Practical Management of Pain, 6th Edition

SECTION 1. GENERAL CONSIDERATIONS
1. History Is a Distillation of Rumor
2. Classification of Acute Pain and Chronic Pain Syndromes
3. Organizing an Inpatient Acute Pain Service
4. Interdisciplinary Pain Management
5. The Healthcare Policy of Pain Management
6. Quality Assessment, Improvement, and Patient Safety in Pain Management
7. Education, Training, and Certification in Pain Medicine

SECTION 2. BASIC CONSIDERATIONS
8. Neurophysiology of Pain. Peripheral, Spinal, Ascending, and Descending Pathways
9. Neurochemistry of Nociception
10. Neuroimaging Techniques
11. Individual Differences in Experience and Treatment of Pain. Race, Ethnicity, and Sex
12. Communication and Clinician Relationships to Improve Care for Patients With Chronic Pain
13. Pharmacogenetics in Pain Management
14. Psychosocial and Psychiatric Aspects of Chronic Pain
15. Comprehensive Approach to Evaluating Patients With Chronic Pain
16. Mechanism-Based Treatment and Precision Medicine
17. Placebo and Nocebo Effects in Clinical Trials and Clinical Practice

SECTION 3. CLINICAL EVALUATION AND ASSESSMENT
18. History and Physical Examination of the Patient With Pain
19. Electromyography and Evoked Potentials
20. Radiologic Assessment of Patient With Spine Pain
21. Biomarkers of Pain. Quantitative Sensory Testing, Conditioned Pain Modulation, Punch Skin Biopsy
22. Psychological and Behavioral Assessment
23. Disability Assessment

SECTION 4. CLINICAL CONDITIONS. EVALUATION AND TREATMENT
24. Chronic Post-surgical Pain Syndromes. Prediction and Preventive Analgesia
25. Evaluation and Pharmacologic Treatment of Postoperative Pain
26. Regional and Multimodal Treatments of Perioperative Pain
27. Evaluation and Treatment of Postoperative Pain in Patients With Opioid Use Disorder
28. Evaluation and Treatment of Acute Pain in Children
29. Low Back Pain Disorders
30. Buttock and Sciatica Pain
31. Facet Pain. Pathogenesis, Diagnosis, and Treatment
32. Neurosurgical Approaches to Pain Management
33. Evaluation and Treatment of Cancer-Related Pain
34. Evaluation and Treatment of Neuropathic Pain Syndromes
35. Evaluation and Treatment of Complex Regional Pain Syndrome
36. Evaluation and Treatment of Pain in Selected Neurologic Disorders
37. Chronic Widespread Pain
38. Headache Management
39. Cervicogenic Headache, Post-meningeal Puncture Headache, and Spontaneous Intracranial Hypotension
40. Orofacial Pain
41. Visceral Pain
42. Pelvic Pain
43. Pediatric Chronic Pain Management
44. Geriatric Pain Management
45. Managing Pain During Pregnancy and Lactation
46. Rheumatologic Conditions
47. Pain Management in Patients With Comorbidities

SECTION 5. PHARMACOLOGIC, PSYCHOLOGIC, AND PHYSICAL MEDICINE TREATMENTS AND ASSOCIATED ISSUES
48. Major Opioids and Chronic Opioid Therapy
49. Minor Analgesics. Non-Opioid and Opioid Formulations
50. The U.S. Opioid Crisis and the Legal and Legislative Implications
51. Evaluation for Opioid Management. Opioid Misuse Assessment Tools and Drug Testing in Pain Management
52. Pain and Addictive Disorders. Challenge and Opportunity
53. Anti-depressants
54. Adjunct Medications for Pain Management
55. Skeletal Muscle Relaxants
56. Cannabinoids for Pain Management
57. Topical Analgesics
58. Psychological Approaches in Pain Management
59. Evidence-Based Rehabilitation Approaches to Acute and Chronic Pain Management
60. Physical Rehabilitation for Patients With Chronic Pain
61. The Integrative Approach to Pain Management
62. Patient Education and Self-Management

SECTION 6. NEURAL BLOCK AND INTERVENTIONAL TECHNIQUES
63. Neurolytic Agents, Neuraxial Neurolysis, and Neurolysis of Sympathetic Axis for Cancer Pain
64. Head and Neck Blocks
65. Interlaminar and Transforaminal Therapeutic Epidural Injections
66. Radiofrequency Treatment
67. Pain Interventions for the Knee, Hip, and Shoulder
68. Myofascial Injections and Fascial Plane Blocks for Perioperative and Chronic Pain Management
69. Minimally Invasive Procedures for Vertebral Compression Fractures
70. Biopsychosocial Pre-screening for Spinal Cord and Peripheral Nerve Stimulation Devices
71. Spinal Cord Stimulation, Peripheral Nerve Stimulation, Restorative Neurostimulation, Deep Brain Stimulation, and Motor Cortex Stimulation
72. Intrathecal Drug Delivery
73. Radiation Safety and Radiographic Contrast Agents
74. Infection and Anticoagulation Considerations in Pain Procedures

SECTION 7. PAIN MANAGEMENT IN SPECIAL SITUATIONS AND SPECIAL TOPICS
75. Pain Management in Primary Care
76. Pain Management in the Emergency Department
77. Management of Pain in Sickle Cell Disease
78. Burn Pain
79. Pain Evaluation and Management in Patients With Limited Ability to Communicate Because of Dementia
80. Disparities in Pain Care. Descriptive Epidemiology-Potential for Primary Prevention
81. Pain Management in the Critically Ill Patient
82. Pain Management at the End of Life and Home Care for the Terminally Ill Patient

SECTION 8. RESEARCH, ETHICS, HEALTHCARE POLICY, AND FUTURE DIRECTIONS IN PAIN MANAGEMENT
83. Clinical Trial Design Methodology and Data Analytic Strategies for Pain Outcome Studies
84. Outcome Domains and Measures in Acute and Chronic Pain Clinical Trials
85. Ethical Issues in Pain Research
86. Treatment Development. Directions and Areas in Need of Investigation

Honorio Benzon, MD, Professor Emeritus of Anesthesiology, Associate Chair for Academic Affairs and Promotions, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA, James P. Rathmell, MD, Leroy D. Vandam Professor of Anaesthesia, Head of the Department of Anaesthesia at Brigham and Women's Hospital, Boston, Massachussetts, USA, Christopher L. Wu, MD, Professor of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA, Dennis C. Turk, PhD, John and Emma Bonica Endowed Chair for Anesthesiology and Pain Research, Department of Anesthesiology and Pain Medicine, UW Medicine, University of Washington, Seattle, Washington, USA, Charles E. Argoff, MD, Professor of Neurology, Director, Comprehensive Pain Management Center, Albany Medical College, Albany, NY, USA, Robert W. Hurley, MD, PhD, Executive Director, Pain Service Line, Professor, Department of Anesthesiology, Translational Neuroscience and Public Health, Director, Pain Outcomes Lab, Co-Director, NIH-HEAL MIRHIQL Center, Wake Forest University of Medicine, Winston-Salem, North Carolina, USA and Andrea L. Chadwick, MD, MSc, FASA, Kasumi Arakawa Professor of Anesthesiology, Pain and Perioperative Medicine, Director, Fibromyalgia and Centralized Pain Exploration Lab, University of Kansas Medical Center, Kansas City, KS, USA