Addresses timely topics alongside foundational basic science for an in-depth andcomprehensive understanding of the field
Contains thoroughly up-to-date content, including two new chapters: The Immune System: Implications for Anesthetic Management and Emergency Preparedness in Healthcare
Provides new content in key areas such as sustainability, global health equity, the effect of anesthetics on immune function, anesthesia for special populations, coverage of infectious diseases including COVID-19, and occupational exposure and safety
Offers state-of-the-art coverage of anesthetic drugs, guidelines for anesthetic practice and patient safety, new techniques, step-by-step instructions for patient management, the unique needs of pediatric patients, and much more—all highlighted by more than 1,200 full-color illustrations (300 new to this edition) for enhanced visual clarity
Includes 40+ video clips demonstrating patient positioning, ultrasound, echocardiograms, and other imaging, and anesthetic procedures in real time
SECTION I Introduction 1. The Scope of Modern Anesthetic Practice 2. Anesthesia and Global Health Equity 3. Perioperative Medicine 4. Informatics in Perioperative Medicine 5. Quality Improvement in Anesthesia Practice and Patient Safety 6. Human Behavior and Simulation in Anesthesia 7. Ethical Aspects of Anesthesia Care
SECTION II Anesthetic Physiology 8. Consciousness, Memory, and Anesthesia 9. Sleep Medicine 10. Cerebral Physiology and the Effects of Anesthetic Drugs 11. Neuromuscular Physiology and Pharmacology 12. Respiratory Physiology and Pathophysiology 13. Cardiac Physiology 14. Gastrointestinal and Hepatic Physiology, Pathophysiology, and Anesthetic Considerations 15. Renal Anatomy, Physiology, Pharmacology, and Evaluation of Function 16. Basic Principles of Pharmacology 17. Inhaled Anesthetics: Mechanisms of Action 18. Inhaled Anesthetic Uptake, Distribution, Metabolism, and Toxicity 19. Pulmonary Pharmacology of Inhaled Anesthetics 20. Inhaled Anesthetic Delivery Systems 21. Intravenous Anesthetics 22. Opioids 23. Intravenous Drug Delivery Systems 24. Pharmacology of Neuromuscular Blocking Drugs and Antagonists (Reversal Agents) 25. Local Anesthetics 26. Immune Implications of Anesthesia Care and Practice
SECTION III Anesthesia Management 27. Risk of Anesthesia 28. Preoperative Evaluation 29. Anesthetic Implications of Concurrent Diseases 30. Patient Positioning and Associated Risks 31. Neuromuscular Disorders and Other Genetic Disorders 32. Cardiovascular Monitoring 33. Perioperative Echocardiography and Point-of-Care Ultrasound (POCUS) 34. Implantable Cardiac Pulse Generators: Pacemakers and Cardioverter-Defibrillators 35. Neurophysiologic Monitoring 36. Monitoring the Brain’s Response to Anesthesia and Surgery 37. Respiratory Monitoring 38. Renal Pathophysiology and Treatment for Perioperative Ischemia and Nephrotoxic Injury 39. Neuromuscular Monitoring 40. Airway Management in the Adult 41. Spinal, Epidural, and Caudal Anesthesia 42. Peripheral Nerve Blocks and Ultrasound Guidance for Regional Anesthesia 43. Perioperative Fluid and Electrolyte Therapy 44. Perioperative Acid–Base Balance 45. Patient Blood Management: Transfusion Therapy 46. Patient Blood Management: Coagulation
VOLUME 2 SECTION IV Adult Subspecialty Management 47. Management of the Patient with Chronic Pain 48. Palliative Medicine 49. Anesthesia for Thoracic Surgery 50. Anesthesia for Cardiac Surgical Procedures 51. Anesthesia for Correction of Cardiac Arrhythmias 52. Anesthesia for Vascular Surgery 53. Anesthesia for Neurologic Surgery and Neurointerventions 54. Anesthesia for Bariatric Surgery 55. Anesthesia and the Renal and Genitourinary Systems 56. Anesthesia for Abdominal Organ Transplantation 57. Anesthesia for Organ Procurement 58. Anesthesia for Obstetrics 59. Anesthesia for Fetal Surgery and Other Fetal Therapies 60. Anesthesia for Orthopedic Surgery 61. Geriatric Anesthesia 62. Anesthesia for Trauma 63. Prehospital Care for Medical Emergencies and Trauma 64. Biologic, Natural, and Human-Induced Disasters: The Role of the Anesthesiologist 65. Anesthesia for Ophthalmic Surgery 66. Anesthesia for Otolaryngologic and Head–Neck Surgery 67. Anesthesia for Robotic Surgery 68. Ambulatory (Outpatient) Anesthesia 69. Non–Operating Room Anesthesia 70. Clinical Care in Extreme Environments: Physiology at High Altitude and in Space 71. Clinical Care in Extreme Environments: High Pressure, Immersion, Drowning, Hypo-, and Hyperthermia
SECTION V Pediatric Anesthesia 72. Pediatric Anesthesia 73. Anesthesia for Pediatric Cardiac Surgery 74. Regional Anesthesia in Children 75. Pediatric and Neonatal Critical Care
SECTION VI Postoperative Care 76. The Postanesthesia Care Unit 77. Acute Postoperative Pain 78. Perioperative Neurocognitive Disorders
SECTION VII Critical Care Medicine 79. Critical Care Anesthesiology 80. Neurocritical Care 81. Extracorporeal Membrane Oxygenation and Cardiac Devices 82. Cardiopulmonary Resuscitation and Advanced Cardiac Life Support
SECTION VIII Ancillary Responsibilities and Problems 83. Burn Management 84. Occupational Safety, Infection Control, and Substance Use Disorders 85. Emergency Preparedness in Health Care 86. Clinical Research 87. Interpreting the Medical Literature
Michael A. Gropper, MD, PhD, Distinguished Professor and Chair, Department of Anesthesia and Perioperative Care; Professor of Physiology; Investigator, Cardiovascular Research Institute, University of California, San Francisco, CA, USA, Lars I. Eriksson, MD, Professor and Academic Chair, Department of Anaesthesiology and Intensive Care Medicine, Karolinska University Hospital, Solna, Sweden, Lee A. Fleisher, MD, Robert Dunning Drips Professor and Chair of Anesthesiology and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA, Neal H. Cohen, MD, MPH, MS, Vice Dean, Affiliations and Compliance Professor Emeritus, Anesthesia and Perioperative Care and Medicine, UCSF School of Medicine, San Francisco, California, USA, Kate Leslie, MD, Staff Specialist, Head of Anesthesia Research, Royal Melbourne Hospital; Professor, Department of Anesthesiology, Monash University, Melbourne, Australia and Oluwaseun Johnson-Akeju, MD, Anesthetist-in-Chief, Henry Isaiah Dorr Associate Professor of Research and Teaching in Anaesthetics and Anaesthesia, Massachusetts General Hospital, Boston, Massachusetts, USA
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