John W Baynes, PhD, Carolina Distinguished Professor Emeritus; Department of Pharmacology, Physiology and Neuroscience; University of South Carolina School of Medicine; Columbia, South Carolina; USA and Marek H. Dominiczak, Dr, Hab, Med, FRCPath, Honorary Professor of Clinical Biochemistry and Medical Humanities, University of Glasgow; Consultant Biochemist, NHS Greater Glasgow and Clyde,Glasgow, UK