• NEW! Coverage of new disorders and syndromes expands the span of differential diagnoses to help you effectively evaluate more signs and symptoms.
• NEW! Addition of new and more widely used diagnostic and laboratory tests keeps you up-to-date as lab tests become more specialized and sophisticated.

PART ONE: CLINICAL SIGNS APPROACH TO DIFFERENTIAL DIAGNOSIS

1. Abdominal Distension
2. Abdominal Effusions and Ascites
3. Abdominal Pain, Acute
4. Aggressive Behavior
5. Alopecia
6. Anaphylaxis
7. Anuria and Oliguria
8. Anxiety and Phobias
9. Ascites
10. Ataxia and Incoordination
11. Blindness
12. Bradycardia, Sinus
13. Cachexia and Muscle Wasting
14. Compulsive Behavior Disorders
15. Constipation
16. Coughing
17. Cyanosis
18. Deafness
19. Diarrhea, Acute
20. Diarrhea, Chronic
21. Dyschezia
22. Dysphagia
23. Dyspnea
24. Dysuria
25. Ecchymoses
26. Edema
27. Epistaxis
28. Failure to Grow/Failure to Thrive
29. Fever of Unknown Origin
30. Flatulence
31. Gagging
32. Genital dermatoses – NEW!
33. Halitosis
34. Head Tilt
35. Hematemesis
36. Hematochezia
37. Hematuria
38. Hemoptysis
39. Hemorrhage, Prolonged
40. Horner’s Syndrome
41. Hyperpigmentation (increased melanin in the epidermis) – NEW!
42. Hyperthermia
43. Hypopigmentation (due to melanocyte destruction, dysfunction, or abnormal distribution of melanosomes) – NEW!
44. Hypothermia
45. Icterus (Jaundice)
46. Inappropriate Elimination
47. Incontinence, Fecal
48. Incontinence, Urinary
49. Infertility, Female (Canine)
50. Infertility, Male (Canine)
51. Joint Swelling
52. Lameness
53. Lymphadenopathy (Lymph Node Enlargement)
54. Melena
55. Muscle Wasting
56. Nasal Discharge
57. Nystagmus
58. Obesity
59. Oliguria
60. Pallor
61. Papules and Pustules
62. Paresis and Paralysis
63. Petechiae and Ecchymoses
64. Pollakiuria
65. Polyuria and Polydipsia
66. Pruritus
67. Ptyalism (Excessive Salivation)
68. Regurgitation
69. Reverse Sneezing – NEW!
70. Scaling and Crusting – NEW!
71. Seizure
72. Sneezing and Nasal Discharge
73. Stertor and Stridor
74. Stranguria, Dysuria, and Pollakiuria
75. Stomatitis
76. Stupor and Coma
77. Syncope
78. Tachycardia, Sinus
79. Tenesmus and Dyschezia
80. Tremor
81. Urine, Discolored
82. Urticaria/Angioedema
83. Vision Loss, Sudden
84. Vomiting
85. Weakness
86. Weight Gain
87. Weight Loss

1. Cardiopulmonary Disorders
2. Arrhythmias
3. Aspiration Pneumonia– NEW!
4. Atrioventricular Valve Disease, Chronic (Mitral or Tricuspid Valve)
5. Cardiomegaly
6. Chylothorax – NEW!
7. Congenital Heart Disease
8. Heart Failure
9. Heartworm Disease
10. Hypertension
11. Laryngeal and Pharyngeal Disease
12. Lower Respiratory Tract Disease
13. Mediastinal Disease
14. Myocardial Diseases
15. Murmurs
16. Pericardial Effusion
17. Pleural Effusion
18. Pulmonary Disease
19. Pulmonary Edema
20. Pulmonary Thromboembolism
21. Tachycardia, Sinus

Section II

22. Dermatologic Disorders
23. Allergic Skin Disease
24. Alopecia, Endocrine
25. Erosions and Ulcerations of Skin or Mucous Membranes – NEW!
26. Folliculitis
27. Otitis Externa, Chronic
28. Parasitic Dermatoses
29. Pigmentation
30. Pyoderma

Section III

31. Endocrinologic and Metabolic Disorders
32. Acromegaly
33. Adrenal Tumors
34. Cretinism (Hypothyroidism in Puppies)
35. Diabetes Insipidus
36. Diabetic Ketoacidosis
37. Diabetes Mellitus
38. Gastrinoma (Zollinger-Ellison Syndrome)
39. Glucagonoma
40. Hyperadrenocorticism
41. Hyperglycemia
42. Hypoadrenocorticism
43. Hypoglycemia
44. Hyponatremia/Hyperkalemia
45. Insulinoma
46. Parathyroidism
47. Pheochromocytoma
48. Pituitary Dwarfism
49. Thyroid Disease

Section IV

50. Gastroenterologic Disorders
51. Chronic Constipation, Feline – NEW!
52. Diarrhea
53. Dental and Oral Cavity Diseases
54. Diseases of the Tongue – NEW!
55. Salivary Gland Disease
56. Esophageal Disease
57. Stomach Disorders
58. Small Intestinal Disease
59. Large Intestinal Disease
60. Ileus
61. Malabsorptive Diseases
62. Perianal Disease
63. Protein-Losing Enteropathy
64. Fecal Incontinence

Section V

65. Hematologic Disorders
66. Anemia
67. Coagulopathies, Inherited and Acquired
68. Leukocyte Disorders
69. Platelet Dysfunction
70. Splenitis/Splenomegaly
71. Thrombocytopenia

Section VI

72. Immunologic and Immune-Mediated Disorders
73. Autoimmune Skin Diseases
74. Immune-Mediated Disease
75. Immune System Components
76. Mechanisms of Immunopathologic Injury – NEW!
77. Organ Systems Affected by Autoimmune Disorders in the Dog and Cat -- NEW!
78. Systemic Lupus Erythematosus (SLE)

Section VII

79. Infectious Disease
80. Anaplasmosis, Canine – NEW!
81. Bacterial Infections, Systemic
82. Ehrlichiosis, Canine
83. Influenza, Canine – NEW!
84. Neorickettsiosis, Canine
85. Mycoses, Systemic – NEW!
86. Polysystemic Protozoal Diseases
87. Rocky Mountain Spotted Fever
88. Sepsis and Systemic Inflammatory Response Syndrome (SIRS)
89. Vaccines, Recommended Core vs. Non-Core – NEW!
90. Viruses, Canine
91. Viruses, Feline

Section VIII

92. Joint and Bone Disorders
93. Arthritis