achievements achievements activity activity activity-online activity-online add-circle add-circle add-document add-new-comment add-to-cart add-to-cart add-users add-users airplay alarm alarm-clock alert alert-drug alert-drug alert-outline-circle alert-outline-square alert-outline-square alert-page-not-found alert-page-not-found alert-qsen alert-qsen alert-safety alert-safety alert-solid-circle alert-solid-circle alert-solid-square alert-solid-square alert-tornado alert-tornado alert-triangle alert-triangle alert-unexpected-error alert-unexpected-error alert-unsupported-browser alert-unsupported-browser alerts alerts alignment apple approve-document archive arrow-down arrow-down arrow-left arrow-left arrow-right arrow-right arrow-stat-up arrow-stat-up arrow-up arrow-up article-in-press assessment-activity assessment-activity assignments assignments audio-slides backspace bicycle binocular blueprint blueprint book bookmark bookmarkoff bookmarkoff bookmarkon bookmarkon books box bubble-chart bullseye business-man business-phone calculator calendar calendar-empty calendar-empty calendar-not-available calendar-not-available call-center camera camera-film card-collapse card-collapse card-expand card-expand carrot case-study case-study caution charge-battery check-clipboard checkmark checkmark chevron-down chevron-down chevron-left chevron-left chevron-right chevron-right chevron-up chevron-up circle circle circle-map-view citatonbench clinical-trial clinical-trial clipboard-check clipboard-check clock clockwise clockwise close close close-quotes cloud cloud-download cloud-upload clouds coffee coffee coffee-and-sugar coffee-bean coffee-not-available coffee-not-available colander collapse collapse column-left column-middle column-right columns comb comment compare-saved-versions compass computer computer-mouse confirmation-outline-circle confirmation-outline-circle confirmation-solid-circle confirmation-solid-circle connection contract countries countries-edit country country-edit couple-of-people create-bibliography credit-card crop cup-of-coffee cursor cycle-question cycle-question cycle-square cycle-square database delete delete-document directions discussion discussion doc doc-file document-check document-check document-checked document-checked document-csv document-csv document-new document-new document-not-available document-not-available down down-left down-right download drag drop duplicate-document dvd-player ebook ebook ebook-reading ebook-reading edit edit education-history eject ellipsis ellipsis-open email empowering-knowledge emtree-taxonomy-browser enlarge enlarge epub eraser exam exam exe-file expand expand-2 expand-2 export export export-document export-file export-file export-profile-orcid eye eye-care eye-not-visible eye-not-visible eye-visible eye-visible failed-outline-circle failed-outline-square failed-solid-circle failed-solid-square fast-forward fax feedback-excited feedback-excited feedback-happy feedback-happy feedback-meh feedback-meh feedback-sad feedback-sad female-face file file filter finger-point-up finger-point-up flag flip-tile flip-tile flowchart flowchart folder folder-in folder-out folder-solid folder-solid forbidden fork fountain-pen fully-charged gear gear gif-file globe globe grid group-of-people group-of-researchers hand hand hard-drive heart heart heart-solid heart-solid help help-icon help-outline-circle help-solid-circle high-battery home home-institution hospital hot hot-tea hy-hart idea in-progress in-progress inbox info information information-outline-circle information-outline-square information-solid-circle information-solid-square institution institution-edit institution-ranking institutions institutions-edit interactive-case-insights journal jpg-file jump-to-first jump-to-first jump-to-last jump-to-last key lab-skills lab-skills label laptop layers leaf left lesson lesson line-charts link list loading location lock log-in log-out low-battery male-face man map-location matrix-view measuring-cup medical-cross medium-battery menu menu merge microphone microwave minus mobile-phone mobipocket molecular-models moon move moving-box moving-box-down moving-box-up mp3-file multiple-layers musical-note nav-collapse nav-collapse nav-expand nav-expand navigate navigate-down navigate-left navigate-right navigate-up neuroimagery new-window new-window newspaper no-editing no-smoking non-solus non-solus not-started not-started note note notebook notifications-disabled office-building open-book open-folder open-hand-right open-quotes orange outbox page page paperclip pause pause-hollow pause-hollow pause-solid pause-solid pdf-alternative pdf-file pencil performance performance performance-not-available performance-not-available person phone phone-disabled picture pie-chart pill pin pixel play play-hollow play-hollow play-solid play-solid play-video plus png-file pointing-left-up pointing-right ppt ppt-2 ppt-2 printer-2 publication-set publication-sets radiology rainbow rainbow-2 rar-file rationale rationale record redo redo reduce reduce refresh remove-document repeat replay research-area research-area-edit research-areas research-areas-edit researcher researcher-profile-needs-action researcher-profile-updated retweet rewind right rotate rotate rows ruler ruler ruler-rotate ruler-rotate save-file scale-down scale-up schedule schedule search search-document secondary-result selection-panel-add selection-panel-remove send settings share share-2 shopping-cart shuffle simulation-nursing simulation-nursing skills-checklist skills-checklist skip-back skip-forward smartphone sorting-down sorting-down sorting-up sorting-up sound-high sound-low sound-medium sound-off speaker speaker spinner spinner standard standard star star-solid star-solid statistics stats stethoscope stop stop-gesture stopwatch strawberry study study subject-name-subcategory suitcase sun syllabus syllabus sync tables tablet tag teddy-bear teddy-bear temperature text-file thumbs-down thumbs-up timer timer tornado trash txt undo undo unlink unlock up up-left up-right upload upwards-line-chart usb user user users users vector video-camera view-author-documents virtual-microscope warning warning webcam wheelchair woman wrench writing x-axis xls y-axis zip-file zoom-in zoom-out
lms folder add youtube facebook instagram google-plus link linkedin twitter
cover image - Principles of Medical Biochemistry - Elsevier eBook on VitalSource (Retail Access Card),4th Edition
ISBN: 9780323391870
Publication Date: 11-28-2016
Page Count: 657
Imprint: Elsevier
List Price: $61.99

Principles of Medical Biochemistry - Elsevier eBook on VitalSource (Retail Access Card), 4th Edition

by Gerhard Meisenberg, PhD and William H. Simmons, PhD

Elsevier eBook on VitalSource - Access Card

ISBN: 9780323391870
Publication Date: 11-28-2016
Page Count: 657
Imprint: Elsevier
List Price: $61.99
Important note
Please note
This item has low stock levels and may be back-ordered. We'll let you know if it is back-ordered, and you will not be charged until the item ships.
    • Just the right amount of detail on biochemistry, cell biology, and genetics – in one easy-to-digest textbook.
    • Full-color illustrations and tables throughout help students master challenging concepts more easily.
    • Online case studies serve as a self-assessment and review tool before exams.
    • Glossary of technical terms, both in print and online.
  • Clinical Boxes and Clinical Content demonstrate the integration of basic sciences and clinical applications, helping readers make connections between the two. New clinical examples have been added throughout the text.

  • Part ONE

    PRINCIPLES OF MOLECULAR STRUCTURE AND

    FUNCTION 1

    Chapter 1

    INTRODUCTION TO BIOMOLECULES

    Water Is the Solvent of Life

    Water Contains Hydronium Ions and Hydroxyl Ions

    Ionizable Groups Are Characterized by Their pK Values

    The Blood pH is Tightly Regulated

    Acidosis and Alkalosis Are Common in Clinical Practice

    Bonds Are Formed by Reactions between Functional Groups

    Isomeric Forms Are Common in Biomolecules

    Properties of Biomolecules Are Determined by Their Noncovalent

    Interactions

    Triglycerides Consist of Fatty Acids and Glycerol

    Monosaccharides Are Polyalcohols with a Keto Group or an

    Aldehyde Group

    Monosaccharides Form Ring Structures

    Complex Carbohydrates Are Formed by Glycosidic Bonds

    Polypeptides Are Formed from Amino Acids

    Nucleic Acids Are Formed from Nucleotides

    Most Biomolecules Are Polymers

    Summary

    Chapter 2

    INTRODUCTION TO PROTEIN STRUCTURE

    Amino Acids Are Zwitterions

    Amino Acid Side Chains Form Many Noncovalent

    Interactions

    Peptide Bonds and Disulfide Bonds Form the Primary Structure of

    Proteins

    Proteins Can Fold Themselves into Many Shapes

    a-Helix and ß-Pleated Sheet Are the Most Common Secondary

    Structures in Proteins

    Globular Proteins Have a Hydrophobic Core

    Proteins Lose Their Biological Activities When Their Higher-Order

    Structure Is Destroyed

    The Solubility of Proteins Depends on pH and Salt

    Concentration

    Proteins Absorb Ultraviolet Radiation

    Proteins Can Be Separated by Their Charge or Their Molecular

    Weight

    Abnormal Protein Aggregates Can Cause Disease

    Neurodegenerative Diseases Are Caused by Protein Aggregates

    Protein Misfolding Can Be Contagious

    Summary

    Chapter 3

    OXYGEN TRANSPORTERS: HEMOGLOBIN AND

    MYOGLOBIN

    The Heme Group Is the Oxygen-Binding Site of Hemoglobin and

    Myoglobin

    Myoglobin Is a Tightly Packed Globular Protein

    Red Blood Cells Are Specialized for Oxygen Transport

    The Hemoglobins Are Tetrameric Proteins

    Oxygenated and Deoxygenated Hemoglobin Have Different

    Quaternary Structures

    Oxygen Binding to Hemoglobin Is Cooperative

    2,3-Bisphosphoglycerate Is a Negative Allosteric Effector of

    Oxygen Binding to Hemoglobin

    Fetal Hemoglobin Has a Higher Oxygen-Binding Affinity than

    Does Adult Hemoglobin

    The Bohr Effect Facilitates Oxygen Delivery

    Most Carbon Dioxide Is Transported as Bicarbonate

    Summary 38

    Chapter 4

    ENZYMATIC REACTIONS 39

    The Equilibrium Constant Describes the Equilibrium of the

    Reaction

    The Free Energy Change Is the Driving Force for Chemical

    Reactions

    The Standard Free Energy Change Determines the Equilibrium

    Enzymes Are Both Powerful and Selective

    The Substrate Must Bind to Its Enzyme before the Reaction Can

    Proceed

    Rate Constants Are Useful for Describing Reaction Rates

    Enzymes Decrease the Free Energy of Activation

    Many Enzymatic Reactions Can Be Described by Michaelis-Menten

    Kinetics

    Km and Vmax Can Be Determined Graphically

    Substrate Half-Life Can Be Determined for First-Order but Not

    Zero-Order Reactions

    Kcat/Km Predicts the Enzyme Activity at Low Substrate

    Concentration

    Allosteric Enzymes Do Not Conform to Michaelis-Menten

    Kinetics

    Enzyme Activity Depends on Temperature and pH

    Different Types of Reversible Enzyme Inhibition Can Be

    Distinguished Kinetically

    Enzymes Stabilize the Transition State

    Chymotrypsin Forms a Transient Covalent Bond during

    Catalysis

    Summary

    Chapter 5

    COENZYMES

    Enzymes Are Classified According to Their Reaction Type

    Adenosine Triphosphate Has Two Energy-Rich Bonds

    ATP Is the Phosphate Donor in Phosphorylation Reactions

    ATP Hydrolysis Drives Endergonic Reactions

    Cells Always Try to Maintain a High Energy Charge

    Dehydrogenase Reactions Require Specialized Coenzymes

    Coenzyme A Activates Organic Acids

    S-Adenosyl Methionine Donates Methyl Groups

    Many Enzymes Require a Metal Ion

    Summary

    Part TWO

    GENETIC INFORMATION: DNA, RNA, AND

    PROTEIN SYNTHESIS

    Chapter 6

    DNA, RNA, AND PROTEIN SYNTHESIS

    All Living Organisms Use DNA as Their Genetic Databank

    DNA Contains Four Bases

    DNA Forms a Double Helix

    DNA Can Be Denatured

    DNA Is Supercoiled

    DNA Replication Is Semiconservative

    DNA Is Synthesized by DNA Polymerases

    DNA Polymerases Have Exonuclease Activities

    Unwinding Proteins Present a Single-Stranded Template to the

    DNA Polymerases

    One of the New DNA Strands Is Synthesized Discontinuously

    RNA Plays Key Roles in Gene Expression

    The S Subunit Recognizes Promoters

    DNA Is Faithfully Copied into RNA

    Some RNAs Are Chemically Modified after Transcription

    The Genetic Code Defines the Structural Relationship between mRNA and Polypeptide

    Transfer RNA Is the Adapter Molecule in Protein Synthesis

    Amino Acids Are Activated by an Ester Bond with the 3' Terminus

    of the tRNA

    Many Transfer RNAs Recognize More than One Codon

    Ribosomes Are the Workbenches for Protein Synthesis

    The Initiation Complex Brings Together Ribosome, Messenger

    RNA, and Initiator tRNA

    Polypeptides Grow Stepwise from the Amino Terminus to the

    Carboxyl Terminus

    Protein Synthesis Is Energetically Expensive

    Gene Expression Is Tightly Regulated

    A Repressor Protein Regulates Transcription of the lac Operon

    in E. coli

    Anabolic Operons Are Repressed by the End Product of the

    Pathway

    Glucose Regulates the Transcription of Many Catabolic

    Operons

    Transcriptional Regulation Depends on DNA-Binding

  • Gerhard Meisenberg, PhD, Course Director Medical Biochemistry, Ross University, Dominica, West Indies and William H. Simmons, PhD, Department of Molecular Pharmacology and Therapeutics, Loyola University School of Medicine, Maywood, Illinois
Important note
Please note
This item has low stock levels and may be back-ordered. We'll let you know if it is back-ordered, and you will not be charged until the item ships.