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cover image - Zipes and Jalife’s Cardiac Electrophysiology: From Cell to Bedside,8th Edition
ISBN: 9780323757454
Copyright: 2023
Publication Date: 12-17-2021
Page Count: 1696
Imprint: Elsevier
List Price: $273.99

Zipes and Jalife’s Cardiac Electrophysiology: From Cell to Bedside, 8th Edition

by Jose Jalife, MD, PhD and William Gregory Stevenson, MD

Hardcover

cover image - Zipes and Jalife’s Cardiac Electrophysiology: From Cell to Bedside,8th Edition
ISBN: 9780323757454
Copyright: 2023
Publication Date: 12-17-2021
Page Count: 1696
Imprint: Elsevier
List Price: $273.99
    • Packs each chapter with the latest information necessary for optimal basic research as well as patient care.

    • Covers new technologies such as CRISPR, protein research, improved cardiac imaging, optical mapping, and wearable devices.

    • Contains significant updates in the areas of molecular biology and genetics, iPSCs (induced pluripotent stem cells), embryonic stem cells, precision medicine, antiarrhythmic drug therapy, cardiac mapping with advanced techniques, and ablation technologies including stereotactic radioablation.

    • Includes 47 new chapters covering both basic science and clinical topics.

    • Discusses extensive recent progress in the understanding, diagnosis, and management of arrhythmias, including new clinical insights on atrial fibrillation and stroke prevention, new advances in the understanding of ventricular arrythmias in genetic disease, and advances in implantable devises and infection management.

    • Features 1,600 high-quality photographs, anatomic and radiographic images, electrocardiograms, tables, algorithms, and more., with additional figures, tables, and videos online.

    • Recipient of a 2018 Highly Commended award from the British Medical Association.

    • Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

  • Section 1 STRUCTURAL AND MOLECULAR BASES OF ION CHANNEL FUNCTION

    1. Voltage-gated sodium channels and electrical excitability of the heart

    2. Voltage-gated calcium

    3. Voltage-gated potassium channels

    4. Structural and molecular bases of cardiac inward rectifier potassium channel function

    5. Mammalian calcium pumps in health and disease

    6. Structural and molecular bases of sarcoplasmic reticulum ion channel function

    7. Organellar ion channels and transporters

    8. Molecular organization, gating, and function of connexin-based gap junction channels and hemichannels

    Section 2 BIOPHYSICS OF CARDIAC ION CHANNEL FUNCTION

    9. Structure-function relations of heterotrimetric complexes of sodium channel a and ß subunits

    10. Regulation of cardiac calcium channels

    11. Inhibition of phosphoinositide 3-kinase and acquired long QT syndrome

    12. Structural determinants and biophysical properties of hERG1 channel gating

    13. Molecular regulation of cardiac inward rectifier potassium channels by pharmacologic agents

    14. Cardiac stretch-activated channels and mechano-electric coupling

    15. Biophysical properties of gap junctions

    16. Excitation-contraction coupling

    Section 3 INTERMOLECULAR INTERACTIONS AND CARDIOMYOCYTE ELECTRICAL FUNCTION

    17. Ion channel trafficking in the heart

    18. Microdomain interactions of macromolecular complexes and regulation of the sodium channel nav1.5

    19. Fibroblast growth factor homologous factors modulate cardiac calcium channels

    20. Macromolecular complexes and cardiac potassium channels

    21. Reciprocity of cardiac sodium and potassium channels in the control of excitability and arrhythmias

    22. The intercalated disc: A molecular network that integrates electrical coupling, intercellular adhesion and cell excitability

    23. Function and dysfunction of ion channel membrane trafficking and post translational modification

    24. Feedback mechanisms for cardiac-specific microRNAs and cAMP signaling in electrical remodeling

    Section 4 CELL BIOLOGY OF CARDIAC IMPULSE INITIATION AND PROPAGATION

    25. Stem cell-derived nodal-like cardiomyocytes as a novel pharmacologic tool: Insights from sinoatrial node development and function

    26. Gene therapy and biologic pacing

    27. Intercellular communication and impulse propagation

    28. Mechanisms of normal and dysfunctional sinoatrial nodal excitability and propagation

    29. Cell biology of the specialized cardiac conduction system

    30. Cardiac remodeling and regeneration

    Section 5 MODELS OF CARDIAC EXCITATION

    31. Ionic mechanisms of atrial action potentials

    32. Genetic algorithms to generate dynamical complexity electrophysiological models

    33. Calcium signaling in cardiomyocyte dodels with realistic geometries

    34. Theory of rotors and arrhythmias

    35. Computational approaches for accurate rotor localization in the human atria

    36. Modeling the aging heart

    Section 6 NEURAL CONTROL OF CARDIAC ELECTRICAL ACTIVITY

    37. Innervation of the sinoatrial node

    38. Mechanism for altered autonomic and oxidant regulation of cardiac sodium currents.

    39. Pulmonary vein ganglia and the neural regulation of the heart rate

    40. Neural activity and atrial tachyarrhythmias

    41. Sympathetic innervation and cardiac arrhythmias

    Section 7 ARRHYTHMIA MECHANISMS

    42. The molecular pathophysiology of atrial fibrillation

    43. Myofibroblasts, cytokines, and persistent atrial fibrillation

    44. Role of the autonomic nervous system in atrial fibrillation

    45. Rotors in human atrial fibrillation

    46. Body surface frequency-phase mapping of atrial fibrillation

    47. Panoramic mapping of atrial fibrillation from the body surface

    48. Mechanisms of human ventricular tachycardia and human ventricular fibrillation

    49. Genetics of atrial fibrillation

    Section 8 MOLECULAR GENETICS AND PHARMACOGENOMICS

    50. Mechanisms in heritable sodium channel diseases

    51. Genetic, ionic, and cellular mechanisms underlying the J-wave syndromes

    52. Inheritable potassium channel diseases

    53. Inheritable phenotypes associated with altered intracellular calcium regulation

    Section 9 PHARMACOLOGIC, GENETIC, AND CELL THERAPY OF ION CHANNEL DYSFUNCTION

    54. Pharmacologic bases of antiarrhythmic therapy

    55. Pharmacogenomics of cardiac arrhythmias

    56. Gene therapy to treat cardiac arrhythmias

    57. Highly mature human iPSC-derived cardiomyocytes as models for cardiac electrophysiology and drug testing

    58. Cardiac repair with human induced pluripotent stem cell-derived cardiovascular cells.

    Section 10 DIAGNOSTIC EVALUATION

    59. Assessment of the patient with a cardiac arrhythmia

    60. Electrocardiography of tachyarrhythmias: Differential diagnosis of narrow and wide QRS complex tachycardias

    61. Electroanatomic mapping for arrhythmias

    62. Computed tomography for electrophysiology

    63. Magnetic resonance imaging for electrophysiology

    64. Intracardiac echocardiography for electrophysiology

    65. Exercise-induced arrhythmias

    66. Cardiac monitoring: short- and long-term recording

    67. Head-up tilt table testing

    68. Autonomic regulation and cardiac risk

    69. T-wave alternans

    70. Noninvasive electrocardiographic imaging of human ventricular arrhythmias and Electrophysiological Substrate

    71. Genetic testing

    Section 11 SUPRAVENTRICULAR TACHYARRHYTHIAS: MECHANISMS, CLINICAL FEATURES, AND MANAGEMENT

    72. Sinus node abnormalities

    73. Atrial tachycardia

    74. Atrial tachycardia in adults with congenital heart disease

    75. Typical and atypical atrial flutter: Mapping and ablation

    76. Atrial fibrillation

    77. Preexcitation, atrioventricular reentry, variants

    78. Electrophysiological characteristics of atrioventricular nodal reentrant tachycardia: Implications for the rentrant circuits

    79. Junctional tachycardia

    Section 12 VENTRICULAR TACHYCARRHYTHMIAS: MECHANISMS, CLNICAL FEATURES, AND MANAGEMENT

    80. Premature ventricular complexes

  • Jose Jalife, MD, PhD, Distinguished Senior Investigator, Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.), Madrid, Spain. Emeritus Professor of Internal Medicine and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan. and William Gregory Stevenson, MD, Director, Cardiac Arrhythmia Program, Cardiovascular Division, Brigham and Women's Hospital; Professor of Medicine Harvard Medical School, Boston, MA