Expertly written and meticulously edited to ensure scientifically accurate, accessible content throughout, Gunderson and Tepper’s Clinical Radiation Oncology, 6th Edition, provides complete, multidisciplinary coverage of this complex and dynamic field. Concise, templated chapters cover the basic biology of oncologic disease processes as well as updated treatment algorithms, the latest clinical guidelines, and state-of-the-art techniques and modalities. User-friendly elements such as summarized key issues, full-color formatting, extensive use of tables and figures, and access to videos online make this reference an ideal resource for every member of the radiation oncology team.
Divides content into three distinct sections for quick access to information: Scientific Foundations, Techniques and Modalities, and Disease Sites. Disease Site chapters include overviews summarizing the most important issues and concluding discussions on controversies and problems
Provides expert guidance on single-modality and combined-modality approaches, as well as outcome data including disease control, survival, and treatment tolerance
Contains a new chapter on artificial intelligence in radiation, as well as up-to-date coverage of advancements in interventional radiology tumor ablation techniques and associated outcomes; updated guidance on using Intraoperative Radiation Therapy (IORT) as a radiation dose escalation tool; and increased coverage of proton therapy
Features more than 1,000 images―detailed anatomy drawings, radiographic images, and more―that provide outstanding visual support for every area of the text
Covers key topics such as brachytherapy, precision radiation therapy, palliative radiotherapy, quality and safety, image-guided radiotherapy (IGRT), and stereotactic radiosurgery
Includes access to videos on intraoperative irradiation, prostate brachytherapy, penile brachytherapy, and ocular melanoma
An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud
SECTION 1 Scientific Foundations of Radiation Oncology PART A Radiobiology 1. The Biological Basis of Radiation Oncology 2. Molecular and Cellular Biology 3. Dose-Response Modifiers in Radiation Therapy 4. Interaction of Chemotherapy and Radiation 5. Modulation of Radiation Response with Molecularly Targeted Therapy 6. Cancer Immunity and Radiation
PART B Physics 7. Radiation Oncology Physics 8. Radiation Physics: Stereotactic 9. Radiation Physics: Charged Particle Therapy 10. Artificial Intelligence in Clinical Radiation Oncology
PART C related cancer Disciplines 11. Surgical Principles 12. Principles of Systemic Cancer Therapy 13. Imaging in Oncology 14. Nuclear Medicine and PET 15. Tumor Ablation in Interventional Radiology 16. Overview of Oncology Clinical Trial Design 17. Health Services Research in Radiation Oncology 18. Radiation Therapy in the Older Adult 19. Palliative Radiation Medicine 20. Late Effects After Radiation
SECTION 2 Techniques and Modalities 21. Quality and Safety in Radiation Oncology 22. Principles and Practice of Brachytherapy 23. Intensity-Modulated and Image-Guided Radiotherapy 24. Intraoperative Irradiation 25. Total Body Irradiation 26. Charged Particle Radiotherapy 27. Radiopharmaceutical Therapy 28. Radiotherapy and Immunotherapy 29. Stereotactic Irradiation: CNS Tumors 30. Stereotactic Body Irradiation: Extracranial Tumors 31. Metastatic Disease: Bone, Spinal Cord, Brain, Liver, and Lung
SECTION 3 Disease Sites PART A central nervous System tumors 32. Central Nervous System Tumors: Overview 33. Low-Grade Gliomas 34. High-Grade Gliomas 35. Benign Brain Tumors: Meningiomas and Vestibular Schwannomas 36. Pituitary Tumors and Craniopharyngiomas 37. Spinal Cord Tumors 38. Ocular, Orbital, and Optic Nerve Tumors
PART B Head and neck tumors 39. Overview 40. Oral Cavity 41. Oropharyngeal Cancer 42. Nasopharyngeal Carcinoma 43. Larynx and Hypopharynx Cancer 44. Sinonasal Cancer 45. Salivary Gland Malignancies 46. Thyroid Cancer 47. Unknown Head and Neck Primary Site 48. Management of the Neck 49. Cutaneous Carcinoma 50. Melanoma
PART C thoracic neoplasms 51. Overview 52. Small-Cell Lung Cancer 53. Non-small Cell Lung Cancer 54. Uncommon Thoracic Tumors
PART D Gastrointestinal tumors 55. Gastrointestinal Tumors Overview 56. Esophagus-Gastric Cancer 57. Pancreatic Cancer 58. Hepatobiliary Cancer 59. Colon Cancer 60. Rectal Cancer 61. Anal Carcinoma
PART E Genitourinary tumors 62. Overview 63. Prostate Cancer 64. Bladder Cancer 65. Testicular Cancer 66. Kidney and Ureteral Carcinoma 67. Penile Cancer
PART F Gynecologic tumors 68. Overview 69. Cervical Cancer 70. Endometrial Cancer 71. Cancers of the Vulva and Vagina 72. Ovarian Cancer
PART G Breast cancer 73. Overview 74. Noninvasive Breast Cancer 75. Breast Cancer: Stages I and II 76. Locally Advanced and Inflammatory Breast Cancer
PART H Sarcoma and Benign Disease 77. Soft-Tissue Sarcoma 78. Benign Diseases
PART I childhood cancers 79. Overview 80. Central Nervous System Tumors in Children 81. Pediatric Soft Tissue Sarcomas 82. Pediatric Sarcomas of Bone 83. Wilms’ Tumor 84. Retinoblastoma 85. Neuroblastoma 86. Pediatric Leukemia and Lymphoma 87. Pediatric Hodgkin Lymphoma 88. Rare Pediatric Tumors
PART J Lymphoma and Hematologic Malignancies 89. Overview 90. Hodgkin Lymphoma 91. Non-Hodgkin Lymphoma 92. Multiple Myeloma and Other Plasma Cell Neoplasms 93. Mycosis Fungoides
Robert L. Foote, MD, Hitachi Professor of Radiation Oncology Research, Mayo Clinic Alix School of Medicine, Department of Radiation Oncology Chair, Mayo Clinic Rochester Cancer Coordinating Committee, Mayo Clinic Cancer Center, Jeff M. Michalski, MD, MBA, FACR, FASTRO, Carlos A. Perez Distinguished Professor, Vice-Chairman and Director for Clinical Programs, Washington University School of Medicine Siteman Cancer Center, Department of Radiation Oncology, Akila Viswanathan, MD, MPH, MSc, Director, Johns Hopkins Radiation Oncology and Molecular Radiation Sciences, Professor of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine and Joel E. Tepper, MD, Hector MacLean Distinguished Professor of Cancer Research, Department of Radiation Oncology, University of North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
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