by A. Wesley Burks, MD, Robyn E. O'Hehir, FRACP, PhD, FRCPath, David H. Broide, Leonard B. Bacharier, MD, Gurjit K. Khurana Hershey, MD, PhD, R. Stokes Peebles, Jr., MD, Stephen R. Durham and Mübeccel Akdis, MD, PhD
Hardcover
ISBN: 9780443249723
Copyright: 2027
Page Count: 1840
Imprint: Elsevier
List Price: $369.99
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As both a practical reference for clinicians and researchers and an effective self-assessment tool for board preparation, Middleton's Allergy: Principles and Practice remains the #1 authoritative resource in the field. This fully revised 10th Edition brings you up to date with recent advancements in basic science and clinical applications regarding allergy practice and disease mechanisms, offering unparalleled guidance on the full spectrum of allergy across the lifespan.
Uses a concise, logically organized, and consistent chapter structure, with each chapter featuring an opening outline and Summary of Important Concepts box—all designed to make this comprehensive text easily navigable for learning, research, and clinical application
Contains new content on COVID-19, vaccines, the microbiome, and allergic diseases as related to the effects of climate change, as well as thorough updates throughout the text
Addresses recent innovations in the diagnosis, prevention, and management of allergic disorders, including emerging global issues, the advent of precision medicine, and new immunologic therapies
Features 730+ full-color illustrations and offers even more multiple-choice questions online with answers and explanations for effective, efficient self-assessment and study
Shares the experience and knowledge of a highly renowned editorial board led by Drs. A. Wesley Burks and Robyn E. O’Hehir in coordination with Drs. David H. Broide, Leonard B. Bacharier, Gurjit K. Khurana Hershey, and R. Stokes Peebles, Jr. The 10th Edition expands its international perspective with the addition of two new esteemed editors: Drs. Stephen Durham of UK and Mübeccel Akdis of Switzerland
An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date
Contributors Foreword Preface VOLUME 1 SECTION A Basic Sciences Underlying Allergy and Immunology 1 Innate Immunity 2 Adaptive Immunity 3 Immunoglobulin Structure and Function 4 Immune Tolerance 5 Cytokines in Allergic Inflammation 6 Cellular Adhesion in Inflammation 7 Chemokines 8 The Complement System 9 Lipid Mediators of Hypersensitivity and Inflammation 10 Molecular Biology and Genetic Engineering 11 Biology of Lymphocytes 12 Innate Lymphoid Cells 13 Antigen Presenting Dendritic Cells 14 Biology of Mast Cells and Their Mediators 15 Biology of Basophils 16 Biology of Eosinophils 17 Biology of Neutrophils 18 Biology of Monocytes and Macrophages 19 Airway Epithelial Cells 20 Airway Smooth Muscle in Asthma 21 Pathophysiology of Allergic Inflammation 22 Genetics and Epigenetics in Allergic Diseases 23 Omic and Systems Biology Approaches to Allergic Disease 24 Immunobiology of IgE and IgE Receptors 25 Neuronal Control of Airway Function in Allergy SECTION B Aerobiology and Allergens 26 The Structure and Function of Allergens 27 Aerobiology of Outdoor Allergens 28 Indoor Allergens 29 Preparation and Standardization of Allergens and Allergen Extracts 30 Air Pollution: Indoor and Outdoor SECTION C The Skin 31 Structure of the Skin and Cutaneous Immunology 32 Atopic Dermatitis 33 Contact Dermatitis 34 Urticaria and Angioedema 35 Hereditary Angioedema and Bradykinin‑Mediated Angioedema 36 Immune Complexes in Disease SECTION D The Eye 37 Allergic Diseases of the Eye SECTION E Respiratory Tract 38 The Nose and Control of Nasal Airflow 39 Allergic and Nonallergic Rhinitis 40 Rhinosinusitis and Nasal Polyps 41 Development, Structure, and Physiology in Normal Lung and in Asthma 42 Respiratory Tract Mucosal Immunology 43 Airway Mucus and the Mucociliary System 44 Epidemiology of Asthma and Allergic Diseases 45 Ontogeny of Immune Development and Its Relationship to Allergic Diseases and Asthma 46 Climate Change: Allergic Diseases and Asthma 47 Mouse Models of Allergic Airways Disease 48 Diagnosis of Asthma in Infants and Children 49 Management of Asthma in Infants and Children 50 Diagnosis of Asthma in Adults 51 Management of Asthma in Adolescents and Adults 52 Emergency Treatment and Approach to the Patient With Acute Asthma 53 Approach to the Patient With Exercise‑Induced Bronchoconstriction 54 Asthma and Allergic Diseases During Pregnancy 55 Occupational Allergy and Asthma 56 Pathology of Asthma 57 Allergic Bronchopulmonary Aspergillosis, Hypersensitivity Pneumonitis, and Epidemic Thunderstorm Asthma 58 Immunologic Nonasthmatic Diseases of the Lung 59 Approaches to the Patient With Chronic Cough 60 Bronchial and Nasal Challenge Testing 61 Lung Imaging 62 Pharmaceutical Aerosols and Aerosol Drug Delivery Systems VOLUME 2 SECTION F Gastrointestinal Tract 63 Gastrointestinal Mucosal Immunology 64 Eosinophilic Gastrointestinal Disorders SECTION G Systemic Disease 65 Clinical Significance of Immunoglobulin E 66 In Vivo Methods for the Study and Diagnosis of IgE‑Mediated Allergy 67 Approach to the Patient With Recurrent Infections 68 Primary Immunodeficiency Diseases 69 Treatment of Primary Immunodeficiency Diseases 70 HIV Infection and Allergic Disease 71 Laboratory Tests for Allergic and Immunodeficiency Diseases 72 Eosinophilia and Eosinophil‑Related Disorders 73 Mastocytosis 74 Anaphylaxis 75 Insect Allergy 76 Drug Allergy 77 Hypersensitivity to Aspirin and Other Nonsteroidal Antiinflammatory Drugs 78 Reactions to Foods 79 Oral Food Challenge Testing 80 Food Allergy Management, Prevention, and Therapy 81 Adverse Reactions to Vaccines SECTION H Therapeutics 82 Allergen Immunotherapy for Inhalant Allergens 83 Principles of Pharmacotherapeutics 84 Precision Medicine in Allergic Disorders 85 Optimizing Adherence in Practice 86 Anti–Immunoglobulin E Therapy 87 Cytokine‑Specific Therapy in Asthma 88 Histamine and Antihistamines 89 Inhaled β2‑Agonists 90 Anticholinergic Therapies 91 Glucocorticoids 92 Antileukotriene Therapy in Asthma 93 Unconventional Theories and Unproven Methods in Allergy 94 Complementary and Integrative Health
A. Wesley Burks, MD, Dean, UNC School of Medicine; CEO of UNC Health, The University of North Carolina at Chapel Hill, USA, Robyn E. O'Hehir, FRACP, PhD, FRCPath, Alfred Hospital and Monash University, Department of Allergy, Immunology, and Respiratory Medicine, Australia, David H. Broide, Professor of Medicine, University of California San, USA, Leonard B. Bacharier, MD, Vanderbilt University, Doctors' Office Tower, USA, Gurjit K. Khurana Hershey, MD, PhD, Department of Pediatrics, Cincinnati Children’s Hospital, USA, R. Stokes Peebles, Jr., MD, Professor of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA, Stephen R. Durham, National Heart and Lung Institute, Imperial College, Guy Scadding Building, UK and Mübeccel Akdis, MD, PhD, Swiss Institute of Allergy and Asthma Research, University of Zurich, Switzerland
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$369.99
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