Firestein & Kelley’s Textbook of Rheumatology, 2-Volume Set, 11th Edition

VOLUME I

Part 1: Structure and Function of Bone, Joints, and Connective Tissue

1. Biology of the Normal Joint, 1 Carla R. Scanzello and Steven R. Goldring

2. Synovium, 20 Douglas J. Veale and Gary S. Firestein

3. Cartilage and Chondrocytes, 34 Ali Mobasheri, Mary B. Goldring, and Richard F. Loeser

4. Biology, Physiology, and Morphology of Bone, 60 Aline Bozec, Anika Grüneboom, and Georg Schett

5. Muscle: Anatomy, Physiology, and Biochemistry, 67 Mark S. Miller, Edward P. Debold, and Michael J. Toth

6. Biomechanics, 80 Kenton R. Kaufman and KaiNan An

7. Regenerative Medicine and Tissue Engineering, 92 Frank P. Luyten, Cosimo De Bari, and Francesco Dell’Accio

8. Proteinases and Matrix Degradation, 109 Yoshifumi Itoh

Part 2: Cells Involved in Autoimmune Diseases and Inflammation

9. Dendritic Cells, 132 Mansi Saxena, Nicolas Vabret, Luciana Ribeiro Muniz, and Nina Bhardwaj

10. Mononuclear Phagocytes, 149 Deborah R. Winter, Anna Montgomery, and Harris Perlman

11. Neutrophils, 161 Binita Shah, Nathalie Burg, and Michael H. Pillinger

12. T Lymphocytes, 182 Ralph C. Budd

13. B Cells, 199 Yong-Rui Zou, Christine Grimaldi, and Betty Diamond

14. Fibroblasts and Fibroblast-like Synoviocytes, 222 Christopher D. Buckley and Andrew Filer

15. Mast Cells, 241 Peter A. Nigrovic

16. Innate Lymphoid Cells and Natural Killer Cells, 254 Michael A. Paley and Wayne M. Yokoyama

17. Platelets and Megakaryocytes, 262 Eric Boilard and Peter A. Nigrovic

Part 3: Effector Mechanisms in Autoimmunity and Inflammation

18. Principles of Signaling, 273 Abel Suarez-Fueyo, Vaishali R. Moulton, and George C. Tsokos

19. The Immunologic Repercussions of Cell Death, 286 Helen M. Beere and Douglas R. Green

20. Innate Immunity, 306 Gregoire Lauvau and Steven A. Porcelli

21. Adaptive Immunity, 320 Martha S. Jordan and Gary A. Koretzky

22. Autoimmunity and Tolerance, 337 Dwight H. Kono and Argyrios N. Theofilopoulos

23. The Microbiome in Health and Disease, 355 Rob Knight

24. Metabolic Regulation of Immunity, 368 Ruoning Wang, Tingting Wang, and Stephen Tait

25. Genetics of Rheumatic Diseases, 378 Stephen Eyre and Anne Barton

26. Epigenetics of Rheumatic Diseases, 393 Amr H. Sawalha and Matlock A. Jeffries

27. Complement System, 409 V. Michael Holers and Leendert A. Trouw

28. Prostaglandins, Leukotrienes, and Related Compounds, 420 Robert B. Zurier

29. Chemokines and Cellular Recruitment, 437 Gerard Graham

30. Angiogenesis, 445 Ursula Fearon, Zoltán Szekanecz, and Douglas J. Veale

31. Cytokines, 455 Iain B. McInnes

32. Experimental Models for Rheumatoid Arthritis, 467 Rikard Holmdahl

33. Neuronal Regulation of Pain and Inflammation, 480 Camilla I. Svensson and Linda S. Sorkin

Part 4: Broad Issues in the Approach to Rheumatic Disease

34. Clinical Research Methods in Rheumatic Disease, 495 Jeffrey R. Curtis, Yvonne M. Golightly, and Kenneth G. Saag

35. Economic Impact of Arthritis and Rheumatic Conditions, 510 Louise B. Murphy

36. Assessment of Health Outcomes, 522 Dorcas E. Beaton, Maarten Boers, Peter Tugwell, and Lara Maxwell

37. Biomarkers in Rheumatology, 536 Michael J. Townsend, Saloumeh K. Fischer, and Andrew C. Chan

38. Occupational and Recreational Musculoskeletal Disorders, 551 Richard S. Panush

39. Cardiovascular Risk in Inflammatory Rheumatic Disease, 563 Cynthia S. Crowson, Sherine E. Gabriel, and Anne Grete Semb

40. Cancer Risk in Rheumatic Diseases, 579 Eric L. Matteson

41. Introduction to Physical Medicine and Rehabilitation, 592 Sara J. Cuccurullo, Jaclyn Joki, and Ofure Luke

42. Pregnancy and Rheumatic Diseases, 604 Lisa R. Sammaritano and Bonnie L. Bermas

Part 5: Evaluation of Generalized and Localized Symptoms

43. History and Physical Examination of the Musculoskeletal System, 621 John M. Davis III, Kevin G. Moder, and Gene G. Hunder

44. Ultrasound in Rheumatology, 638 Eugene Y. Kissin, Paul J. DeMarco, and Amy C. Cannella

45. Evaluation of Monoarticular and Polyarticular Arthritis, 663 Ronald F. van Vollenhoven

46. Skin and Rheumatic Diseases, 678 David F. Fiorentino and Victoria P. Werth

47. The Eye and Rheumatic Diseases, 702 James T. Rosenbaum

Part 6: Differential Diagnosis of Regional and Diffuse Musculoskeletal  Pain

48. Neck Pain, 711 Jennifer Kosty, Rani Nasser, Raul A. Vasquez, Cyrus C. Wong, and Joseph S. Cheng

49. Shoulder Pain, 727 Scott David Martin and Thomas S. Thornhill

50. Low Back Pain, 753 Rajiv Dixit

51. Hip and Knee Pain, 776 James I. Huddleston, III, and Stuart Goodman

52. Foot and Ankle Pain, 792 Christopher P. Chiodo, Mark D. Price, and Adam P. Sangeorzan

53. Hand and Wrist Pain, 800 Kenneth W. Donohue, Felicity G. Fishman, and Carrie R. Swigart

54. Temporomandibular Joint Pain, 813 Daniel M. Laskin

55. Fibromyalgia, 825 Leslie J. Crofford

Part 7: Diagnostic Tests and Procedures in Rheumatic Diseases

56. Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology, 841 Hani S. El-Gabalawy and Stacy Tanner

57. Arthrocentesis and Injection of Joints and Soft Tissues, 859 Ahmed S. Zayat, Andrea di Matteo, and Richard J. Wakefield

58. Anti-nuclear Antibodies, 875 Stanford L. Peng and Joseph E. Craft

Gary S. Firestein, MD, Distinguished Professor of Medicine, Senior Associate Vice Chancellor for Health Sciences, Director, Altman Clinical & Translational Research Institute, Ralph C. Budd, MD, Professor of Medicine and Microbiology and Molecular Genetics, Director, Vermont Center for Immunology and Infectious Diseases, University of Vermont College of Medicine Distinguished University Professor, The University of Vermont College of Medicine, Burlington, Vermont, Sherine E Gabriel, MD, MSc, Professor and Dean, Rutgers Robert Wood Johnson Medical School, CEO, Robert Wood Johnson Medical Group, Emeritus Professor, Mayo Clinic, New Brunswick, New Jersey, Iain B McInnes, PhD, FRCP, FRSE, FMedSci, Muirhead Professor of Medicine, Arthritis Research UK Professor of Rheumatology, Director of Institute of Infection,Immunity, and Inflammation, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom, James R. O'Dell, MD, Bruce Professor and Vice Chairman of Internal Medicine, University of Nebraska Medical Center, Chief of Rheumatology, Department of Medicine, Omaha Veterans Affairs, Omaha, Nebraska and Gary Koretzky, MD, Vice Dean at Weill Cornell Medical College, Frank H.T. Rhodes Distinguished Professor of Cardiovascular Biology and Genetics.