Lehne's Pharmacotherapeutics for Advanced Practice Nurses and Physician Assistants, 2nd Edition

• NEW! Genetic and Genomic Considerations chapter addresses our growing understanding of the importance of genetics and genomics in pharmacotherapeutic management of disease.
• NEW! Immunomodulators chapter covers the growing role of this innovative therapy in cancer treatment.
• NEW! Increased emphasis on the needs of prescribers includes new Key Prescribing Considerations specifically tailored for advanced practice nurses (APNs) and Physician Assistants (PAs), revised introductory disease content, and refocused illustrations.
• NEW! Expanded delineation of acute care drugs now extends to the cardiac, neurologic, hypertension, and male and female reproductive chapters.
• NEW! Significantly revised content on laboratory drug monitoring has been refocused on the needs of APNs and PAs
• NEW! Updated content on drug legislation, opioid addiction, and legalized marijuana addresses these key areas of change for prescribers.
• NEW! Illustrations, tables, and boxes have been substituted for text to highlight treatment guidelines (including decision-making algorithms) and drug mechanisms of action.
• NEW! Improved legibility includes the elimination of "small type" and a more user-friendly graphic design.
• NEW! Case Studies in the Evolve Discussion Board have been expanded and now include one new case study per unit — perfect for use in classroom or online discussions to help students develop drug decision-making skills.
• Introductory chapters tailored to the specific needs of prescribers cover topics such as prescriptive authority, rational drug selection and prescription writing, and promoting positive outcomes of drug therapy.
• Carefully focused pharmacotherapeutic content reflects the drugs most commonly seen and used by prescribers, with emphasis not on the first drug discovered or developed in each class but on the agents most often used today. Primary care drugs are addressed first in each chapter as appropriate, followed by acute care drugs.
• UNIQUE! Prescriber-focused pedagogical aids further reinforce the most important information for prescribers.
• Integrated coverage of Canadian trade names appears throughout the text and is highlighted with a familiar maple-leaf icon.
• Integrated coverage of interprofessional collaboration addresses the growing global interest in interprofessional collaboration and incorporates opportunities for interprofessional collaborative practice throughout.

• NEW! Genetic and Genomic Considerations chapter addresses our growing understanding of the importance of genetics and genomics in pharmacotherapeutic management of disease.
• NEW! Immunomodulators chapter covers the growing role of this innovative therapy in cancer treatment.
• NEW! Increased emphasis on the needs of prescribers includes new Key Prescribing Considerations specifically tailored for advanced practice nurses (APNs) and Physician Assistants (PAs), revised introductory disease content, and refocused illustrations.
• NEW! Expanded delineation of acute care drugs now extends to the cardiac, neurologic, hypertension, and male and female reproductive chapters.
• NEW! Significantly revised content on laboratory drug monitoring has been refocused on the needs of APNs and PAs
• NEW! Updated content on drug legislation, opioid addiction, and legalized marijuana addresses these key areas of change for prescribers.
• NEW! Illustrations, tables, and boxes have been substituted for text to highlight treatment guidelines (including decision-making algorithms) and drug mechanisms of action.
• NEW! Improved legibility includes the elimination of "small type" and a more user-friendly graphic design.
• NEW! Updated content covers the areas of drug legislation, opioid addiction, marijuana.

UNIT I: INTRODUCTION 1. Prescriptive Authority 2. Rational Drug Selection and Prescription Writing 3. Promoting Positive Outcomes of Drug Therapy

UNIT II: BASIC PRINCIPLES OF PHARMACOLOGY 4. Pharmacokinetics, Pharmacodynamics, and Drug Interactions 5. Adverse Drug Reactions and Medication Errors 6. Individual Variation in Drug Responses 7. Genetic and Genomic Considerations in Pharmacotherapeutics NEW!

UNIT III: DRUG THERAPY ACROSS THE LIFE SPAN 8. Drug Therapy During Pregnancy and Breast-Feeding 9. Drug Therapy in Pediatric Patients 10. Drug Therapy in Geriatric Patients

UNIT IV: PERIPHERAL NERVOUS SYSTEM DRUGS 11. Basic Principles of Neuropharmacology 12. Physiology of the Peripheral Nervous System 13. Muscarinic Agonists 14. Muscarinic Antagonists NEW! 15. Adrenergic Agonists 16. Adrenergic Antagonists 17. Indirect-Acting Antiadrenergic Agents

UNIT V: CENTRAL NERVOUS SYSTEM DRUGS 18. Introduction to Central Nervous System Pharmacology 19. Drugs for Parkinson Disease 20. Drugs for Alzheimer Disease 21. Drugs for Seizure Disorders 22. Drugs for Muscle Spasm and Spasticity

UNIT VI: DRUGS FOR PAIN 23. Local Anesthetics 24. Opioid Analgesics, Opioid Antagonists, and Nonopioid Centrally Acting Analgesics 25. Drugs for Headache

UNIT VII: PSYCHOTHERAPEUTIC DRUGS 26. Antipsychotic Agents and Their Use in Schizophrenia 27. Antidepressants 28. Drugs for Bipolar Disorder 29. Sedative-Hypnotic Drugs 30. Management of Anxiety Disorders 31. Central Nervous System Stimulants and Attention-Deficit/Hyperactivity Disorder

UNIT VIII: SUBSTANCE USE DISORDERS 32. Substance Use Disorders I: Basic Considerations 33. Substance Use Disorders II: Alcohol 34. Substance Use Disorders III: Nicotine and Smoking 35. Substance Use Disorders IV: Major Drugs of Abuse Other Than Alcohol and Nicotine

UNIT IX: DRUGS THAT AFFECT THE HEART, BLOOD VESSELS, BLOOD, AND BLOOD VOLUME36. Review of Hemodynamics 37. Diuretics 38. Drugs Acting on the Renin-Angiotensin-Aldosterone System 39. Calcium Channel Blockers 40. Vasodilators 41. Drugs for Hypertension 42. Drugs for Heart Failure 43. Antidysrhythmic Drugs 44. Prophylaxis of Atherosclerotic Cardiovascular Disease: Drugs That Help Normalize Cholesterol and Triglyceride Levels 45. Drugs for Angina Pectoris 46. Anticoagulant, Antiplatelet, and Thrombolytic Drugs 47. Drugs for Deficiency Anemias

UNIT X: DRUGS FOR ENDOCRINE DISORDERS 48. Drugs for Diabetes Mellitus 49. Drugs for Thyroid Disorders

UNIT XI: WOMEN'S HEALTH 50. Estrogens and Progestins: Basic Pharmacology and Noncontraceptive Applications 51. Birth Control

UNIT XII: MEN'S HEALTH 52. Androgens 53. Drugs for Erectile Dysfunction and Benign Prostatic Hyperplasia

UNIT XIII: ANTI-INFLAMMATORY, ANTIALLERGIC, AND IMMUNOLOGIC DRUGS 54. Review of the Immune System 55. Childhood Immunization 56. Antihistamines 57. Cyclooxygenase Inhibitors: Nonsteroidal Anti-inflammatory Drugs and Acetaminophen 58. Glucocorticoids in Nonendocrine Disorders

UNIT XIV: DRUGS FOR BONE AND JOINT DISORDERS 59. Drug Therapy of Rheumatoid Arthritis 60. Drug Therapy of Gout 61. Drugs Affecting Calcium Levels and Bone Mineralization

UNIT XV: RESPIRATORY TRACT DRUGS 62. Drugs for Asthma and Chronic Obstructive Pulmonary Disease 63. Drugs for Allergic Rhinitis, Cough, and Colds

UNIT XVI: GASTROINTESTINAL DRUGS 64. Drugs for Peptic Ulcer Disease 65. Laxatives 66. Other Gastrointestinal Drugs

UNIT XVII: NUTRITION AND COMPLIMENTARY THERAPIES 67. Vitamins 68. Drugs for Weight Loss 69. Complementary and Alternative Therapies

UNIT XIII: THERAPY OF INFECTIOUS AND PARASITIC DISEASES 70. Basic Principles of Antimicrobial Therapy 71. Drugs That Weaken the Bacterial Cell Wall I: Penicillins 72. Drugs That Weaken the Bacterial Cell Wall II: Other Drugs 73. Bacteriostatic Inhibitors of Protein Synthesis 74. Aminoglycosides: Bactericidal Inhibitors of Protein Synthesis 75. Sulfonamides and Trimethoprim 76. Drug Therapy of Urinary Tract Infections 77. Drugs Therapy for Tuberculosis 78. Miscellaneous Antibacterial Drugs 79. Antifungal Agents 80. Antiviral Agents I: Drugs for Non-HIV Viral Infections 81. Antiviral Agents II: Drugs for HIV Infection and Related Opportunistic Infections 82. Drug Therapy of Sexually Transmitted Diseases 83. Anthelmintics, Antiprotozoal Drugs, and Ectoparasiticides

UNIT XIX: CANCER THERAPY 84. Introduction to Immunomodulators NEW! 85. Supportive Care of Patients Receiving Anticancer Drugs 86. Drugs for Cancer Pain

UNIT XX: Drugs for Eyes, Ears, and Skin 87. Drugs for the Eye 88. Drugs for the Skin 89. Drugs for the Ear

UNIT XXI: DRUG THERAPY IN ACUTE CARE 90. Agents Affecting the Volume and Ion Content of Body Fluids 91. Management of ST-Elevation Myocardial Infarction 92. Additional Acute Care Drugs

APPENDIX: Canadian Drug Information

Index