Richard Mitchell, MD, PhD, Lawrence J. Henderson Professor of Pathology and Health Sciences and Technology, Department of Pathology, Harvard Medical School, Staff Pathologist, Brigham and Women's Hospital, Boston, Massachusetts, Vinay Kumar, MBBS, MD, FRCPath, Alice Hogge and Arthur A. Baer Distinguished Service Professor of Pathology, Biologic Sciences Division and the Pritzker Medical School, The University of Chicago, Chicago, Illinois, USA, Nelson Fausto, MD, Professor and Chair, Department of Pathology, University of Washington, Seattle, Washington, Abul K. Abbas, MBBS, Distinguished Professor and Chair, Department of Pathology, University of California San Francisco, San Francisco, California Emeritus and Jon C. Aster, MD, PhD, Professor, Department of Pathology, Harvard Medical School; Brigham and Women's Hospital, Boston, Massachusetts