Humphrey P. Rang, MB BS MA DPhil Hon FBPharmacolS FMedSci FRS, Emeritus Professor of Pharmacology, University College London, London, UK, Maureen M. Dale, MB BCh PhD, Senior Teaching Fellow, Department of Pharmacology, University of Oxford, Oxford, UK, James M. Ritter, DPhil FRCP FBPharmacolS FMedSci, Emeritus Professor of Clinical Pharmacology, King’s College London, and Medical Research Director, Quintiles, London, UK, Rod Flower and Graeme Henderson, BSc PhD FBPharmacolS FSB, Professor of Pharmacology, University of Bristol, Bristol, UK