Provide your students with the in-depth understanding of pathophysiology they need for patient care! Using a systems approach, Pathophysiology, 8th Edition, examines the etiology, pathogenesis, clinical manifestations, and treatment of diseases and disorders. The book begins with a review of normal anatomy and physiology, followed by pathophysiology and application of concepts to specific disorders. Each chapter includes a discussion of the disease processes and abnormalities that may occur, with a focus on the pathophysiologic concepts involved. Using a clear, concise writing style and a focus on critical thinking, this text emphasizes the major pathophysiology concepts relevant to clinical practice while not overwhelming the reader with minute detail.
NEW!Updated content throughout the book reflects the latest research and thinking in pathophysiology
Clear, easy-to-read writing style is simplified by input from readability experts, and includesmany tables, boxes, and figures to highlight key content
Thorough updates include information on the newest scientific findings and advances in treatment, more than 100 new figures for improved clarity, and more
More than 1,000 full-color photos and illustrations help to clarify complex pathophysiological concepts and make the book visually appealing
Global Health Care boxes summarize topics such asCOVID-19, HIV/AIDS, Ebola, tropical diseases, and more, with information on prevalence, mechanism of disease and transmission
Pediatric and Older Adult Considerations boxes include brief analyses of age-related changes associated with specific body systems
Student-friendly learning resources include chapter outlines, bolded key terms, key questions, Key Points boxes, Clinical Judgment challenges, and chapter summaries
UNIT I Pathophysiologic Processes 1 Introduction to Pathophysiology 2 Homeostasis Allostasis and Adaptive Responses to Stressors
UNIT II Cellular Function 3 Cell Structure and Function 4 Cell Injury Aging and Death 5 Genome Structure Regulation and Tissue Differentiation 6 Genetic and Developmental Disorders 7 Neoplasia
UNIT III Defense 8 Infectious Processes 9 Inflammation and Immunity 10 Alterations in Immune Function 11 Malignant Disorders of White Blood Cells 12 HIV Disease and Aids
UNIT IV Oxygen Transport Blood Coagulation Blood Flow and Blood Pressure 13 Alterations in Oxygen Transport 14 Alterations in Hemostasis and Blood Coagulation 15 Alterations in Blood Flow 16 Alterations in Blood Pressure
UNIT V Cardiac Function 17 Cardiac Function 18 Alterations in Cardiac Function 19 Heart Failure and Dysrhythmias 20 Shock
UNIT VI Respiratory Function 21 Respiratory Function and Alterations in Gas Exchange 22 Obstructive Pulmonary Disorders 23 Restrictive Pulmonary Disorders
UNIT VII Fluid Electrolyte and Acid-Base Homeostasis 24 Fluid and Electrolyte Homeostasis and Imbalances 25 Acid-Base Homeostasis and Imbalances
UNIT VIII Renal and Bladder Function 26 Renal Function 27 Intrarenal Disorders 28 Acute Kidney Injury and Chronic Kidney Disease 29 Disorders of the Lower Urinary Tract
UNIT IX Genital and Reproductive Function 31 Alterations in Male Genital and Reproductive Function 32 Female Genital and Reproductive Function 33 Alterations in Female Genital and Reproductive Function 34 Sexually Transmitted Infections
UNIT X Gastrointestinal Function 36 Gastrointestinal Disorders 37 Alterations in Function of the Gallbladder and Exocrine Pancreas 38 Liver Diseases
UNIT XI Endocrine Function Metabolism and Nutrition 39 Endocrine Physiology and Mechanisms of Hypothalamic Pituitary Regulation 40 Disorders of Endocrine Function 41 Diabetes Mellitus 42 Alterations in Metabolism and Nutrition
UNIT XII Neural Function 43 Structure and Function of the Nervous System 44 Acute Disorders of Brain Function 45 Chronic Disorders of Neurologic Function 46 Alterations in Special Sensory Function 47 Pain
UNIT XIII Neuropsychological Function 48 Mental Health Disorders UNIT XIV Musculoskeletal Support and Movement 49 Structure and Function of the Musculoskeletal System 50 Alterations in Musculoskeletal Function Trauma Infection and Disease 51 Alterations in Musculoskeletal Function Rheumatic Disorders
UNIT XV Integumentary System 52 Alterations in the Integumentary System 53 Burn Injuries
The appearance of the text and page layout can be modified according to the capabilities of the reading system (font family and font size, spaces between paragraphs, sentences, words, and letters, as well as color of background and text)
This e-publication is accessible to the full extent that the file format and types of content allow, on a specific reading device, by default, without necessarily including any additions such as textual descriptions of images or enhanced navigation
All content can be read as read aloud speech or dynamic braille
Has alternative text descriptions for images
Conformance
The certifier's credential is https://bornaccessible.benetech.org/certified-publishers/
For queries regarding accessibility information, contact [email protected]
The publication was certified on 26-11-2025
Navigation
Table of contents to all chapters of the text via links
Index with links to referenced entries
Elements such as headings, tables, etc. for structured navigation
Page list to go to pages from the print source version
Rich Content
Math formulas in accessible format (MathML)
Chemical formulas in accessible format (MathML)
Information-rich images are described by extended descriptions
Hazards
The publication contains no hazards
Product Content
Content includes any type of illustrations.
The primary content is text.
Content includes maps and/or other cartographic content.
Content includes a significant number of actionable (clickable) web links to external content, downloadable resources, supplementary material, etc.
Content includes a significant number of actionable (clickable) cross-references, hyperlinked notes and annotations, or with other actionable links between largely textual elements (e.g., quiz/test questions, 'choose your own ending', etc.).
Content includes additional textual content such as an interview, feature article, essay, bibliography, quiz/test, other background material, or text that is not included in a primary or 'unenhanced' version.
Content includes photographs, whether in a plate section / insert or not.
Content includes figures, diagrams, charts and/or graphs, including other 'mechanical' (i.e. non-photographic) illustrations.
Content includes a significant number of web links (printed URLs, QR codes etc.).
Content includes text within images, including text-as-text embedded in diagrams, charts, or within images containing speech balloons, thought bubbles, captions, etc.
Content includes chemical notations, formulae.
Content includes mathematical notations, formulae.
At least some text - including text within other images - is 'text as an image' (i.e., a picture of text).
Legal Considerations
No information is available
Additional Accessibility Information
Content is enhanced with ARIA roles to optimize organization and facilitate navigation
Page breaks included from the original print source
For readers with color vision deficiency, use of color (e.g., in diagrams, graphics and charts, in prompts, or on buttons inviting a response) is not the sole means of graphical distinction or of conveying information
The body text is presented with a contrast ratio of at least 4.5:1 (or 3:1 for large/heading text)
Text-to-speech has been optimized through provision of PLS lexicons, SSML or CSS Speech synthesis hints or other speech synthesis markup languages or hinting
Ultra-high contrast between text and background
E-publication includes basic navigation (usually less detailed than TOC-based navigation)
Where links, controls or buttons are included in the content, the purpose or functionality of each link, control or button is apparent from the associated text alone - or where it is unclear, separate link, control or button descriptions are provided
All (or substantially all) textual matter is arranged in a single logical reading order (including text that is visually presented as separate from the main text flow, e.g., in boxouts, captions, tables, footnotes, endnotes, citations, etc.). Non-textual content is also linked from within this logical reading order. (Purely decorative non-text content can be ignored).
Where interactive content is included in the product, controls are provided (e.g., for speed, pause and resume, reset) and labelled to make their use clear.
The language of the text has been specified (e.g., via the HTML or XML lang attribute) to optimise text-to-speech (and other alternative renderings), both at the whole document level and, where appropriate, for individual words, phrases or passages in a different language.
We use cookies that are necessary to make our site work. We may also use additional cookies to analyze, improve, and personalize our content and your digital experience. You can manage your cookie preferences using the “Cookie settings” link. For more information, see ourCookie Policy
Opt-Out Request Honored
Cookie Preference Center
We use cookies which are necessary to make our site work. We may also use additional cookies to analyse, improve and personalise our content and your digital experience. For more information, see our Cookie Policy and the list of Google Ad-Tech Vendors.
You may choose not to allow some types of cookies. However, blocking some types may impact your experience of our site and the services we are able to offer. See the different category headings below to find out more or change your settings.
You may also be able to exercise your privacy choices as described in our Privacy Policy
Manage Consent Preferences
Strictly Necessary Cookies
Always active
These cookies are necessary for the website to function and cannot be switched off in our systems. They are usually only set in response to actions made by you which amount to a request for services, such as setting your privacy preferences, logging in or filling in forms. You can set your browser to block or alert you about these cookies, but some parts of the site will not then work.
Functional Cookies
These cookies enable the website to provide enhanced functionality and personalisation. They may be set by us or by third party providers whose services we have added to our pages. If you do not allow these cookies then some or all of these services may not function properly.
Performance Cookies
These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They help us to know which pages are the most and least popular and see how visitors move around the site.
Targeting Cookies
These cookies may be set through our site by our advertising partners. They may be used by those companies to build a profile of your interests and show you relevant adverts on other sites. If you do not allow these cookies, you will experience less targeted advertising.