Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases - Elsevier eBook on VitalSource, 10th Edition

by Martin J. Blaser, MD, Jeffrey I. Cohen, MD and Steven M. Holland, MD

Elsevier eBook on VitalSource

ISBN: 9780323935890

Page Count: 4176

Imprint: Elsevier

List Price: $401.99

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Key Features
- Organizes content both by individual pathogens and by important clinical syndromes, broadening the context to clearly present relevant, complex clinical information.
- Contains multiple new chapters on both SARS-CoV-2 and anti-fungal therapy, as well as new chapters on bacteriophages and related agents, infections following traumatic injuries, communication to the public about infectious diseases, and the effects of climate change on infectious diseases.
- Provides up-to-date coverage of recent advances in the field: an increasing understanding of the agents, immune responses, and the growing armamentarium of diagnostics (such as nucleic acid amplification and next-generation sequencing); new treatments (such as monoclonal antibodies, new antifungals, antivirals, and phage therapy); and emerging preventive measures (such as new vaccines being developed for RSV), and our relationship with the human microbiome.
- Features more than 1,500 high-quality, full-color photographs―with many new to this edition.
- Shares the extensive experience of new editors Drs. Jeffrey I. Cohen and Steven M. Holland, both from Bethesda, MD, as well as a new team of expert associate editors Drs. Yohei Doi, Wendy S. Garrett, Ann R. Falsey, Eleanor Wilson, Kieren Marr, and Edward Mitre—each a leading authority in their field.
- Includes perspectives from hundreds of leading experts from a truly global community, including authors from Australia, Canada, and countries in Europe, Asia, and South America.
- Includes regular updates online for the life of the edition.
Contents

PART I: BASIC PRINCIPLES IN THE DIAGNOSIS AND MANAGEMENT OF INFECTIOUS DISEASES
Section A: Microbial Pathogens
1. A Molecular Perspective of Microbial Pathogenicity
2. The Human Microbiome
3. Prebiotics, Probiotics, and Synbiotics

Section B: Host Defense Mechanisms
4. Innate (General or Nonspecific) Host Defense Mechanisms
5. Adaptive Immunity: Antibodies and Immunodefiencies
6. Cell-Mediated Defense Against Infection
7. Mucosal Immunity
8. Granulocytic Phagocytes
9. Complement and Deficiencies
10. Human Genetics and Infection
11. Nutrition, Immunity, and Infection
12. Evaluation of the Patient with Suspected Immunodeficiency

Section C: Epidemiology of Infectious Disease
13. Principles of Applied Epidemiology for the Practice of Infectious Diseases
14. Emerging and Reemerging Infectious Disease Threats
15. Bioterrorism: An Overview

Section D: Clinical Microbiology
16. The Clinician and the Microbiology Laboratory: Test Ordering, Specimen Collection, and Result Interpretation

Section E: Antiinfective Therapy
17. Principles of Anti-Infective Therapy
18. Molecular Mechanisms of Antibiotic Resistance in Bacteria
19. Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents
20. Penicillins and β-Lactamase Inhibitors
21. Cephalosporins and Cephalosporin/β-Lactamase Inhibitor Combinations
22. Carbapenems, Carbapenem/β-Lactamase Inhibitor Combinations, and Aztreonam
23. Antibiotic Allergy
24. Aminoglycosides
25. Tetracyclines, Tetracycline Derivatives, and Chloramphenicol
26. Rifamycins
27. Metronidazole
28. Macrolides and Clindamycin
29. Glycopeptides (Vancomycin and Teicoplanin) and Lipoglycopeptides (Telavancin, Oritavancin, and Dalbavancin)
30. Streptogramins (Quinupristin-Dalfopristin) and Lipopeptides (Daptomycin)
31. Polymyxins (Polymyxin B and Colistin)
32. Linezolid,Tedizolid, and Other Oxazolidinones
33. Sulfonamides and Trimethoprim; Trimethoprim-Sulfamethoxazole
34. Quinolones
35. Antibiotics in Advanced Development and Other Agents
36. Urinary Tract Agents: Nitrofurantoin, Fosfomycin and Methenamine
37. Topical Antibacterials
38. Antimycobacterial Agents
39. Bacteriophage Therapy, Endolysin Therapy and Antimicrobial Peptide Therapy
40. Antifungal Agents: Polyene Antifungals
41. Antifungal Drugs: Azole
42. Antifungal Drugs: Echinocandins and Other Beta-D-glucan Inhibitors
43. Antifungal Drugs: Flucytosine
44. Antimalarial Drugs
45. Drugs for Protozoal Infections Other Than Malaria
46. Drugs for Helminths
47. Antiviral Agents: General Principles
48. Antiviral Drugs for Influenza and Other Respiratory Virus Infections Except for SARS-CoV-2
49. Antivirals Against Herpesviruses
50. Antiviral Drugs Against Hepatitis Viruses
51. Miscellaneous Antivirals Agents (Interferons, Tecovirimat, Imiquimod, Pocapavir)
52. Immunomodulators
53. Hyperbaric Oxygen
54. Antimicrobial Stewardship
55. Designing and Interpreting Clinical Studies in Infectious Diseases
56. Outpatient Parenteral Antimicrobial Therapy

PART II: MAJOR CLINICAL SYNDROMES
Section A: Fever
57. Temperature Regulation and the Pathogenesis of Fever
58. Fever of Unknown Origin
59. The Acutely Ill Patient with Fever and Rash

Section B: Upper Respiratory Tract Infections
60. The Common Cold
61. Pharyngitis
62. Acute Laryngitis
63. Otitis Externa, Otitis Media, and Mastoiditis
64. Sinusitis
65. Epiglottitis
66. Infections of the Oral Cavity, Neck, and Head

Section C: Pleuropulmonary and Bronchial Infections
67. Acute Bronchitis
68. Acute Exacerbations of Chronic Obstructive Pulmonary Disease
69. Acute Pneumonia
70. Pleural Effusion and Empyema
71. Bacterial Lung Abscess
72. Chronic Pneumonia
73. Cystic Fibrosis

Section D: Urinary Tract Infections
74. Urinary Tract Infections

Section E: Sepsis
75. Sepsis and Septic Shock

Section F: Intraabdominal Infections
76. Peritonitis and Intraperitoneal Abscesses
77. Infections of the Liver and Biliary System (Liver Abscess, Cholangitis, Cholecystitis)
78. Pancreatic Infection
79. Splenic Abscess
80. Appendicitis
81. Diverticulitis and Neutropenic Enterocolitis

Section G: Cardiovascular Infections
82. Endocarditis and Intravascular Infections
83. Prosthetic Valve Endocarditis
84. Infections of Nonvalvular Cardiovascular Devices
85. Prophylaxis of Infective Endocarditis
86. Myocarditis and Pericarditis
87. Mediastinitis

Section H: Central Nervous System Infections
88. Approach to the Patient with Central Nervous System Infection
89. Acute Meningitis
90. Chronic Meningitis
91. Encephalitis
92. Brain Abscess
93. Subdural Empyema, Epidural Abscess, and Suppurative Intracranial Thrombophlebitis
94. Cerebrospinal Fluid Shunt and Drain Infections

Section I: Skin and Soft Tissue Infections
95. Cellulitis, Necrotizing Fasciitis, and Subcutaneous Tissue Infections
96. Myositis and Myonecrosis
97. Lymphadenitis and Lymphangitis

Section J: Gastrointestinal Infections and Food Poisoning
98. Syndromes of Enteric Infection
99. Esophagitis
100. Diarrhea with Little or No Fever
101. Acute Dysentery Syndromes (Diarrhea with Fever)
102. Typhoid Fever, Paratyphoid Fever, and Typhoidal Fevers
103. Foodborne Disease (Food Poisoning)
104. Tropical Sprue and Environmental Enteric Dysfunction

Section K: Bone and Joint Infections
105. Infectious Arthritis of Native Joints
106. Osteomyelitis
107. Orthopaedic Implant-Associated Infections

Section L: Diseases of The Reproductive Organs and Sexually Transmitted Diseases
108. Anogenital Skin and Mucous Membrane Lesions
109. Urethritis
110. Vulvovaginitis and Cervicitis
111. Infections of the Female Pelvis
112. Prostatitis, Epididymitis, and orchitis

Section M: Eye Infections
113. Introduction to Eye Infections
114. Microbial Conjunctivitis
115. Microbial Keratitis
116. Endophthalmitis
117. Infectious Causes of Uveitis
Authors

Martin J. Blaser, MD, Henry Rutgers Chair of the Human Microbiome, Professor of Medicine and Pathology & Laboratory Medicine - RWJMS; Director, Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey, USA, Jeffrey I. Cohen, MD, Bethesda, MD and Steven M. Holland, MD, Bethesda, MD