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cover image - Clinical Immunology,6th Edition
ISBN: 9780702081651
Publication Date: 12-06-2022
Page Count: 1344
Imprint: Elsevier
List Price: $314.99

Clinical Immunology, 6th Edition

by Robert R. Rich, MD, Thomas A. Fleisher, MD, FAAAAI, FACAAI, Harry W. Schroeder Jr., MD, PhD, Cornelia M. Weyand, MD, PhD, David B. Corry and Jennifer M. Puck


cover image - Clinical Immunology,6th Edition
ISBN: 9780702081651
Publication Date: 12-06-2022
Page Count: 1344
Imprint: Elsevier
    • Includes extensive revisions that reflect rapidly expanding research and clinical advances, including breakthrough drug and immunotherapies such as immune checkpoint inhibitors, immunotherapies for cancer, precision medicine, and transfusion medicine.
    • Contains new chapters on COVID-19, immune responses, and the role of the immune system; immunoregulatory deficiencies; immune checkpoints; CAR T cells, including new cellular-based immunotherapy; gene therapy, including CRISPR and gene selection; and a clinically focused chapter on asthma.
    • Provides new genetics content focused on data applications.
    • Addresses notable advances in key areas such as the importance of the microbiota to normal immune system development and to the pathogenesis of immunologic and inflammatory diseases; relationships between the innate and adaptive immune systems; progress in rapid and cost-effective genomics; cell signaling pathways and the structure of cell-surface molecules; and many more.
    • Covers hot topics such as the role of genetics and genomics in immune response and immunologic disease, atherosclerosis, recurrent fever syndromes, aging and deficiencies of innate immunity, the role of microbiota in normal immune system development and in the pathogenesis of immunologic and inflammatory diseases, and novel therapeutics.
    • Features a user-friendly format with color-coded boxes highlighting critical information on Key Concepts, Clinical Pearls, Clinical Relevance, and Therapeutic Principles.
    • Summarizes promising research and development anticipated over the next 5–10 years with "On the Horizon" boxes and discussions of translational research.
    • An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
  • PART I Principles of Immune Response
    1 The Human Immune Response
    2 Organization of the Immune System
    3 Innate Immunity
    4 Antigen Receptor Genes, Gene Products, and Co-Receptors
    5 The Major Histocompatibility Complex
    6 Antigens and Antigen Presentation
    7 B-Cell Development and Differentiation
    8 Immunoglobulin Function
    9 T-Cell Development
    10 T-Cell Activation and Tolerance
    11 Helper T-Cell Subsets and Control of the Inflammatory Response
    12 Cytotoxic T Lymphocytes and Natural Killer Cells
    13 Regulatory Immune Cells
    14 Cytokines and Cytokine Receptors
    15 Chemokines and Chemokine Receptors
    16 Lymphocyte Adhesion and Trafficking
    17 Death Pathways and Immunogenicity
    PART II Fundamentals of Host-Environmental Interactions
    18 Human Genomics in Immunology
    19 Regulatory RNA in Immunologic Diseases
    20 Immunometabolism
    21 Immune Deficiencies at the Extremes of Age
    22 The Microbiota in Immunity and Inflammation
    PART III Host Defenses to Infectious Agents
    23 Immunology of the Skin
    24 Immunology of Mucosal Surfaces
    25 Host Defenses to Viruses
    26 Host Defenses to Intracellular Bacteria
    27 Host Defenses to Extracellular Bacteria, Including Spirochetes
    28 Host Defenses to Fungi
    29 Host Defenses to Protozoa
    30 Host Defenses to Helminth Infection
    31 Emerging Pandemic Infectious Disease Threats
    PART IV Immune Deficiency and Immune Regulatory Disorders
    32 Approach to the Evaluation of the Patient With Suspected Immunodeficiency
    33 Primary Antibody Deficiencies
    34 Primary T-Cell Immunodeficiencies
    35 Genetic Disorders of Interferons-, Interleukin-17, Interleukin-18, and Nuclear Factor-?B-Mediated Immunity
    36 Hemophagocytic Lymphohistiocytosis
    37 Autoinflammatory Syndromes
    38 Immune Regulatory Disorders
    39 Neutrophils and Neutrophil Disorders
    40 Complement and Complement Disorders
    41 Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome
    42 Autoantibody-Mediated Phenocopies of Primary Immunodeficiency Diseases
    PART V Allergic Diseases
    43 Allergic Airway Diseases
    44 Mast Cells and Mast Cell Disorders
    45 Eosinophils and Eosinophilic Disorders
    46 Urticaria, Angioedema, and Anaphylaxis
    47 Allergic Reactions to Stinging and Biting Insects
    48 Atopic and Contact Dermatitis
    49 Food Allergy
    50 Drug Hypersensitivity
    PART VI Systemic Immune Diseases
    51 Mechanisms of Autoimmunity
    52 Systemic Lupus Erythematosus
    53 Rheumatoid Arthritis
    54 Juvenile Idiopathic Arthritis
    55 Sjögren’s Syndrome
    56 Scleroderma-Systemic Sclerosis
    57 Inflammatory Muscle Diseases
    58 Spondyloarthritis
    59 Small- and Medium-Vessel Primary Vasculitis
    60 Large Vessel Vasculitides
    61 Antiphospholipid Syndrome
    PART VII Organ-Specific Inflammatory Disease
    62 Immunohematologic Disorders
    63 Bullous Diseases of the Skin and Mucous Membranes
    64 Immunology of Psoriasis
    65 Myasthenia Gravis
    66 Multiple Sclerosis
    67 Autoimmune Peripheral Neuropathies
    68 Immunologic Renal Diseases
    69 Immunologic Mechanisms of Atherosclerosis and Myocarditis
    70 Autoimmune Thyroid Diseases
    71 Type 1 Diabetes
    72 Immunologic Lung Diseases, 919
    73 Chronic Obstructive Pulmonary Disease and Emphysema
    74 Immunologic Ocular Disease
    75 Immunologic Diseases of the Gastrointestinal Tract
    76 Inflammatory Hepatobiliary Diseases
    PART VIII Immunology and Immunotherapy of Neoplasia
    77 Lymphoid Leukemias
    78 Lymphomas
    79 Monoclonal Gammopathies
    80 Immune Responses to Solid Tumors and Immune Checkpoint Therapy
    81 CAR T-Cell Therapy
    PART IX Medical Management of Immunological Diseases
    82 Immunoglobulin Therapy: Replacement and Immunomodulation
    83 Glucocorticoids
    84 Immunomodulating Drugs
    85 Protein Kinase Antagonists
    86 Biologic Response Modifiers
    87 Vaccines
    88 Allergen Immunotherapy for Allergic Diseases
    PART X Transplantation
    89 Solid Organ Transplantation: Rejection, Immunosuppression, and Tolerance
    90 Allogeneic Transplantation for Immunodeficiency
    91 Gene Therapy for Primary Immune Deficiency Diseases
    92 Hematopoietic Stem Cell Transplantation for Malignant Diseases
    PART XI Diagnostic Immunology
    93 Flow Cytometry
    94 Assessment of Functional Immune Responses in Lymphocytes
    95 Assessment of Neutrophil Function
    96 Assessment of Human Allergic Diseases
    Appendix 1: Selected CD Molecules and Their Characteristics
    Appendix 2: Laboratory Reference Values
  • Robert R. Rich, MD, Professor of Medicine and Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA, Thomas A. Fleisher, MD, FAAAAI, FACAAI, Adjunct Professor of Pediatrics, USUHA, Chief, Department of Laboratory Medicine, NIH Clinical Center, National Institutes of Health, Bethesda MD, USA, Harry W. Schroeder Jr., MD, PhD, Professor of Medicine, Microbiology, and Genetics, Division of Clinical Immunology and Rheumatology, Director, UAB Program in Immunology, University of Alabama at Birmingham, Birmingham, AL, USA, Cornelia M. Weyand, MD, PhD, Professor of Medicine, Stanford University School of Medicine, Department of Medicine: Immunology and Rheumatology, Stanford, CA, USA, David B. Corry and Jennifer M. Puck