Provides more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than any other infectious disease resource.
Features an increased focus on antibiotic stewardship; new antivirals for influenza, cytomegalovirus, hepatitis C, hepatitis B., and immunizations; and new recommendations for vaccination against infection with pneumococci, papillomaviruses, hepatitis A, and pertussis.
Covers newly recognized enteroviruses causing paralysis (E-A71, E-D68); emerging viral infections such as Ebola, Zika, Marburg, SARS, and MERS; and important updates on prevention and treatment of C. difficile infection, including new tests that diagnose or falsely over-diagnose infectious diseases.
Offers fully revised content on bacterial pathogenesis, antibiotic use and toxicity, the human microbiome and its effects on health and disease, immunological mechanisms and immunodeficiency, and probiotics and alternative approaches to treatment of infectious diseases.
Discusses up-to-date topics such as use of the new PCR panels for diagnosis of meningitis, diarrhea and pneumonia; current management of infected orthopedic implant infections; newly recognized infections transmitted by black-legged ticks in the USA: Borrelia miyamotoi and Powassan virus; infectious complications of new drugs for cancer; new drugs for resistant bacteria and mycobacteria; new guidelines for diagnosis and therapy of HIV infections; and new vaccines against herpes zoster, influenza, meningococci.
PPID continues its tradition of including leading experts from a truly global community, including authors from Australia, Canada and countries in Europe, Asia, and South America.
Includes regular updates online for the life of the edition.
Features more than 1,500 high-quality, full-color photographs—with hundreds new to this edition.
Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices.
I Basic Principles in the Diagnosis and Management of Infectious Diseases A MICROBIAL PATHOGENESIS 1 A Molecular Perspective of Microbial Pathogenicity 2 The Human Microbiome of Local Body Sites and Their Unique Biology 3 Prebiotics, Probiotics, and Synbiotics B HOST DEFENSE MECHANISMS 4 Innate (General or Nonspecific) Host Defense Mechanisms 5 Adaptive Immunity: Antibodies and Immunodeficiencies 6 Cell-Mediated Defense Against Infection 7 Mucosal Immunity 8 Granulocytic Phagocytes 9 Complement and Deficiencies 10 Human Genetics and Infection 11 Nutrition, Immunity, and Infection 12 Evaluation of the Patient With Suspected Immunodeficiency C EPIDEMIOLOGY OF INFECTIOUS DISEASE 13 Applied Epidemiology for the Infectious Diseases Physician 14 Emerging and Reemerging Infectious Disease Threats 15 Bioterrorism: An Overview D CLINICAL MICROBIOLOGY 16 The Clinician and the Microbiology Laboratory: Test Ordering, Specimen Collection, and Result Interpretation E ANTIINFECTIVE THERAPY 17 Principles of Antiinfective Therapy 18 Molecular Mechanisms of Antibiotic Resistance in Bacteria 19 Pharmacokinetics and Pharmacodynamics of Antiinfective Agents 20 Penicillins and ß-Lactamase Inhibitors 21 Cephalosporins 22 Ertapenem, Imipenem, Meropenem, Doripenem, and Aztreonam 23 Antibiotic Allergy 24 Fusidic Acid 25 Aminoglycosides 26 Tetracyclines, Glycylcyclines, and Chloramphenicol 27 Rifamycins 28 Metronidazole 29 Macrolides and Clindamycin 30 Glycopeptides (Vancomycin and Teicoplanin) and Lipoglycopeptides (Telavancin, Oritavancin, and Dalbavancin) 31 Daptomycin and Quinupristin-Dalfopristin 32 Polymyxins (Polymyxin B and Colistin) 33 Linezolid, Tedizolid, and Other Oxazolidinones 34 Sulfonamides and Trimethoprim; Trimethoprim-Sulfamethoxazole 35 Quinolones 36 Unique Antibacterial Agents 37 Urinary Tract Agents: Nitrofurantoin, Fosfomycin, and Methenamine 38 Topical Antibacterials 39 Antimycobacterial Agents 40A Antifungal Agents: Amphotericin B 40B Antifungal Drugs: Azoles 40C Antifungal Drugs: Echinocandins 40D Antifungal Drugs: Flucytosine 41 Antimalarial Drugs 42 Drugs for Protozoal Infections Other Than Malaria 43 Drugs for Helminths 44 Antiviral Agents: General Principles 45 Antiviral Drugs for Influenza and Other Respiratory Virus Infections 46 Antivirals Against Herpesviruses 47 Antiviral Drugs Against Hepatitis Viruses 48 Miscellaneous Antiviral Agents (Interferons, Tecovirimat, Imiquimod, Pocapavir, Pleconaril) 49 Immunomodulators 50 Hyperbaric Oxygen 51 Antimicrobial Stewardship 52 Designing and Interpreting Clinical Studies in Infectious Diseases 53 Outpatient Parenteral Antimicrobial Therapy 54 Tables of Antiinfective Agent Pharmacology II Major Clinical Syndromes A FEVER 55 Temperature Regulation and the Pathogenesis of Fever 56 Fever of Unknown Origin 57 The Acutely Ill Patient With Fever and Rash B UPPER RESPIRATORY TRACT INFECTIONS 58 The Common Cold 59 Pharyngitis 60 Acute Laryngitis 61 Otitis Externa, Otitis Media, and Mastoiditis 62 Sinusitis 63 Epiglottitis 64 Infections of the Oral Cavity, Neck, and Head C PLEUROPULMONARY AND BRONCHIAL INFECTIONS 65 Acute Bronchitis 66 Acute Exacerbations of Chronic Obstructive Pulmonary Disease 67 Acute Pneumonia 68 Pleural Effusion and Empyema 69 Bacterial Lung Abscess 70 Chronic Pneumonia 71 Cystic Fibrosis D URINARY TRACT INFECTIONS 72 Urinary Tract Infections E SEPSIS 73 Sepsis and Septic Shock F INTRAABDOMINAL INFECTIONS 74 Peritonitis and Intraperitoneal Abscesses 75 Infections of the Liver and Biliary System (Liver Abscess, Cholangitis, Cholecystitis) 76 Pancreatic Infection 77 Splenic Abscess 78 Appendicitis 79 Diverticulitis and Neutropenic Enterocolitis G CARDIOVASCULAR INFECTIONS 80 Endocarditis and Intravascular Infections 81 Prosthetic Valve Endocarditis 82 Infections of Nonvalvular Cardiovascular Devices 83 Prevention of Infective Endocarditis 84 Myocarditis and Pericarditis 85 Mediastinitis H CENTRAL NERVOUS SYSTEM INFECTIONS 86 Approach to the Patient With Central Nervous System Infection 87 Acute Meningitis 88 Chronic Meningitis 89 Encephalitis 90 Brain Abscess 91 Subdural Empyema, Epidural Abscess, and Suppurative Intracranial Thrombophlebitis 92 Cerebrospinal Fluid Shunt and Drain Infections I SKIN AND SOFT TISSUE INFECTIONS 93 Cellulitis, Necrotizing Fasciitis, and Subcutaneous Tissue Infections 94 Myositis and Myonecrosis 95 Lymphadenitis and Lymphangitis J GASTROINTESTINAL INFECTIONS AND FOOD POISONING 96 Syndromes of Enteric Infection 97 Esophagitis 98 Diarrhea With Little or No Fever 99 Acute Dysentery Syndromes (Diarrhea With Fever) 100 Typhoid Fever, Paratyphoid Fever, and Typhoidal Fevers 101 Foodborne Disease 102 Tropical Sprue and Environmental Enteric Dysfunction K BONE AND JOINT INFECTIONS 103 Infectious Arthritis of Native Joints 104 Osteomyelitis 105 Orthopedic Implant–Associated Infections L DISEASES OF THE REPRODUCTIVE ORGANS AND SEXUALLY TRANSMITTED DISEASES 106 Genital Skin and Mucous Membrane Lesions 107 Urethritis 108 Vulvovaginitis and Cervicitis 109 Infections of the Female Pelvis 110 Prostatitis, Epididymitis, and Orchitis M EYE INFECTIONS 111 Introduction to Eye Infections 112 Microbial Conjunctivitis 113 Microbial Keratitis 114 Endophthalmitis 115 Infectious Causes of Uveitis 116 Periocular Infections N HEPATITIS 117 Viral Hepatitis O ACQUIRED IMMUNODEFICIENCY SYNDROME 118 Global Perspectives on Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome 119 Epidemiology and Prevention of AIDS and HIV Infection, Including Preexposure Prophylaxis and HIV Vaccine Development 120 Diagnosis of Human Immunodeficiency Virus Infection 121 The Immunology of Human Immunodeficiency Virus Infection 122 General Clinical Manifestations of Human Immunodeficiency Virus Infection (Including Acute Retroviral Syndrome and Oral, Cutaneous, Renal, Ocular, Metabolic, and Cardiac Diseases) 123 Pulmonary Manifestations of Human Immunodeficiency Virus Infection 124 Gastrointestinal, Hepatobiliary, and Pancreatic Manifestations of Human Immunodeficiency
John E. Bennett, MD, Adjunct Professor of Medicine, Uniformed Services University of the Health Sciences, F. Edward Hebert School of Medicine, Bethesda, Maryland, Raphael Dolin, MD, Maxwell Finland Professor of Medicine (Microbiology & Molecular Genetics), Harvard Medical School; Attending Physician, Beth Israel Deaconess Medical Center Brigham and Women's Hospital, Boston, Massachusetts and Martin J. Blaser, MD, Henry Rutgers Chair of the Human Microbiome, Professor of Medicine and Pathology & Laboratory Medicine - RWJMS; Director, Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey, USA
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