephrology and Hypertension and the Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, USA
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