Medical Microbiology, 10th Edition

• Focuses on helping the clinician- and scientist-in-training develop a current, complete, and deeper understanding of bacteriology, immunology, virology, mycology, and parasitology, and answer the question: What information do I need to know that will help me understand how to treat an infected patient?
• Contains a new section of eight chapters on Infectious Diseases by Organ System for optimized clinical context.
• Includes clinical photographs and cases to correlate basic science with examples of clinical syndromes.
• Provides quick reference for efficient study with chapter summaries, key information organized in convenient tables, and review questions.
• Offers additional learning resources online, including over 200 self-assessment questions, microscopic images of the microbes, and more.
• An eBook version is included with purchase. The eBook allows you to access all of the text and figures, with the ability to search, customize your content, make notes and highlights, and have content read aloud

Evolve Instructor site with an image and test bank is available to instructors through their Elsevier sales rep or via request at https://evolve.elsevier.com.

Section 1. Introduction
1. Introduction to Medical Microbiology
Historical Perspective
Viruses
Bacteria
Fungi
Parasites
Concept of Infectious Disease
Role of Diagnostic Microbiology Laboratory

2. Human Microbiome in Health and Disease
Human Microbiome Project
Core Microbiome
Evolution of the Microbiome and Normal Flora
Role of the Microbiome in Health and Disease
Diagnostics and Therapeutics
Perspective

3. Infection Control and Preventio
Infection Prevention and Control in the Hospital
Surveillance
Investigating Hospital Acquired Infections
Infection Prevention Program
Personal Protective Equipment
Antimicrobial/Diagnostic Stewardship
Disinfection, Sterilization
Infection Prevention and Control in the Community
Emerging Infectious Diseases
Personal Hygiene
Vaccines
Therapeutics

Section 2. General Principles of Laboratory Diagnosis
4. Traditional Diagnostic Methods
Microscopy
Culture
Identification and Antimicrobial Susceptibility Testing
Serology
Antibody detection
Antigen detection

5. Molecular and Proteomic Method
Microbial Detection
Microbial Identification
Epidemiologic Typing

Section 3. Basic Concepts in the Immune Response
6. Elements of Host Protective Responses
Overview of the immune system as a system
Soluble Activators and Stimulators of Innate and Immune Functions
Cells of the Immune Response

8. Innate Host Responses
Barriers to Infection
Soluble Components of Innate Responses
Cellular Components of Innate Responses
Activation of Innate Cellular Responses
Normal Flora–Associated Responses
Inflammation
Bridge to Antigen-Specific Immune Responses

9. Antigen-Specific Immune Responses
Immunogens, Antigens, and Epitopes
T Cells
Cell-Surface Receptors of T Cells
Development of T Cells
Initiation of T-Cell Responses
Activation of CD4 T Cells and Their Response to Antigen
CD8 T Cells
INNATE T Cells
B Cells and Humoral Immunity
B cells
Immunoglobulin Types and Structures
Immunogenetics
Antibody Response

10. Immune Responses to Infectious Agents
Antibacterial Responses
Antiviral Responses
Specific Immune Responses to Fungi
Specific Immune Responses to Parasites
Other Immune Responses
Immunopathogenesis
Autoimmune Responses
Immunodeficiency11. Antimicrobial Vaccines
Types of Immunizations
Immunization Programs

Section 4. Bacteriology
12. Bacterial Classification, Structure, and Replication
Differences between Eukaryotes and Prokaryotes
Bacterial Classification
Bacterial Structure
Bacterial metabolism
Bacterial Genetics

13. Bacterial Metabolism and Genetics
Bacterial Metabolism
Human Bacterial Metabolism
Bacterial Genes and Expression
Bacterial Genetics

14. Pathogenesis of Bacterial Diseases
Entry into the Human Body
Colonization, Adhesion, and Invasion
Pathogenic Actions of Bacteria
Immunopathogenesis
Mechanisms for Escaping Host Defenses
Summary

15. Role of Bacteria in Disease

16. Laboratory Diagnosis of Bacterial Diseases

17. Antibacterial Agents
Inhibition of Cell Wall Synthesis
Inhibition of Protein Synthesis
Inhibition of Nucleic Acid Synthesis
Other Antibiotics

18. Staphylococcus and Related Gram-Positive Cocci
Physiology and Structure
Pathogenesis and Immunity
Epidemiology
Clinical Diseases
Staphylococcus aureus
Staphylococcus, other species
Laboratory Diagnosis
Treatment, Prevention, and Control

19. Streptococcus and Enterococcus
General Properties
Streptococcus pyogenes
Streptococcus agalactiae
Other β-Hemolytic Streptococci
Viridans Streptococci
Streptococcus pneumoniae
Enterococcus

20. Bacillus
Bacillus anthracis
Bacillus cereus

21. Listeria and Related Gram-Positive Bacteria
Listeria monocytogenes
Erysipelothrix rhusiopathiae
Corynebacterium diphtheriae

22. Mycobacterium and Related Acid-Fast Bacteria
Physiology and Structure of Mycobacteria
Mycobacterium Tuberculosis
Other Slow-Growing Mycobacteria
Rapidly Growing Mycobacteria
Nocardia
Other Weakly Acid-Fast Bacteria

23. Neisseria and Related Genera
Neisseria gonorrhoeae and Neisseria meningitidis
Other Neisseria Species

24. Haemophilus and Related Bacteria
Haemophilus

25. Enterobacteriales
General Properties
Escherichia coli
Salmonella
Shigella
Yersinia
Other Enterobacteriales
Other General Properties

26. Vibrio and Related Bacteria
Vibrio
Aeromonas

27. Pseudomonas and Related Bacteria
Pseudomonas
Burkholderia
Stenotrophomonas maltophilia
Acinetobacter
Moraxella

28. Campylobacter and Helicobacter
Campylobacter
Helicobacter

29. Miscellaneous Gram-Negative Rods
Bartonella
Bordetella
Other Bordetella Species
Brucella
Cardiobacterium
Francisella
Legionella
Streptobacillus

30. Clostridium
Clostridium difficile
Clostridium perfringens
Clostridium tetani
Clostridium botulinum
Other Clostridial Species

31. Non–Spore-Forming Anaerobic Bacteria
Anaerobic Gram-Positive Cocci
Anaerobic Gram-Positive Rods
Anaerobic Gram-Negative Cocci
Anaerobic Gram-Negative Rods

32. Treponema, Borrelia, and Leptospira
Treponema
Borrelia
Leptospira

33. Mycoplasma
Physiology and Structure
Pathogenesis and Immunity
Epidemiology
Clinical Diseases
Laboratory Diagnosis
Treatment, Prevention, and Control

34. Rickettsia, Ehrlichia, and Related Bacteria
Rickettsiaceae
Anaplasmataceae
Coxiellaceae

35. Chlamydia
Physiology and Structure
Chlamydia trachomatis
Chlamydia pneumoniae
Chlamydia psittaci

Section 5. Virology
36. Viral Classification, Structure, and Replication
Classification
Virion Structure
Viral Replication
Viral Genetics
Viral Vectors for Therapy

37. Pathogenesis of Viral Diseases
Basic Steps in Viral Disease
Infection of the Target Tissue
Viral Pathogenesis
Viral Disease
Epidemiology
Control of Viral Spread38. Role of Viruses in Disease
Viral Diseases
Chronic and Potentially Oncogenic Infections
Infections in Immunocompromised Patie

Patrick R. Murray, PhD, F(AAM), F(IDSA), Emeritus Professor University of Maryland School of Medicine Baltimore, Maryland, Ken S. Rosenthal, PhD, Adjunct Professor Infectious Diseases University of Georgia College of Veterinary Medicine; Professor of Immunology Augusta University, University of Georgia Medical Partnership Athens, Georgia; Emeritus Professor Northeastern Ohio Medical University Rootstown, Ohio and Michael A. Pfaller, MD, F(CAP), F(AAM), F(IDSA), Consultant JMI Laboratories North Liberty, Iowa; Professor Emeritus University of Iowa College of Medicine Iowa City, Iowa