Clinical Biochemistry, 7th Edition

Preface to the sixth edition
Preface to the seventh edition
Acknowledgements

Part 1: Introducing clinical biochemistry
1 The clinical biochemistry laboratory
2 The use of the laboratory
3 Interpretation of results: general
4 Interpretation of results: diagnosis
5 Interpretation of results: monitoring
6 Analytical aspects

Part 2: Core biochemistry
7 Fluid and electrolytes: basic
concepts
8 Water and sodium balance: physiological mechanisms
9 Hyponatraemia: pathophysiology
10 Hyponatraemia: assessment and management
11 Hypernatraemia
12 Hyperkalaemia
13 Hypokalaemia
14 Intravenous fluid therapy
15 Investigation of renal function (1)
16 Investigation of renal function (2)
17 Urinalysis
18 Proteinuria
19 Acute kidney injury
20 Chronic kidney disease
21 Acid–base: concepts and vocabulary
22 Metabolic acid–base disorders
23 Respiratory and mixed acid–base disorders
24 Acid–base disorders: diagnosis and management
25 Proteins and enzymes
26 Immunoglobulins
27 Myocardial infarction
28 Liver function tests
29 Jaundice
30 Liver disease
31 Glucose metabolism and diabetes mellitus
32 Diagnosis and monitoring of diabetes mellitus
33 Diabetic ketoacidosis
34 Hypoglycaemia
35 Calcium regulation and hypocalcaemia
36 Hypercalcaemia
37 Phosphate and magnesium
38 Metabolic bone disease
39 Osteoporosis and fragility fractures

Part 3: Endocrinology
40 Endocrine control
41 Dynamic function tests
42 Pituitary function
43 Growth disorders and acromegaly
44 Thyroid pathophysiology
45 Hypothyroidism
46 Hyperthyroidism
47 Adrenocortical pathophysiology
48 Hypofunction of the adrenal cortex
49 Hyperfunction of the adrenal cortex
50 Gonadal function
51 Subfertility

Part 4: Specialised investigations
52 Nutritional assessment
53 Nutritional support
54 Parenteral nutrition
55 The metabolic response to injury
56 Gastrointestinal disorders
57 Disorders of the pancreas
58 Iron
59 Zinc and copper
60 Therapeutic drug monitoring
61 Toxicology
62 Metal poisoning
63 Alcohol
64 Ascites
65 Pleural fluid
66 Cerebrospinal fluid
67 Identification of body fluids
68 Lipoprotein metabolism
69 Clinical disorders of lipid metabolism
70 Hypertension
71 Cancer and its consequences
72 Tumour markers
73 Multiple endocrine neoplasia
74 Hyperuricaemia
75 Myopathy
76 Fetal monitoring and prenatal diagnosis
77 Pregnancy
78 Antenatal screening
79 Screening the newborn for disease
80 Paediatric biochemistry
81 Inborn errors of metabolism
82 Methods involving antibodies: immunoassay
83 Methods to separate and identify molecules
84 Selected inherited disorders

Case history comments
Index

Michael Murphy, MA MD FRCP FRCPath, Clinical Reader in Biochemical Medicine, University of Dundee, Dundee, UK, Rajeev Srivastava, MS FRCS FRCPath, Consultant Clinical Biochemist, NHS Greater Glasgow & Clyde, Glasgow, UK and Kevin Deans, PhD FRCP FRCPath, Consultant Clinical Biochemist, NHS Grampian, Aberdeen, UK