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Fundamentals of Molecular Diagnostics

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Hardcover

Fundamentals of Molecular Diagnostics

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This book offers an introduction to the newest, fastest-growing field in laboratory science. Explaining and clarifying the molecular techniques used in diagnostic testing, this text provides both entry-level and advanced information. It covers the principles of molecular biology along with genomes and nucleic acid alterations, techniques and instrumentation, and applications of molecular diagnostics. Written by leading experts, including Patrick Bossuyt, Angela Caliendo, Rossa W.K. Chiu, Kojo S.J. Elenitoba-Johnson, Andrea Ferreira-Gonzalez, Amy Groszbach, Sultan Habeebu, Doris Haverstick, Malek Kamoun, Anthony Killeen, Noriko Kusukawa, Y.M. Dennis Lo, Elaine Lyon, Gwendolyn McMillin, Christopher Price, James Versalovic, Cindy Vnencak-Jones, Victor Weedn, Peter Wilding, Thomas Williams, and Carl Wittwer, this book includes illustrations, tables, and a colorful design to make information easy to find and easy to use.
  • A full-color, 4-page insert shows realistic images of the output for many molecular tests.
  • Learning Objectives open each chapter with an overview of what you should achieve.
  • Key Words are listed and defined at the beginning of each chapter, and are bolded in the text.
  • Review Questions at the end of every chapter let you measure your comprehension.
  • Advanced Concepts are included, but set apart from the rest of the text, for students who want a higher level of learning.
  • Ethics boxes address ethical issues, allowing you to apply your knowledge to real-life scenarios.
  • A glossary of all key words may be easily accessed in the back of the book.
I. Principles

1. Principles of Molecular Biology

2. Genomes and Nucleic Acid Alterations

II. Techniques and Instrumentation

3. Specimen Collection and Processing

4. Nucleic Acid Isolation

5. Nucleic Acid Techniques

6. Miniaturization: DNA Chips and Devices

7. Design and Operation of a Molecular Diagnostics Laboratory

8. Introduction to Evidence-Based Molecular Diagnostics

III. Applications

9. Inherited Diseases

10. Identity Assessment

11. Molecular Methods in Diagnosis and Monitoring of Infectious Diseases

12. Pharmacogenetics

13. Molecular Genetics in Diagnosis of Human Cancers

IV. Appendix

14. Reference Information

Answers to Review Questions

Glossary
David E. Bruns, MD, Professor of Pathology, University of Virginia School of Medicine, Director of Clinical Chemistry and Associate Director of Molecular Diagnostics, University of Virginia Health System, Charlottesville, VA, and Former Editor, Clinical Chemistry, Washington, DC, Edward R. Ashwood, MD, Professor of Pathology, University of Utah School of Medicine, and President and CEO, ARUP Laboratories, Salt Lake City, UT and Carl A. Burtis, PhD, Health Services Division, Oak Ridge National Laboratory, Oak Ridge, TN, and Clinical Professor of Pathology, University of Utah School of Medicine, Salt Lake City, UT
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