Diagnostic Pathology: Transplant Pathology, 3rd Edition

SECTION 1: IMMUNOLOGY

4 Immune Response in Organ Transplantation
Roshini Sarah Abraham, PhD
8 Regulatory Immune Cells and Transplant Tolerance
Roshini Sarah Abraham, PhD
14 Viral Infections and Immune Response
Sanya J. Thomas, MD and Roshini Sarah Abraham, PhD
20 Genetics of Complement Variants in Atypical HUS and TMA
Roshini Sarah Abraham, PhD
24 Laboratory-Based Immune Monitoring in Organ Transplantation
Sanya J. Thomas, MD and Roshini Sarah Abraham, PhD
30 Introduction to Xenotransplantation
Roshini Sarah Abraham, PhD
32 Graft-vs.-Host Disease in Solid Organ Transplantation
Sanya J. Thomas, MD and Roshini Sarah Abraham, PhD

SECTION2: HLA TESTING

36 Human Leukocyte Antigen System
Manish J. Gandhi, MD
38 Histocompatibility Testing
Manish J. Gandhi, MD
40 Transplantation and HLA
Manish J. Gandhi, MD
44 ABO Blood Group Antigens and Transplantation
Manish J. Gandhi, MD
46 Apheresis and Transplantation
Manish J. Gandhi, MD
48 HLA and Transfusion
Manish J. Gandhi, MD

SECTION 3: IMMUNOSUPPRESSIVE DRUGS

52 Mechanism of Action of Immunosuppressive Drugs
Loralie Langman, PhD and Florian Lemaitre, PharmD, PhD
54 Therapeutic Drug Monitoring in Transplant Patients
Loralie Langman, PhD and Florian Lemaitre, PharmD, PhD
58 History of Immunosuppression Drugs in Transplantation
Loralie Langman, PhD and Florian Lemaitre, PharmD, PhD

SECTION 4: KIDNEY TRANSPLANTATION

62 History of Kidney Transplantation
Lynn D. Cornell, MD
64 Pathologic Classification of Renal Allograft Diseases
Robert B. Colvin, MD
66 Examination of End-Stage Kidney
Shane Meehan, MB, BCh
72 Evaluation of End-Stage Kidney
Shane Meehan, MB, BCh
78 Evaluation of Allograft Kidney
Lynn D. Cornell, MD and Evan Farkash, MD, PhD
84 Evaluation of Donor Kidney
Lynn D. Cornell, MD and Evan Farkash, MD, PhD
90 Evaluation of Transplant Nephrectomy
Shane Meehan, MB, BCh and Evan Farkash, MD, PhD
94 Evaluation of Fibrosis
A. Brad Farris, III, MD, MBA
98 Protocol Biopsies
Lynn D. Cornell, MD and Evan Farkash, MD, PhD
102 Accommodation
Lynn D. Cornell, MD
104 Tolerance
Robert B. Colvin, MD

SURGICAL COMPLICATIONS

108 Acute Allograft Ischemia
A. Brad Farris, III, MD, MBA
112 Size Mismatch Allograft Injury
Anthony Chang, MD and Yael K. Heher, MD, MPH
114 Urine Leak
A. Brad Farris, III, MD, MBA
115 Lymphocele
A. Brad Farris, III, MD, MBA
116 Multinucleated Endotheliopathy
Jonathan Zuckerman, MD, PhD
120 Transplant Renal Artery Stenosis
A. Brad Farris, III, MD, MBA
122 Transplant Renal Artery or Vein Thrombosis
A. Brad Farris, III, MD, MBA
124 Kidney Xenografts
Ivy A. Rosales, MD

ALLOGRAFT REJECTION

128 Hyperacute Rejection
Lynn D. Cornell, MD and Michael Mengel, MD
132 Acute T-Cell-Mediated Rejection
Lynn D. Cornell, MD and Michael Mengel, MD
142 Chronic T-Cell-Mediated Rejection
Lynn D. Cornell, MD and Michael Mengel, MD
146 Acute Antibody-Mediated Rejection
Lynn D. Cornell, MD and Michael Mengel, MD
154 Chronic Antibody-Mediated Rejection
Lynn D. Cornell, MD and Michael Mengel, MD
166 Transcript Analysis of Renal Transplant Biopsies
Michael Mengel, MD and R. Neal Smith, MD, PhD

RECURRENT AND DE NOVO DISEASES

170 Diseases That Recur in Allografts
Anthony Chang, MD, Lynn D. Cornell, MD, and R. Neal Smith, MD, PhD
176 De Novo Focal Segmental Glomerulosclerosis
Anthony Chang, MD and Astrid Weins, MD, PhD
178 De Novo Membranous Nephropathy
Anthony Chang, MD
182 Anti-GBM Disease in Alport Syndrome
Anthony Chang, MD and R. Neal Smith, MD, PhD
184 Chimerism Transition Syndrome
A. Brad Farris, III, MD, MBA
186 Late Posttransplant Histology
Lynn D. Cornell, MD

KIDNEY PATHOLOGY OF RECIPIENTS OF OTHER TRANSPLANTS

188 Kidney Diseases in Nonrenal Transplant Recipients
Robert B. Colvin, MD
192 Graft-vs.-Host Glomerulopathies
Anthony Chang, MD and Yael K. Heher, MD, MPH

DRUG TOXICITIES

194 Calcineurin Inhibitor Toxicity
Shane Meehan, MB, BCh
200 mTOR Inhibitor Toxicity
Lynn D. Cornell, MD

INFECTIONS

202 Acute Pyelonephritis
Neeraja Kambham, MD
210 Polyomavirus Nephritis
Anthony Chang, MD and Evan Farkash, MD, PhD
218 Adenovirus Infection
Anthony Chang, MD and R. Neal Smith, MD, PhD
220 Cytomegalovirus Infection
Anthony Chang, MD and R. Neal Smith, MD, PhD
222 Mucormycosis
Anthony Chang, MD
224 Histoplasmosis
Anthony Chang, MD
225 Candidiasis
Anthony Chang, MD
226 Cryptococcosis
Anthony Chang, MD
227 Aspergillosis
Anthony Chang, MD
228 Coccidioidomycosis
Anthony Chang, MD
229 Paracoccidioidomycosis
Anthony Chang, MD
230 Microsporidiosis
Robert B. Colvin, MD
232 Tuberculosis
Neeraja Kambham, MD
234 Malakoplakia
Neeraja Kambham, MD
238 Nocardiosis
Neeraja Kambham, MD

SECTION 5: LIVER TRANSPLANTATION

242 Pathologic Classification of Liver Allograft Diseases
Lindsay Alpert, MD and John Hart, MD
244 Gross Evaluation of Native Liver
Lindsay Alpert, MD and John Hart, MD
248 Evaluation of Failed Liver Allograft
Lindsay Alpert, MD and John Hart, MD
250 Evaluation of Donor Liver
John Hart, MD
254 History of Liver Transplantation
Anthony Chang, MD and John Hart, MD

POSTTRANSPLANT SURGICAL COMPLICATIONS

256 Preservation Injury
Hanlin L. Wang, MD, PhD
258 Hepatic Artery Thrombosis
Lisa Yerian, MD and John Hart, MD
260 Portal Vein Thrombosis
Lisa Yerian, MD and John Hart, MD
262 Bile Duct Stricture, Leak, Sludge, Biloma
Hanlin L. Wang, MD, PhD
264 Hepatic Venous Outflow Obstruction
Hanlin L. Wang, MD, PhD
268 Small-for-Size (Hyperperfusion) Syndrome
Hanlin L. Wang, MD, PhD

ALLOGRAFT REJECTION

270 T-Cell-Mediated Rejection, Liver
Lisa Yerian, MD and John Hart, MD
274 Antibody-Mediated Rejection, Liver
Hanlin L. Wang, MD, PhD, Robert B. Colvin, MD, and Richard Masia, MD, PhD
278 Chronic (Ductopenic) Rejection
Matthew M. Yeh, MD, PhD and John Hart, MD

RECURRENT DISEASES IN LIVER ALLOGRAFT

280 Recurrent Hepatitis B Virus

Anthony Chang, MD, Director, UChicago Medical Laboratories, Director, Renal Pathology and Renal Pathology Fellowship, Associate Director, Pathology Residency Program, University of Chicago, Chicago, Illinois