Hematology, 4th Edition
Featuring hundreds of full-color photomicrographs, Hematology: Clinical Principles and Applications prepares you for a job in the clinical lab by exploring the essential aspects of hematology. It shows how to accurately identify cells, simplifies hemostasis and thrombosis concepts, and covers normal hematopoiesis through diseases of erythroid, myeloid, lymphoid, and megakaryocytic origins. This book also makes it easy to understand complementary testing areas such as flow cytometry, cytogenetics, and molecular diagnostics. Well-known authors Bernadette Rodak, George Fritsma, and Elaine Keohane cover everything from working in a hematology lab to the parts and functions of the cell to laboratory testing of blood cells and body fluid cells.
- Full-color illustrations make it easier to visualize complex concepts and show what you’ll encounter in the lab.
- Learning objectives begin each chapter, and review questions appear at the end.
- Instructions for lab procedures include sources of possible errors along with comments.
- Case studies provide opportunities to apply hematology concepts to real-life scenarios.
- Hematology instruments are described, compared, and contrasted.
- Coverage of hemostasis and thrombosis includes the development and function of platelets, the newest theories of normal coagulation, and clear discussions of platelet abnormalities and disorders of coagulation.
- A bulleted summary of important content appears at the end of every chapter.
- A glossary of key terms makes it easy to find and learn definitions.
- Hematology/hemostasis reference ranges are listed on the inside front and back covers for quick reference.
- Respected editors Bernadette Rodak, George Fritsma, and Elaine Keohane are well known in the hematology/clinical laboratory science world.
- Student resources on the companion Evolve website include the glossary, weblinks, and content updates.
- New content is added on basic cell biology and etiology of leukocyte neoplasias.
- Updated Molecular Diagnostics chapter keeps you current on techniques being used in the lab.
- Simplified hemostasis material ensures that you can understand this complex and important subject.
- Coverage of morphologic alteration of monocytes/macrophages is condensed into a table, as the disorders in this grouping are more of a biochemical nature with minimal hematologic evidence.
Part I: Introduction to Hematology 1. An Overview of Clinical Laboratory Hematology 2. Safety in the Hematology Laboratory 3. Specimen Collection 4. Care and Use of the Microscope 5. Quality Assurance in Hematology and Hemostasis Testing Part II: Hematopoiesis and Blood Cell Physiology 6. Cellular Structure and Function 7. Hematopoiesis 8. Erythrocyte Production and Destruction 9. Energy Metabolism and Membrane Physiology of the Erythrocyte 10. Hemoglobin Metabolism 11. Iron Metabolism 12. Leukocyte Development, Kinetics, and Function 13. Platelet Production, Structure, and Function Part III: Routine Laboratory Evaluation of Blood Cells 14. Routine and Point of Care Testing in Hematology: Manual and Semi-Automated Methods 15. Examination of the Peripheral Blood Film and Correlation with the Complete Blood Count 16. Bone Marrow Collection and Examination 17. Hematologic Body Fluid Examination Part IV: Hematopathology: Erythrocyte Disorders 18. Anemias: Red Blood Cell Morphology and Approach to Diagnosis 19. Disorders of Iron and Heme Metabolism 20. Anemias Caused by Defects of DNA Metabolism 21. Bone Marrow Failure 22. Introduction to Increased Erythrocyte Destruction 23. Intrinsic Defects Leading to Increased Erythrocyte Destruction 24. Extrinsic Defects Leading to Increased Erythrocyte Destruction-- Nonimmune Causes 25. Extrinsic Defects Leading to Increased Erythrocyte Destruction-- Immune Causes 26. Hemoglobinopathies: Structural Hemoglobin Defects 27. Thalassemias: Quantitative Hemoglobin Defects Part V: Leukocyte Disorders 28. Non-Malignant Leukocyte Disorders 29. Introduction to Leukocyte Neoplasms 30. Cytochemistry 31. Cytogenetics 32. Molecular Diagnostics in the Hematology Laboratory 33. Flow Cytometric Analysis of Hematologic Disorders 34. Myeloproliferative Disorders 35. Myelodysplastic Syndromes 36. Acute Leukemias 37. Lymphomas and Chronic Lymphocytic Leukemias Part VI: Hematology in Selected Populations 38. Pediatric and Geriatric Hematology Part VII: Cell Counting Automation 39. Automated Cell Counting Instrumentation Part VIII: Hemostasis and Thrombosis 40. Normal Hemostasis and Coagulation 41. Hemorrhagic Coagulation Disorders 42. Thrombosis Risk Testing 43. Thrombocytopenia and Thrombocytosis 44. Qualitative Disorders of Platelets and Vasculature 45. Laboratory Evaluation of Hemostasis 46. Monitoring Anticoagulant Therapy 47. Coagulation Instrumentation
Bernadette F. Rodak, MS, MLS, Professor, Clinical Laboratory Science Program, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, George A. Fritsma, MS, MLS, Manager, The Fritsma Factor, Your Interactive Hemostasis Resource, Birmingham, AL and Elaine Keohane, PhD, MLS, Professor, Department of Clinical Laboratory Sciences, University of Medicine and Dentistry of New Jersey, School of Health Related Professions, Newark, NJ