Pathophysiology - Elsevier E-Book on VitalSource, 8th Edition

UNIT I Pathophysiologic Processes
1 Introduction to Pathophysiology
Framework for Pathophysiology
Concepts of Normality in Health and Disease
Epidemiology

2 Homeostasis Allostasis and Adaptive Responses to Stressors
Homeostasis and Allostasis
Stress as a Concept
Neurohormonal Mediators of Stress and Adaptation
Adaptation Coping and Illness

UNIT II Cellular Function
3 Cell Structure and Function
Plasma Membrane
Organization of Cellular Compartments
Cellular Metabolism
Functions of the Plasma Membrane
Intercellular Communication and Growth

4 Cell Injury Aging and Death
Reversible Cell Injury
Cellular Adaptation
Irreversible Cell Injury
Etiology of Cellular Injury
Aging
Somatic Death

5 Genome Structure Regulation and Tissue Differentiation
Structure and Function of Deoxyribonucleic Acid
Regulation of the Genome
Differentiation of Tissues

6 Genetic and Developmental Disorders
Principles of Inheritance
Genetic Disorders
Chromosomal Abnormalities
Mendelian Single-Gene Disorders
Nonmendelian Single-Gene Disorders
Polygenic and Multifactorial Disorders
Environmentally Induced Congenital Disorders
Diagnosis Counseling and Gene Therapy

7 Neoplasia
Benign Versus Malignant Growth
Epidemiology and Cancer Risk Factors
Genetic Mechanisms of Cancer
Multistep Nature of Carcinogenesis
Invasion and Metastasis
Effects of Cancer On the Body
Cancer Therapy

UNIT III Defense
8 Infectious Processes
Host-Microbe Relationship
Transmission of Infection
Types of Pathogenic Organisms

9 Inflammation and Immunity
Components of the Immune System
Epithelial Barriers
Mononuclear Phagocyte System
Lymphoid System
Leukocytes
Chemical Mediators of Immune Function
Innate Defenses and Inflammation
Inflammation
Healing
Inflammatory Exudates
Systemic Manifestations of Inflammation
Specific Adaptive Immunity
Major Histocompatibility Complex
Antigen Presentation By Major Histocompatibility Complex
Mechanisms of Cell-Mediated Immunity
Mechanisms of Humoral Immunity
Antibody Structure
Passive and Active Immunity
Integrated Function and Regulation of the Immune System
Integrated Response to Microbial Antigen
Integrated Response to Viral Antigen
Regulation of Immune Function

10 Alterations in Immune Function
Excessive Immune Responses
Autoimmunity
Hypersensitivity
Deficient Immune Responses
Primary Immunodeficiency Disorders
Secondary Immunodeficiency Disorders

11 Malignant Disorders of White Blood Cells
Classification of Hematologic Neoplasms
Etiology of Myeloid and Lymphoid Neoplasms
General Principles of Management
Myeloid Neoplasms
Lymphoid Neoplasms

12 HIV Disease and Aids
Epidemiology
Etiology
Pathogenesis
Diagnostic Testing
Monitoring the Progression of HIV
Clinical Manifestations
Treatment

UNIT IV Oxygen Transport Blood Coagulation Blood Flow and Blood Pressure
13 Alterations in Oxygen Transport
Composition of Blood
Structure and Function of Red Blood Cells
Gas Transport and Acid-Base Balance
Anemia
Anemia Related to Decreased Red Cell Production
Anemia Related to Inherited Disorders of the Red Cell
Anemia Related to Extrinsic Red Cell Destruction or Loss
Polycythemia

14 Alterations in Hemostasis and Blood Coagulation
The Process of Hemostasis
Evaluation of Hemostasis and Coagulation
Vascular and Platelet Disorders
Coagulation Disorders

15 Alterations in Blood Flow
Organization of the Circulatory and Lymphatic Systems
Principles of Flow
Control of Flow
General Mechanisms that Cause Altered Flow
Alterations in Arterial Flow
Alterations in Venous Flow
Alterations in Lymphatic Flow

16 Alterations in Blood Pressure
Arterial Blood Pressure
Mechanisms of Blood Pressure Regulation
Hypertension
Low Blood Pressure

UNIT V Cardiac Function
17 Cardiac Function
Cardiovascular Anatomy
Cardiac Cycle
Coronary Circulation
Cardiac Myocytes
Molecular Basis of Contraction
Cardiac Energy Metabolism
Cardiac Electrophysiology
Electrocardiography
Determinants of Cardiac Output
Endocrine Function of the Heart
Tests of Cardiac Function

18 Alterations in Cardiac Function
Coronary Heart Disease
Endocardial and Valvular Diseases
Myocardial Diseases
Pericardial Diseases
Congenital Heart Diseases

19 Heart Failure and Dysrhythmias
Heart Failure
Cardiac Dysrhythmias

20 Shock
Pathogenesis of Shock
Types of Shock
Assessment and Hemodynamic Monitoring
Complications of Shock

UNIT VI Respiratory Function
21 Respiratory Function and Alterations in Gas Exchange
Functional Anatomy
Ventilation
Pulmonary Blood Flow
Diffusion and Transport of Respiratory Gases
Alterations in Pulmonary Function
Diagnostic Tests
Alterations in Pulmonary Vasculature
Pulmonary Malignancies

22 Obstructive Pulmonary Disorders
Obstruction From Conditions in the Wall of the Lumen
Obstruction Related to Loss of Lung Parenchyma
Obstruction of the Airway Lumen

23 Restrictive Pulmonary Disorders
Lung Parenchyma Disorders
Atelectatic Disorders
Pleural Space Disorders
Neuromuscular Chest Wall and Obesity Disorders
Infection or Inflammation of the Lung

UNIT VII Fluid Electrolyte and Acid-Base Homeostasis
24 Fluid and Electrolyte Homeostasis and Imbalances
Body Fluid Homeostasis
Fluid Imbalances
Principles of Electrolyte Homeostasis
Electrolyte Imbalances

25 Acid-Base Homeostasis and Imbalances
Linda Felver
Acid-Base Homeostasis
Acid-Base Imbalances

UNIT VIII Renal and Bladder Function
26 Renal Function
Renal Anatomy
Overview of Nephron Structure and Function
Regulation of Glomerular Filtration
Transport Across Renal Tubules
Regulation of Blood Volume and Osmolality
Endocrine Functions
Age-Related Changes in Renal Function
Tests of Renal Structure and Function

27 Intrarenal Disorders
Common Manifestations of Kidney Disease

Jacquelyn L. Banasik, PhD, ARNP, Associate Professor, WSU Intercollegiate College of Nursing, Washington State University, Spokane, WA, USA