Thoroughly revised, updated, and extended by experts in their fields, and edited by Professors Kevin Taylor and Michael Aulton, Aulton's Pharmaceutics, 7th Edition, comprehensively covers the science and practice of formulation, pharmaceutical manufacturing, and drug delivery. This essential pharmaceutics textbook offers a complete course in one book for students in all years of undergraduate pharmacy and pharmaceutical sciences degrees. It is also an invaluable resource for students undertaking postgraduate studies in the pharmaceutical sciences, practitioners in the pharmaceutical and associated industries, and those working in hospital pharmacy technical services and medicines regulation. It features a clear, readily accessible writing style, extensive illustrations, and numerous tables, figures, and information boxes to assist with the understanding of this complex subject area.
Provides an essential companion to the entire pharmaceutics curriculum from day one until the end of the course—written specifically for those new to the design and manufacture of dosage forms
Contains updates throughout to reflect advances in formulation and drug delivery science, pharmaceutical manufacturing, quality control and medicines regulation
Demonstrates how an understanding of relevant pharmaceutical science and technology is essential for the design and manufacture of high quality, safe, and effective medicines
Reflects current practices and future applications of formulation and drug delivery science to small drug molecules, biotechnology products including antibodies and nucleic acids, and nanomedicines
Includes key points boxes for quick summaries of important information, and more than 400 multiple-choice questions online for self-assessment to review and consolidate learning
An eBook version is included with purchase. The eBook allows access to all of the text, figures, and references, with the ability to search, make notes and highlights, and have content read aloud
Part 1 Scientific principles of dosage form design 2. Dissolution and solubility 3. Properties of solutions 4. Surfaces and interfaces 5. Disperse systems 6. Rheology 7. Kinetics
Part 2 Particle science and powder technology 8. Solid-state properties 9. Particle size analysis 10. Particle size reduction and size separation 11. Mixing 12. Powder flow
Part 3 Pharmaceutical microbiology and sterilization 13. Fundamentals of microbiology 14. Pharmaceutical applications of microbiological techniques 15. Action of physical and chemical agents on microorganisms 16. Principles of sterilization 17. Sterilization in practice
Part 4 Biopharmaceutical principles of drug delivery 18. Introduction to biopharmaceutics 19. Gastrointestinal tract – physiology and drug absorption 20. Bioavailability – physicochemical, dosage form and formulation factors 21. Assessment of biopharmaceutical properties 22. Dosage regimens
Part 5 Dosage form design and manufacture 23. Pharmaceutical preformulation 24. Solutions 25. Clarification 26. Suspensions 27. Emulsions and creams 28. Ointments, pastes, gels, cutaneous patches and topical sprays 29. Powders, granules and granulation 30. Drying 31. Tablets and compaction 32. Modified-release oral drug delivery 33. Coating of tablets and multiparticulates 34. Continuous manufacturing of tablets 35. Hard capsules 36. Soft capsules 37. Dissolution testing of solid dosage forms 38. Parenteral drug delivery 39. Pulmonary drug delivery 40. Nasal drug delivery 41. Ocular drug delivery 42. Otic drug delivery 43. Topical and transdermal drug delivery 44. Rectal and vaginal drug delivery 45. Preparation and delivery of biopharmaceuticals 46. Pharmaceutical nanotechnology and nanomedicines 47. Radiopharmaceuticals 48. The formulation and manufacture of plant medicines 49. Design and administration of medicines for paediatric and geriatric patients
Part 6 Packaging, stability and pharmaceutical regulation 50. Packaging 51. Chemical stability in dosage forms 52. Microbial contamination, spoilage and preservation of medicines 53. Product stability and stability testing 54. Pharmaceutical quality: the application of pharmaceutics in medicines regulation Self-assessment questions
Kevin M.G. Taylor, BPharm PhD FRPharmS, Professor of Clinical Pharmaceutics, UCL School of Pharmacy, London, UK and Michael E. Aulton, BPharm, PhD, FAAPS, FSP, FRPharmS, Emeritus Professor, De Montfort University, Leicester, UK
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