Cellular Physiology and Neurophysiology, 3rd Edition
Paperback
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- Helps you easily master the material in a systems-based curriculum with learning objectives, Clinical Concept boxes, highlighted key words and concepts, chapter summaries, self-study questions, and a comprehensive exam.
- Focuses on clinical implications with frequent examples from systems physiology, pharmacology, and pathophysiology.
- Provides a solid depiction of transport processes―an integral topic often treated superficially in other cell biology texts.
- Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Complete the Mosby Physiology Series! Systems-based and portable, these titles are ideal for integrated programs.
- White, Harrison, & Mehlmann: Endocrine and Reproductive Physiology
- Johnson: Gastrointestinal Physiology
- Koeppen & Stanton: Renal Physiology
- Cloutier: Respiratory Physiology
- Pappano & Weir: Cardiovascular Physiology
- Hudnall: Hematology: A Pathophysiologic Approach
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SECTION I, Fundamental Physicochemical Concepts
CHAPTER 1, INTRODUCTION: HOMEOSTASIS AND CELLULAR PHYSIOLOGY
Homeostasis Enables the Body to Survive in Diverse Environments
The Body Is an Ensemble of Functionally and Spatially Distinct Compartments
Transport Processes Are Essential to Physiological Function
Cellular Physiology Focuses on Membrane-Mediated Processes and on Muscle Function
Summary
Key Words and Concepts
CHAPTER 2, DIFFUSION AND PERMEABILITY
Diffusion Is the Migration of Molecules down a Concentration Gradient
Fick’s First Law of Diffusion Summarizes our Intuitive Understanding of Diffusion
Essential Aspects of Diffusion Are Revealed by Quantitative Examination of Random, Microscopic Movements of Molecules
Fick’s First Law Can Be Used to Describe Diffusion across a Membrane Barrier
Summary
Key Words and Concepts
Study Problems
CHAPTER 3, OSMOTIC PRESSURE AND WATER MOVEMENT
Osmosis Is the Transport of Solvent Driven by a Difference in Solute Concentration Across a Membrane That Is Impermeable to Solute
Water Transport during Osmosis Leads to Changes in Volume
Osmotic Pressure Drives the Net Transport of Water during Osmosis
Osmotic Pressure and Hydrostatic Pressure Are Functionally Equivalent in Their Ability to Drive Water Movement Through a Membrane
Only Impermeant Solutes Can Have Permanent Osmotic Effects
Summary
Key Words and Concepts
Study Problems
CHAPTER 4, ELECTRICAL CONSEQUENCES OF IONIC GRADIENTS
Ions Are Typically Present at Different Concentrations on Opposite Sides of a Biomembrane
Selective Ionic Permeability Through Membranes Has Electrical Consequences: The Nernst Equation
The Stable Resting Membrane Potential in a Living Cell Is Established by Balancing Multiple Ionic Fluxes
The Cell Can Change Its Membrane Potential by Selectively Changing Membrane Permeability to Certain Ions
The Donnan Effect Is an Osmotic Threat to Living Cells
Summary
Key Words and Concepts
Study Problems
SECTION II, Ion Channels and Excitable Membranes
CHAPTER 5, ION CHANNELS
Ion Channels Are Critical Determinants of the Electrical Behavior of Membranes
Distinct Types of Ion Channels Have Several Common Properties
Ion Channels Share Structural Similarities and Can Be Grouped into Gene Families
Summary
Key Words and Concepts
Study Problems
CHAPTER 6, PASSIVE ELECTRICAL PROPERTIES OF MEMBRANES
The Time Course and Spread of Membrane Potential Changes Are Predicted by the Passive Electrical Properties of the Membrane
The Equivalent Circuit of a Membrane Has a Resistor in Parallel with a Capacitor
Passive Membrane Properties Produce Linear Current-Voltage Relationships
Membrane Capacitance Affects the Time Course of Voltage Changes
Membrane and Axoplasmic Resistances Affect the Passive Spread of Subthreshold Electrical Signals
Summary
Key Words and Concepts
Study Problems
CHAPTER 7, GENERATION AND PROPAGATION OF THE ACTION POTENTIAL
The Action Potential Is a Rapid and Transient Depolarization of the Membrane Potential in Electrically Excitable Cells
Ion Channel Function Is Studied with a Voltage Clamp
Individual Ion Channels Have Two Conductance Levels
Na＋ Channels Inactivate during Maintained Depolarization
Action Potentials Are Generated by Voltage-Gated Na＋ and K＋ Channels
Action Potential Propagation Occurs as a Result of Local Circuit Currents
Summary
Key Words and Concepts
Study Problems
CHAPTER 8, ION CHANNEL DIVERSITY
Various Types of Ion Channels Help to Regulate Cellular Processes
Voltage-Gated Ca2＋ Channels Contribute to Electrical Activity and Mediate Ca2＋ Entry into Cells
Many Members of the Transient Receptor Potential Superfamily of Channels Mediate Ca2＋ Entry
K＋-Selective Channels Are the Most Diverse Type of Channel
Ion Channel Activity Can Be Regulated by Second-Messenger Pathways
Summary
Key Words and Concepts
Study Problems
SECTION III, Solute Transport
CHAPTER 9, ELECTROCHEMICAL POTENTIAL ENERGY AND TRANSPORT PROCESSES
Electrochemical Potential Energy Drives All Transport Processes
Summary
Key Words and Concepts
Study Problems
CHAPTER 10, PASSIVE SOLUTE TRANSPORT
Diffusion across Biological Membranes Is Limited by Lipid Solubility
Channel, Carrier, and Pump Proteins Mediate Transport across Biological Membranes
Carriers Are Integral Membrane Proteins That Open to Only One Side of the Membrane at a Time
Coupling the Transport of One Solute to the "Downhill" Transport of Another Solute Enables Carriers to Move the Cotransported or Countertransported Solute "Uphill" against an Electrochemical Gradient
Net Transport of Some Solutes across Epithelia Is Effected by Coupling Two Transport Processes in Series
Na＋ Is Exchanged for Solutes Such as Ca2＋ and H＋ by Countertransport Mechanisms
Multiple Transport Systems Can Be Functionally Coupled
Summary
Key Words and Concepts
Study Problems
CHAPTER 11, ACTIVE TRANSPORT
Primary Active Transport Converts the Chemical Energy from ATP into Electrochemical Potential Energy Stored in Solute Gradients
The Plasma Membrane Na＋ Pump (Na＋, K＋-ATPase) Maintains the Low Na＋ and High K＋ Concentrations in the Cytosol
Intracellular Ca2＋ Signaling Is Universal and Is Closely Tied to Ca2＋ Homeostasis
Several Other Plasma Membrane Transport ATPases Are Physiologically Important
Net Transport across Epithelial Cells Depends on the Coupling of Apical and Basolateral Membrane Transport Systems
Summary
Key Words and Concepts
Study Problems
SECTION IV, Physiology of Synaptic Transmission