Tietz Textbook of Laboratory Medicine, 7th Edition
Choose THE definitive reference for laboratory medicine and clinical pathology! Tietz Textbook of Laboratory Medicine, 7th Edition provides the guidance necessary to select, perform, and evaluate the results of new and established laboratory tests. Comprehensive coverage includes the latest advances in topics such as clinical chemistry, genetic metabolic disorders, molecular diagnostics, hematology and coagulation, clinical microbiology, transfusion medicine, and clinical immunology. From a team of expert contributors led by Nader Rifai, this reference includes access to wide-ranging online resources on Expert Consult — featuring the comprehensive product with fully searchable text, regular content updates, animations, podcasts, over 1300 clinical case studies, more than 2500 multiple-choice questions, lecture series, and an additional 100+ adaptive learning courses.
- Authoritative, current content helps you perform tests in a cost-effective, timely, and efficient manner; provides expertise in managing clinical laboratory needs; and shows how to be responsive to an ever-changing environment.
- Current guidelines help you select, perform, and evaluate the results of new and established laboratory tests.
- Expert, internationally recognized chapter authors present guidelines representing different practices and points of view.
- Analytical criteria focus on the medical usefulness of laboratory procedures.
- Use of standard and international units of measure makes this text appropriate for any user, anywhere in the world.
- Expert Consult provides the entire text as a fully searchable eBook, and includes regular content updates, animations, podcasts, more than 1300 clinical case studies, over 2500 multiple-choice questions, a lecture series, and more.
- NEW! 19 additional chapters highlight various specialties throughout laboratory medicine.
- NEW! Updated, peer-reviewed content provides the most current information possible.
- NEW! The largest-ever compilation of clinical cases in laboratory medicine is included on Expert Consult.
- NEW! Over 100 adaptive learning courses on Expert Consult offer the opportunity for personalized education.
SECTION I: BASICS OF LABORATORY MEDICINE 1. Laboratory Medicine 2. Statistical Methodologies in Laboratory Medicine: Analytical and Clinical Evaluation of Laboratory Tests Medical Laboratory 3. Governance, Risk, and Quality Management in the 4. Specimen Collection and Processing 5. Preanalytical Variation and Pre-Examination Processes 6. Quality Control of the Analytical Examination Process 7. Standardization and Harmonization of Analytical Examination Results 8. Biological Variation and Analytical Performance Specifications 9. Establishment and Use of Reference Intervals 10. Evidence-Based Laboratory Medicine 11. Biobanking 12. Laboratory Support of Pharmaceutical, In Vitro Diagnostics, and Epidemiologic Studies 13. Machine Learning and Big Data in Laboratory Medicine 14. Laboratory Stewardship and Test Utilization 15. Principles of Basic Techniques and Laboratory Safety SECTION II: ANALYTICAL TECHNIQUES 16. Optical Techniques 17. Electrochemistry and Chemical Sensors 18. Electrophoresis 19. Chromatography 20. Mass Spectrometry 21. Sample Preparation for Mass Spectrometry 22. MALDI-TOF Mass Spectrometry Applications in Infectious Diseases 23. Development and Validation of Small Molecule Analytes by Liquid Chromatography-Tandem Mass Spectrometry 24. Proteomics 25. Enzyme and Rate Analysis 26. Immunochemical Techniques 27. Microfabrication and Microfluidics and Their Application in Clinical Diagnostics 28. Cytometry 29. Automation in the Clinical Laboratory 30. Point-of-Care Testing SECTION III: CLINICAL CHEMISTRY-ANALYTES 31. Amino Acids, Peptides, and Proteins 32. Serum Enzymes 33. Tumor Markers 34. Kidney Function Tests 35. Carbohydrates 36. Lipids and Lipoproteins 37. Electrolytes and Blood Gases 38. Hormones 39. Vitamins and Trace Elements 40. Iron Metabolism 41. Porphyrins and the Porphyrias 42. Therapeutic Drugs and Their Management 43. Clinical Toxicology 44.Toxic Elements 45.Body Fluids SECTION IV: CLINICAL CHEMISTRY-PATHOPHYSIOLOGY 46.Nutrition: Laboratory and Clinical Aspects 47.Diabetes Mellitus 48.Cardiac Function 49.Kidney Disease 50.Disorders of Water, Electrolytes, and Acid-Base Metabolism 51.Liver Disease 52.Gastric, Intestinal, and Pancreatic Function 53.Monoamine-Producing Tumors 54.Bone and Mineral Metabolism 55.Pituitary Function and Pathophysiology 56.Adrenal Cortex 57.Thyroid Disorders 58.Reproductive Endocrinology and Related Disorders 59.Pregnancy and Its Disorders SECTIONV:GENETICMETABOLICDISORDERS 60.NewbornScreeningandInbornErrorsofMetabolism 61.Inborn Errors of Metabolism: Disorders of Complex Molecules SECTION VI: MOLECULAR DIAGNOSTICS 62.Principles of Molecular Biology 63.Nucleic Acid Isolation 64.Nucleic Acid Techniques 65.Genomes,Variants,andMassivelyParallelMethods 66.Clinical Genome Sequencing 67.Molecular Microbiology 68.Genetics 69.Solid Tumors 70.Hematopathology 71.Circulating Tumor Cells and Circulating Nucleic Acids in Oncology 72.CirculatingNucleicAcidsforPrenatalDiagnostics 73.Pharmacogenetics SECTION VII: HEMATOLOGY AND COAGULATION 74.Automated Hematology 75.LeukocyteMorphologyinBloodandBoneMarrow 76.Red Blood Cell Morphology and Indices: The Clinical Chemistry Interface 77.Hemoglobin and Hemoglobinopathies 78.Enzymes of the Red Blood Cell 79.Physiology of Hemostasis 80.Platelets and von Willebrand Factor 81.Coagulation, Anticoagulation, and Fibrinolysis SECTION VIII: MICROBIOLOGY 82.Introduction to Infectious Diseases 83.The Role of the Clinical Laboratory in Infection Prevention and Antimicrobial Stewardship 84.Bacteriology 85.Antimicrobial Susceptibility Testing 86.Mycobacteriology 87.Mycology 88.Parasitology 89.Virology SECTION IX: TRANSFUSION MEDICINE 90.Blood Group Systems and Pretransfusion Testing 91.Blood Components, Product Modifications, and Blood Donor Screening 92.Indications for Transfusion: RBCs, Platelets, Plasma,and Cryoprecipitate 93.Transfusion Reactions and Adverse Events Associated With Transfusion SECTION X: CLINICAL IMMUNOLOGY 94.Systemic Autoimmune Disease 95.Transplant, Solid Organ 96.Hematopoietic Cell Transplantation 97.Transplant Compatibility Testing 98.Monoclonal Antibody Therapeutics and Immunogenicity 99.Allergy Testing 100.Primary Immunodeficiencies and Secondary Immunodeficiencies APPENDICES Appendix A: Reference Information for the Clinical Laboratory Appendix B: Answers to Multiple Choice Questions
Nader Rifai, PhD, Professor Department of Pathology Harvard Medical School; The Louis Joseph Gay-Lussac Chair in Laboratory Medicine Boston Children's Hospital; Director of Clinical Chemistry Laboratory Medicine Boston Children's Hospital Boston, Massachusetts