Contains new sections on global child neurology and environment and brain development and a greatly expanded section on neurogenetics, in addition to new chapters on autoimmune epilepsies, immune-mediated movement disorders, and more.
Offers expanded online content, including additional figures, tables, and text, as well as new personal introductory videos by many chapter authors.
Covers new, emerging, or controversial topics such as COVID-19, teleneurology, environment and brain development, immune-mediated disorders of the nervous system, functional neurological disorders in children, nonverbal learning disorders, and the pharmacological and future genetic treatment of neurodevelopmental disabilities.
Provides authoritative coverage of perinatal acquired and congenital disorders, neurodevelopmental disabilities, extensive sections on pediatric epilepsy and movement disorders, nonepileptiform paroxysmal disorders, and disorders of sleep.
Features nearly 3,000 line drawings, photographs, tables, and boxes that highlight the text, clarify key concepts, and make it easy to find information quickly.
An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date.
PART I: Clinical Evaluation 1. General Aspects of the Patient’s Neurologic History 2. Neurologic Examination of the Older Child 3. Neurologic Examination of Young Children (Ages 1–5 Years) 4. Neurologic Examination of Infants (Ages 0–1 Year) 5. Motor Signs 6. Vision Loss 7. Hearing Impairment 8. Vertigo 9. Taste and Smell 10. Neuropsychological Assessment
PART II: Care of the Child With Neurologic Disorders 11. Counseling Children With Neurologic Disorders and Their Families 12. Pediatric Neurorehabilitation Medicine 13. Pediatric Palliative Care, Pain, and Symptom Management 14. Practical Bioethics in Child Neurology 15. Transitional Care for Children With Neurologic Disorders 16. Practice Guidelines in Pediatric Neurology 17. Measurement of Health Outcomes in Pediatric Neurologic Disorders 18. Computer Resources, Artificial Intelligence, and Telemedicine 19. Education and Training of Child Neurologists and Workforce Issues
PART IV: Global Child Neurology 23. Regional and Global Implications for Children’s Brain Health 24. Implementing Child Neurology Care in Resource-Limited Settings 25. Adaptation and Implementation of Guidelines at the Local Level
PART V: Neonatal Neurology 26. Neonatal Neuro-Intensive Care 27. Provoked Neonatal Seizures and Neonatal Onset Epilepsy 28. Hypoxic-Ischemic Brain Injury in the Term Newborn 29. Cerebrovascular Disorders in the Newborn 30. Neonatal Nervous System Trauma 31. Injury to the Developing Preterm Brain: Intraventricular Hemorrhage and White Matter Injury 32. Perinatal Metabolic Encephalopathies
PART VI: Environment and Brain Development 33. The Neural Exposome and Environmental Neuroscience 34. Adverse Childhood Experiences 35. The Neurological Impact of Prenatal Substance Exposure 36. Environmental Pollutants 37. Malnutrition, Nutrition, and Dietary Toxins 38. Poisoning and Drug-Induced Neurologic Diseases
PART VII: Congenital Structural Defects 39. Introduction to Human Brain Malformations 40. Disorders of Neural Tube Development 41. Disorders of Forebrain Development 42. Disorders of Cerebellar and Brainstem Development 43. Microcephaly and Megalencephaly: Disorders of Brain Size 44. Malformations of Cortical Development 45. Hydrocephalus, Cysts, and Cystic Malformations 46. Congenital Anomalies of the Skull 47. Prenatal Diagnosis of Structural Brain Anomalies
PART VIII: Neurogenetics 48. Neurogenetics in the Genome Era 49. Genetic Counseling in the Genomic Era 50. Chromosomes and Chromosomal Abnormalities 51. Single-Gene Abnormalities 52. Neurocutaneous Disorders 53. Emerging Gene-Based Pathways: Channelopathies (Epilepsy and Beyond) 54. Emerging Gene-Based Pathways: mTORopathies 55. Emerging Gene-Based Pathways: RASopathies 56. Emerging Gene-Based Pathways: Chromatin Remodeling Disorders 57. The Neuronal Ceroid Lipofuscinoses
PART IX: Metabolic Disorders 58. Approach to the Patient With a Metabolic Disorder 59. Aminoacidemias and Organic Acidemias 60. Urea Cycle Disorders 61. Diseases Associated With Primary Abnormalities in Carbohydrate Metabolism 62. Disorders of Glycosylation 63. Lysosomal Storage Diseases 64. Mitochondrial Diseases 65. Peroxisomal Disorders 66. Neurotransmitter-Related Disorders 67. Disorders of Vitamin Metabolism
PART X: Neurodevelopmental Disorders 68. Neurodevelopmental Disabilities: Conceptual Framework 69. Intellectual Developmental Disorder and Global Developmental Delay 70. Regressive and Degenerative Genetic Neurological Disorders 71. Developmental Encephalopathies 72. Developmental Language Disorders 73. Nonverbal Learning Disorders 74. Dyslexia 75. Attention-Deficit/Hyperactivity Disorder 76. Autism Spectrum Disorder 77. Cerebral Palsy 78. Developmental Coordination Disorder 79. Treatment of Neurodevelopmental Disorders 80. Neuropsychopharmacology
PART XI: Epilepsy 81. Overview of Seizures and Epilepsy in Children 82. Principles of Management and Outcome 83. Pathophysiology of Seizures and Epilepsy 84. Epilepsy Genetics 85. Febrile Seizures 86. Generalized Seizures 87. Focal and Multifocal Seizures 88. Myoclonic Seizures 89. Infantile Epileptic Spasms Syndrome 90. Status Epilepticus 91. Electroclinical Syndromes: Neonatal Onset 92. Electroclinical Syndromes: Infantile Onset 93. Electroclinical Syndromes: Childhood Onset 94. Electroclinical Syndromes: Adolescent Onset 95. Focal Structural Epilepsy 96. Acquired Epilepsies: Trauma, Stroke, and Tumors 97. Inherited Metabolic Epilepsies 98. Antiseizure Medication Therapy in Children 99. Epilepsy Surgery in the Pediatric Population 100. Neuromodulation in Epilepsy 101. Ketogenic Diets 102. Behavioral, Cognitive, and Social Implications of Childhood Epilepsy 103. Mortality in Children With Epilepsy
PART XII: Nonepileptiform Paroxysmal Disorders 104. Headache in Children and Adolescents 105. Breath-Holding Spells and Reflex Anoxic Seizures 106. Psychogenic Nonepileptic Seizures and Psychiatric Disorders 107. Functional Neurological Symptom Disorder in Children and Adolescents 108. Syncope and Postural Orthostatic Tachycardia Syndrome 109. Brief Resolved Unexplained Events, Apparent Life-Threatening Events, and Sudden Infant Death Syndrome
PART XIII: Disorders of Sleep 110. Restless Legs Syndrome and Periodic Limb Movement Disorder in Children and Adolescents 111. Nocturnal Paroxysmal Disorders 112. Disorders of Excessive Sleepiness
PART XIV: Disorders of Balance and Movement 113. The Cerebellum and the Hereditary Ataxias 114. Movement Disorders: An Overview 115. Paroxysmal Dyskinesias 116. Movement Disorders of Infancy
Stephen Ashwal, MD, Distinguished Professor of Pediatrics, Former Chief of the Division of Child Neurology and Pediatrics, Loma Linda University School of Medicine, Loma Linda, California, USA and Phillip L. Pearl, MD, Director of Epilepsy and Clinical Neurophysiology, William G. Lennox Chair and Professor of Neurology, Harvard Medical School, Boston, Massachusetts, USA
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