cover image - Diagnostic Pathology: Breast, 4th Edition
ISBN: 9780443286810
Copyright: 2026
Publication Date: 04-09-2025
Page Count: 824
Imprint: Elsevier
List Price: $262.99

Diagnostic Pathology: Breast, 4th Edition

by Susan C. Lester, MD, PhD and David G. Hicks, MD

Hardcover

cover image - Diagnostic Pathology: Breast, 4th Edition
ISBN: 9780443286810
Copyright: 2026
Publication Date: 04-09-2025
Page Count: 824
Imprint: Elsevier
List Price: $262.99

$262.99

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This expert volume in the Diagnostic Pathology series is not only an up-to-date, comprehensive diagnostic support tool for surgical pathologists, but also a valuable resource for all health care workers who provide care to patients with breast disease, including radiologists as well as surgical, medical, and radiation oncologists. An excellent point-of-care reference for practitioners at all levels of experience and training, the fourth edition of Diagnostic Pathology: Breast, Fourth Edition provides details on normal breast histology, information to assist in processing breast specimens, and multichapter sections on diagnostic patterns, benign lesions, carcinomas, predictive and prognostic factors, stromal lesions, inflammatory lesions, lymphomas, and hereditary breast disease. Richly illustrated and easy to use, this volume is ideal as a one-stop resource for day-to-day reference or as a reliable training resource.
    • Incorporates the most up-to-date scientific and technical knowledge, providing a comprehensive overview of all key issues relevant to today’s practice
    • Emphasizes the correlation of pathologic lesions with findings on breast imaging and provides guidance on the interpretation of core needle biopsies
    • Contains new overview chapters that lay the groundwork for initial evaluation and assistance with differential diagnosis, as well as new chapters on HER2-low breast carcinoma, immunohistochemical studies for diagnosis, proliferation, and more
    • Provides important updates throughout, covering the evaluation of ESR1, PIK3CA, AKT, and BRCA1 mutations to guide therapy; tumor-infiltrating lymphocytes and PD-L1 for treatment planning; HER2-low assessment to determine eligibility for antibody-drug conjugates; and much more
    • Features new animations and new videos to assist in understanding three-dimensional anatomy, radiologic-pathologic correlation, the processing of breast specimens, and the gross identification of breast lesions
    • Contains more than 3,700 extensively annotated images, including gross pathology photographs, histopathology photomicrographs, a wide range of immunohistochemical stains, fluorescent in situ hybridization, breast-imaging studies, and full-color illustrations
    • Employs consistently templated chapters, bulleted content, key facts, annotated images, and an extensive index for quick, expert reference at the point of care
    • Includes an eBook version that enables you to access all text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud
  • SECTION 1: NORMAL BREAST
    Histology of Normal Breast
    Breast Life Cycle Changes

    SECTION 2: BREAST SPECIMENS
    Breast Specimens Overview
    Core Needle Biopsies
    Excisions and Oncoplastic Surgery
    Margins and Reexcisions
    Mastectomies
    Reduction Mammoplasties
    Lymph Nodes
    Intraoperative Consultation

    SECTION 3: OVERVIEW
    Papillary Lesions
    Spindle Cell Lesions
    Small Acinar Proliferations
    Epithelial/Myoepithelial Lesions
    Vascular and Pseudovascular Lesions
    Lesions with Inflammatory Cells
    Nipple Lesions
    Iatrogenic Changes
    Immunohistochemical Studies

    SECTION 4: BENIGN CHANGES
    Nonproliferative Changes
    Columnar Cell Change, Columnar Cell Hyperplasia, and Flat Epithelial Atypia
    Usual Ductal Hyperplasia
    Sclerosing Adenosis
    Radial Sclerosing Lesion/Radial Scar
    Papilloma, Large Duct and Small Duct
    Nipple Adenoma
    Mucocele-Like Lesions
    Collagenous Spherulosis
    Juvenile Papillomatosis
    Gynecomastia in Men and Gynecomastia-Like Changes in Women
    Hamartoma (Fibroadenolipoma)
    Syringomatous Tumor of the Nipple
    Adenomyoepithelioma
    Cystic Hypersecretory Lesions
    Microglandular Adenosis
    Atypical Ductal Hyperplasia
    Atypical Lobular Hyperplasia

    SECTION 5: CARCINOMAS
    Risk Factors for Developing Carcinoma
    Risk Factors for Developing Breast Carcinoma
    Epidemiology: Lesions Conferring Increased Risk of Breast Carcinoma
    Carcinoma In Situ
    Lobular Carcinoma In Situ
    Ductal Carcinoma In Situ
    Ductal Carcinoma In Situ, Paget Disease
    Special Papillary Carcinomas
    Encapsulated Papillary Carcinoma
    Solid Papillary Carcinoma
    INVASIVE CARCINOMA
    Invasive Carcinoma: Histologic and Molecular Classifications
    Male Breast Carcinoma
    Histologic Types
    Invasive Breast Carcinoma of No Special Type
    Microinvasive Carcinoma
    Invasive Lobular Carcinoma
    Invasive Tubular Carcinoma and Invasive Cribriform Carcinoma
    Invasive Mucinous (Colloid) Carcinoma
    Invasive Papillary Carcinoma
    Invasive Micropapillary Carcinoma
    Invasive Apocrine Carcinoma
    Invasive Neuroendocrine Carcinoma
    Invasive Carcinoma with Osteoclast-Like Giant Cells
    Metaplastic Carcinoma
    Adenoid Cystic Carcinoma
    Secretory Carcinoma
    Biologic Types
    Luminal Carcinoma (ER Positive/HER2 Negative)
    HER2-Positive Carcinoma
    HER2-Low Breast Carcinoma
    Triple Negative Breast Carcinomas and Basal-Like Carcinomas

    SECTION 6: PROGNOSTIC AND PREDICTIVE FACTORS
    Overview of Prognostic and Predictive Factors
    AJCC Breast Cancer Staging
    Anatomic Factors
    Histologic Grade
    Size and Multiple Foci
    Lymphovascular Invasion
    Inflammatory Carcinoma
    Locally Advanced Carcinoma
    Lymph Node Metastases
    Response to Neoadjuvant Therapy
    Locally Recurrent Carcinoma
    Carcinoma with Extensive Intraductal Component
    Molecular Factors
    Hormone Receptors (ER/PR/AR)
    HER2
    Proliferation
    DNA Analysis and Gene Copy Number Alterations
    Circulating Tumor Cells, Circulating Tumor DNA, and Next-Generation Sequencing Immunotherapy
    Expression Profiling, mRNA: Overview
    Expression Profiling: Oncotype DX Assay
    Expression Profiling: MammaPrint Assay
    Expression Profiling: Prosigna
    Expression Profiling: EndoPredict
    Expression Profiling: Protein

    SECTION 7: STROMAL LESIONS
    Pseudoangiomatous Stromal Hyperplasia
    Nodular Fasciitis
    Fibromatosis
    Myofibroblastoma
    Lipoma and Angiolipoma
    Fibroadenoma
    Phyllodes Tumor
    Granular Cell Tumor
    Papillary Endothelial Hyperplasia
    Hemangiomas
    Atypical Vascular Lesions: Post Radiation
    Angiosarcoma
    Sarcomas

    SECTION 8: INFLAMMATORY LESIONS
    Lactational Abscess
    Nonlactational Abscess
    Squamous Metaplasia of Lactiferous Ducts
    Fat Necrosis
    Duct Ectasia
    Sarcoidosis
    Amyloid of the Breast
    Lupus Mastitis
    IgG4-Related Sclerosing Mastitis
    Lymphocytic Lobulitis/Mastopathy
    Implant Pathology

    Section 9: Other Types of Malignancies
    Hematopathologic Malignancies
    Metastases to Breast

    SECTION 10: HEREDITARY BREAST DISEASE
    Overview of Hereditary Breast Cancer
    Table of Germline Mutations
    BRCA1
    BRCA2
    Li-Fraumeni Syndrome
  • Susan C. Lester, MD, PhD, Former Chief of Breast Pathology Services, Brigham and Women’s Hospital, Associate Professor, Harvard Medical School, Boston, Massachusetts, USA and David G. Hicks, MD, Professor and Director of IHC-ISH Laboratory and Breast Subspecialty Service, University of Rochester Medical Center, Rochester, New York, USA

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