Diagnostic Pathology: Thoracic, 4th Edition

by David I. Suster, MD, Mari Mino-Kenudson, MD and Saul Suster, MD

Hardcover

ISBN: 9780443411632

Page Count: 850

Imprint: Elsevier

List Price: $340.99

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Key Features
- Provides a clear framework for a better understanding of the clinical and histopathologic findings of pulmonary, pleural, and mediastinal entities; as well as an intuitive structure that organizes chapters by neoplastic and nonneoplastic lesions and pseudotumoral conditions of the lung
- Offers major additions to the molecular pathology sections for all relevant entities, specifying the types of genetic mutations found in those tumors, covering next-generation sequencing and other molecular diagnostic techniques, and detailing the ways these genetic alterations can be used by pathologists to distinguish diseases
- Features new chapters on lung allograft pathology; pulmonary chondroma in Carney syndrome; new soft tissue tumor entities, including clear cell stromal tumor of the lung; and new salivary gland tumors, including hyalinizing clear cell carcinoma
- Contains timely updates for mesothelioma grading, squamous cell carcinoma grading, and thymic epithelial tumor diagnostics, including new information on thymic carcinoma; new additions to atypical and conventional thymoma; updated content on molecular genetics of thymic tumors; and new molecular genetic and diagnostic biomarker details for several bone and soft tissue chapters, including nomenclature and classification changes for certain soft tissue tumors
- Features updated criteria and classification of interstitial lung disease based on the 2025 International Multidisciplinary Classification of Interstitial Pneumonias from the American Thoracic Society (ATS) and European Respiratory Society (ERS)
- Provides important updates that reflect the 2026 World Health Organization (WHO) Classification of Lung Tumors as well as the 2026 molecular testing guidelines from the College of American Pathologists (CAP), Association for Molecular Pathology (AMP), and International Association for the Study of Lung Cancer (IASLC)
- Features a templated, highly formatted design and concise, bulleted text; diagnostic pearls, a Key Facts summary in every chapter; and an extensive index for easy reference
- Contains nearly 3,000 high-quality print images (with an additional 900+ images in the complimentary eBook), including gross pathology, radiology, and histology images, and full-color medical illustrations—all carefully annotated to help you quickly recognize established entities
- Includes an eBook version that allows you access to everything in the book as well as additional text, figures, and references, with the ability to search, make notes and highlights, and have content read aloud; additional digital ancillary content may publish up to 6 weeks following the publication date
Contents

PART I: LUNG

Section 1: Neoplasms, Benign

Congenital Peribronchial Myofibroblastic Tumor
Fetal Lung Interstitial Tumor
Mucous Gland Adenoma
Ciliated Muconodular Papillary Tumor/Bronchiolar Adenoma
Alveolar Adenoma
Sclerosing Pneumocytoma
Cartilaginous Hamartoma
Endobronchial Lipoma
Pulmonary Adenofibroma/Adenomyoma
Glomus Tumor
Pulmonary Paraganglioma
Pulmonary Meningioma
Minute Pulmonary Meningothelial-Like Nodule
Granular Cell Tumor
Langerhans Cell Histiocytosis
Erdheim-Chester Disease
Pulmonary PEComa (Clear Cell Sugar Tumor)
Lymphangioleiomyomatosis

Section 2: Other Rare Tumors and Benign Pseudotumoral Conditions

Inflammatory Myofibroblastic Tumor
Intrapulmonary Thymoma
Juvenile Xanthogranuloma
Hyalinizing Granuloma
Metastatic/Dendriform Calcification
Lipoid Pneumonia
Placental Transmogrification
Rosai-Dorfman Disease
Epithelioid Hemangioma

Section 3: Neoplasms, Malignant, Primary

ADENOCARCINOMA

Overview of Malignant Epithelial Neoplasms of Lung
Conventional Adenocarcinoma
Lepidic-Predominant Adenocarcinoma

Adenocarcinoma Variants

Invasive Mucinous Adenocarcinoma
Colloid Adenocarcinoma
Fetal Adenocarcinoma
Enteric-Type Adenocarcinoma
Other Adenocarcinoma Variants
Adenosquamous Carcinoma

SQUAMOUS CELL CARCINOMA

Conventional Squamous Cell Carcinoma
Basaloid/Small Cell Variant of Squamous Cell Carcinoma
Lymphoepithelioma-Like Carcinoma

NEUROENDOCRINE CARCINOMA AND PRECURSOR LESIONS

Overview of Neuroendocrine Neoplasms
Pulmonary Tumorlet and Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia
Low-Grade Neuroendocrine Carcinoma (Typical Carcinoid Tumor)
Intermediate-Grade Neuroendocrine Carcinoma (Atypical Carcinoid Tumor)
High-Grade Neuroendocrine Carcinoma, Small Cell Type
High-Grade Neuroendocrine Carcinoma, Large Cell Type

POORLY DIFFERENTIATED NON-SMALL CELL CARCINOMAS

Overview of Poorly Differentiated Non-Small Cell Carcinomas
Large Cell Carcinoma
Pleomorphic Carcinoma
Spindle Cell Carcinoma
Carcinosarcoma
Pulmonary Blastoma
SMARCA4-Deficient Undifferentiated Tumors
NUT Carcinoma

SALIVARY GLAND-TYPE TUMORS

Adenoid Cystic Carcinoma
Mucoepidermoid Carcinoma of Lung
Epithelial-Myoepithelial Carcinoma
Acinic Cell Carcinoma
Mixed Tumor (Pleomorphic Adenoma)
Myoepithelial Carcinoma

MESENCHYMAL NEOPLASMS

Pleuropulmonary Blastoma
Primary Pulmonary Myxoid Sarcoma
Intrapulmonary Solitary Fibrous Tumor
Leiomyosarcoma of Lung
Intrapulmonary Synovial Sarcoma
Malignant Peripheral Nerve Sheath Tumor of Lung
Osteosarcoma
Chondrosarcoma
Epithelioid Hemangioendothelioma of Lung
Angiosarcoma of Lung
Kaposi Sarcoma
Intimal Sarcoma

LYMPHOPROLIFERATIVE DISORDERS

Benign Pulmonary Lymphoid Lesions
Pulmonary BALT Lymphoma
Diffuse Large Cell Lymphoma of Lung
Intravascular Large B-Cell Lymphoma
Hodgkin Lymphoma of Lung
Plasmacytoma
Lymphomatoid Granulomatosis

OTHER NEOPLASMS

Primary Pulmonary Melanoma
Ganglioneuroblastoma

Section 4: Neoplasms, Metastatic

Benign Metastasizing Leiomyoma
Metastatic Carcinoma
Metastatic Sarcoma
Metastatic Malignant Melanoma

Section 5: Nonneoplastic and Systemic Conditions

Diffuse Alveolar Damage
Acute Fibrinous and Organizing Pneumonia
Organizing Pneumonia
Eosinophilic Pneumonia
Respiratory Bronchiolitis Interstitial Lung Disease
Desquamative Interstitial Pneumonia
Other Smoking-Related Changes
Usual Interstitial Pneumonia
Nonspecific Interstitial Pneumonia
Granulomatous-Lymphocytic Interstitial Lung Disease
Pleuroparenchymal Fibroelastosis
Hypersensitivity Pneumonitis
Bronchocentric Granulomatosis
Sarcoidosis
IgG4-Related Disease
Pulmonary Amyloidosis
Light Chain Deposition Disease (Pseudoamyloid)
Diffuse Alveolar Hemorrhage With and Without Capillaritis
Granulomatosis With Polyangiitis (Wegener Granulomatosis)
Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss)
Microscopic Polyangitis
Pulmonary Venoocclusive Disease/Pulmonary Capillary Hemangiomatosis
Idiopathic Pulmonary Hemosiderosis
Hard Metal Pneumoconiosis
Asbestos-Related Interstitial Fibrosis/Asbestosis
E-Cigarette and Vaping-Associated Lung Injury
Alveolar Proteinosis
Alveolar Microlithiasis
Congenital Pulmonary Airway Malformations

Section 6: Infectious Diseases

PARASITIC

Strongyloidiasis
Dirofilariasis
Schistosomiasis
Echinococcosis (Hydatid Cyst)
Paragonimiasis

FUNGAL

Cryptococcosis
Coccidioidomycosis
Pneumocystosis
Blastomycosis
Histoplasmosis
Aspergillosis
Mucormycosis (Zygomycosis)
Sporotrichosis

BACTERIAL

Tuberculosis
Klebsiella Pneumonia
Legionnaires' Disease
Nocardiosis
Actinomycosis
Botryomycosis
Malakoplakia

VIRAL

Herpes Simplex Virus
Cytomegalovirus
Adenovirus
SARS/COVID-19 Pneumonia
Measles Pneumonia

PART II: PLEURA

Section 1: Benign Tumors and Reactive Conditions

Solitary Fibrous Tumor of Pleura
Calcified Fibrous Pseudotumor
Pleuropulmonary Endometriosis
Mesothelial Hyperplasia

Section 2: Neoplasms, Malignant, Primary

Overview of Malignant Pleural Neoplasms

MESOTHELIAL NEOPLASMS

Well-Differentiated Papillary Mesothelioma
Malignant Mesothelioma

OTHER MALIGNANT NEOPLASMS

Mucoepidermoid Carcinoma of Pleura
Angiosarcoma of Pleura
Synovial Sarcoma of Pleura
Smooth Muscle Tumors of Pleura
Desmoplastic Small Round Cell Tumor
Primary Effusion Lymphoma

PART III: MEDIASTINUM

Section 1: Benign Tumors and Reactive Conditions

Lymphangioma
Hemangioma
Paraganglioma
Schwannoma
Neurofibroma
Ectopic Parathyroid Tumor
Ectopic Thyroid Tumor
Thymolipoma
Castleman Disease
Simple (Benign) Mediastinal Cysts
Acquired Multilocular Thymic Cyst
Idiopathic Sclerosing Mediastinitis
Authors

David I. Suster, MD, Associate Professor, Director, Surgical Pathology, Department of Pathology, Rutgers University, New Jersey Medical School, Newark, New Jersey, Mari Mino-Kenudson, MD, Professor of Pathology, Harvard Medical School, Division Chief of Anatomic Pathology for Mass General Brigham, Director of Pulmonary Pathology Service, Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts and Saul Suster, MD, Professor and Chairman Emeritus, Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin